ERCC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007584Biological processresponse to nutrient
GO_0090656Biological processt-circle formation
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0006281Biological processDNA repair
GO_0007283Biological processspermatogenesis
GO_0048568Biological processembryonic organ development
GO_0036297Biological processinterstrand cross-link repair
GO_0008283Biological processcell population proliferation
GO_0006949Biological processsyncytium formation
GO_0010165Biological processresponse to X-ray
GO_0009650Biological processUV protection
GO_0032205Biological processnegative regulation of telomere maintenance
GO_0008340Biological processdetermination of adult lifespan
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0006289Biological processnucleotide-excision repair
GO_0035902Biological processresponse to immobilization stress
GO_0070914Biological processUV-damage excision repair
GO_0035264Biological processmulticellular organism growth
GO_0090399Biological processreplicative senescence
GO_0000720Biological processpyrimidine dimer repair by nucleotide-excision repair
GO_0046686Biological processresponse to cadmium ion
GO_0035166Biological processpost-embryonic hemopoiesis
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0009744Biological processresponse to sucrose
GO_1905765Biological processnegative regulation of protection from non-homologous end joining at telomere
GO_0008584Biological processmale gonad development
GO_0045190Biological processisotype switching
GO_0061819Biological processtelomeric DNA-containing double minutes formation
GO_0006312Biological processmitotic recombination
GO_0006979Biological processresponse to oxidative stress
GO_0048477Biological processoogenesis
GO_1904431Biological processpositive regulation of t-circle formation
GO_0000110Cellular componentnucleotide-excision repair factor 1 complex
GO_0005654Cellular componentnucleoplasm
GO_0070522Cellular componentERCC4-ERCC1 complex
GO_0000109Cellular componentnucleotide-excision repair complex
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0003677Molecular functionDNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0001094Molecular functionTFIID-class transcription factor complex binding
GO_1990599Molecular function3' overhang single-stranded DNA endodeoxyribonuclease activity
GO_0000014Molecular functionsingle-stranded DNA endodeoxyribonuclease activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameERCC1
Protein nameERCC1 protein
ERCC excision repair 1, endonuclease non-catalytic subunit
Excision repair protein
DNA excision repair protein ERCC-1
Synonyms
DescriptionFUNCTION: [Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. .; FUNCTION: [Isoform 2]: Not functional in the nucleotide excision repair pathway. .; FUNCTION: [Isoform 3]: Not functional in the nucleotide excision repair pathway. .; FUNCTION: [Isoform 4]: Not functional in the nucleotide excision repair pathway. .

AccessionsENST00000589214.1
Q8WWH8
ENST00000592444.5
ENST00000710953.1
K7ER60
ENST00000587888.5
A0AA34QVL1
ENST00000590701.5
ENST00000592083.5
K7EK97
K7EJL2
Q16456
K7ER89
ENST00000592023.5
ENST00000591636.5
K7EP14
ENST00000340192.11 [P07992-2]
P07992
ENST00000589381.5
K7EMT9
ENST00000300853.8 [P07992-1]
ENST00000589165.5 [P07992-1]
K7EJW9
K7ES46
ENST00000423698.6 [P07992-4]
ENST00000013807.9 [P07992-3]