DERL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0008284Biological processpositive regulation of cell population proliferation
GO_1904153Biological processnegative regulation of retrograde protein transport, ER to cytosol
GO_0030970Biological processretrograde protein transport, ER to cytosol
GO_0030307Biological processpositive regulation of cell growth
GO_0036503Biological processERAD pathway
GO_0001967Biological processsuckling behavior
GO_0005783Cellular componentendoplasmic reticulum
GO_0005770Cellular componentlate endosome
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005769Cellular componentearly endosome
GO_0044877Molecular functionprotein-containing complex binding
GO_0005047Molecular functionsignal recognition particle binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDERL2
Protein nameDerlin 2
Derlin
Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)
SynonymsCGI-101
SBBI53
FLANA
DER2
DescriptionFUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins . May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation . .; FUNCTION: (Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. .

FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. .

FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. .

FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. .

AccessionsI3L0R8
ENST00000573637.5
ENST00000571971.1
I3L1S8
ENST00000574952.5
ENST00000575605.5
ENST00000570848.5
ENST00000572834.5
ENST00000576551.5
ENST00000158771.9
ENST00000571476.5
I3L1W3
Q9GZP9
K7EQE8
I3L4W7
I3L1T3
I3L3R8