ELAVL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0016441Biological processpost-transcriptional gene silencing
GO_0061157Biological processmRNA destabilization
GO_0048255Biological processmRNA stabilization
GO_2000036Biological processregulation of stem cell population maintenance
GO_0060965Biological processnegative regulation of miRNA-mediated gene silencing
GO_0006606Biological processprotein import into nucleus
GO_0045727Biological processpositive regulation of translation
GO_0070935Biological process3'-UTR-mediated mRNA stabilization
GO_0032930Biological processpositive regulation of superoxide anion generation
GO_0098978Cellular componentglutamatergic synapse
GO_0016528Cellular componentsarcoplasm
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0098794Cellular componentpostsynapse
GO_0000932Cellular componentP-body
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0019901Molecular functionprotein kinase binding
GO_0003729Molecular functionmRNA binding
GO_0106222Molecular functionlncRNA binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameELAVL1
Protein nameELAV-like protein 1 (Hu-antigen R) (HuR)
ELAV like RNA binding protein 1
SynonymsHUR
DescriptionFUNCTION: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability . Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs . Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs . Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro . With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR . .

AccessionsM0QZR9
ENST00000596459.5 [Q15717-1]
ENST00000596154.5
M0R055
Q15717
ENST00000593807.1
ENST00000407627.7 [Q15717-1]