DHPS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006412Biological processtranslation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0008216Biological processspermidine metabolic process
GO_0008612Biological processpeptidyl-lysine modification to peptidyl-hypusine
GO_0046203Biological processspermidine catabolic process
GO_0042593Biological processglucose homeostasis
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0034038Molecular functiondeoxyhypusine synthase activity

IV. Literature review

[source]
Gene nameDHPS
Protein nameDeoxyhypusine synthase (DHS) (EC 2.5.1.46)
Deoxyhypusine synthase
Deoxyhypusine synthase (Migration-inducing gene 13)
SynonymsDS
DescriptionFUNCTION: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue . This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. .

AccessionsQ5J8M5
P49366
ENST00000594424.5 [P49366-3]
ENST00000598246.5
ENST00000595100.1
ENST00000597152.5
ENST00000600864.5
M0R253
ENST00000596162.1
ENST00000600451.5
ENST00000595912.5
ENST00000593423.5
M0R0V2
M0R1T4
B4E3M2
ENST00000601537.5
M0QX43
M0QZT3
M0R1T2
M0R264
ENST00000600639.1
ENST00000598850.5
ENST00000351660.9 [P49366-2]
ENST00000601639.5
M0QXT2
M0QYZ7
ENST00000210060.12 [P49366-1]
M0R0J4