COA1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	18 studies	29% ± 12%	Explore
B cell	16 studies	22% ± 6%	Explore
fibroblast	14 studies	24% ± 10%	Explore
CD8-positive, alpha-beta T cell	13 studies	21% ± 6%	Explore
astrocyte	13 studies	30% ± 14%	Explore
CD4-positive, alpha-beta T cell	10 studies	20% ± 5%	Explore
oligodendrocyte precursor cell	10 studies	36% ± 15%	Explore
T cell	9 studies	22% ± 5%	Explore
microglial cell	9 studies	31% ± 11%	Explore
epithelial cell	9 studies	35% ± 15%	Explore
natural killer cell	9 studies	22% ± 5%	Explore
oligodendrocyte	9 studies	28% ± 9%	Explore
GABAergic neuron	8 studies	43% ± 22%	Explore
glutamatergic neuron	8 studies	44% ± 27%	Explore
macrophage	8 studies	33% ± 7%	Explore
adipocyte	8 studies	31% ± 9%	Explore
neuron	7 studies	34% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	25% ± 4%	Explore
connective tissue cell	6 studies	22% ± 5%	Explore
naive B cell	6 studies	18% ± 2%	Explore
interneuron	6 studies	42% ± 23%	Explore
myeloid cell	6 studies	20% ± 3%	Explore
retinal rod cell	6 studies	25% ± 4%	Explore
ciliated cell	6 studies	29% ± 8%	Explore
type I pneumocyte	6 studies	25% ± 5%	Explore
type II pneumocyte	6 studies	29% ± 8%	Explore
gamma-delta T cell	5 studies	28% ± 14%	Explore
amacrine cell	5 studies	30% ± 8%	Explore
retina horizontal cell	5 studies	25% ± 8%	Explore
retinal cone cell	5 studies	36% ± 17%	Explore
cardiac muscle cell	5 studies	35% ± 4%	Explore
mast cell	5 studies	24% ± 4%	Explore
T follicular helper cell	5 studies	19% ± 2%	Explore
endothelial cell of lymphatic vessel	5 studies	24% ± 5%	Explore
club cell	5 studies	27% ± 10%	Explore
pericyte	5 studies	24% ± 6%	Explore
basal cell	5 studies	36% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	25% ± 3%	Explore
granule cell	4 studies	23% ± 5%	Explore
myofibroblast cell	4 studies	23% ± 10%	Explore
plasma cell	4 studies	28% ± 12%	Explore
lymphocyte	4 studies	34% ± 10%	Explore
OFF-bipolar cell	4 studies	19% ± 2%	Explore
dendritic cell	4 studies	30% ± 11%	Explore
abnormal cell	4 studies	30% ± 15%	Explore
respiratory goblet cell	4 studies	32% ± 11%	Explore
smooth muscle cell	4 studies	23% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 2%	Explore
goblet cell	4 studies	29% ± 19%	Explore
hematopoietic precursor cell	3 studies	26% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	22% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	32% ± 10%	Explore
non-classical monocyte	3 studies	24% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	24% ± 3%	Explore
epithelial cell of proximal tubule	3 studies	21% ± 6%	Explore
neural crest cell	3 studies	23% ± 3%	Explore
GABAergic interneuron	3 studies	27% ± 5%	Explore
glial cell	3 studies	29% ± 9%	Explore
retinal ganglion cell	3 studies	40% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	18% ± 3%	Explore
retinal bipolar neuron	3 studies	28% ± 8%	Explore
Mueller cell	3 studies	19% ± 3%	Explore
GABAergic amacrine cell	3 studies	24% ± 6%	Explore
ON-bipolar cell	3 studies	20% ± 3%	Explore
glycinergic amacrine cell	3 studies	22% ± 3%	Explore
rod bipolar cell	3 studies	28% ± 1%	Explore
erythroblast	3 studies	33% ± 16%	Explore
hepatocyte	3 studies	38% ± 17%	Explore
muscle cell	3 studies	29% ± 16%	Explore
ependymal cell	3 studies	28% ± 13%	Explore
granulocyte monocyte progenitor cell	3 studies	21% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	31% ± 8%	Explore
leukocyte	3 studies	26% ± 5%	Explore
alveolar macrophage	3 studies	25% ± 8%	Explore
monocyte	3 studies	26% ± 1%	Explore
transit amplifying cell	3 studies	39% ± 24%	Explore
plasmacytoid dendritic cell	3 studies	21% ± 5%	Explore
mucus secreting cell	3 studies	23% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	35% ± 19%	Explore
lung	9 studies	22% ± 7%	Explore
eye	7 studies	28% ± 11%	Explore
heart	4 studies	24% ± 5%	Explore
liver	4 studies	36% ± 17%	Explore
peripheral blood	3 studies	24% ± 4%	Explore
intestine	3 studies	22% ± 9%	Explore
adipose	3 studies	34% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2031.49	459 / 459	100%	12.23	1118 / 1118
esophagus	100%	1525.44	1445 / 1445	100%	10.40	183 / 183
intestine	100%	1688.82	966 / 966	100%	9.70	527 / 527
lung	100%	1748.96	578 / 578	100%	12.82	1155 / 1155
ovary	100%	2581.26	180 / 180	100%	10.57	430 / 430
pancreas	100%	1560.46	328 / 328	100%	8.80	178 / 178
stomach	100%	1425.28	359 / 359	100%	9.31	286 / 286
uterus	100%	2157.01	170 / 170	100%	11.39	459 / 459
brain	100%	1758.00	2639 / 2642	100%	13.77	705 / 705
prostate	100%	2131.94	245 / 245	100%	8.61	501 / 502
kidney	100%	2046.85	89 / 89	100%	10.20	898 / 901
bladder	100%	1722.57	21 / 21	100%	10.73	502 / 504
skin	100%	2104.61	1809 / 1809	100%	11.94	470 / 472
thymus	100%	2117.22	653 / 653	100%	9.74	602 / 605
adrenal gland	100%	1725.66	258 / 258	98%	8.35	226 / 230
liver	100%	998.32	226 / 226	98%	5.47	396 / 406
adipose	100%	1703.36	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	12.88	29 / 29
muscle	100%	1854.91	803 / 803	0%	0	0 / 0
spleen	100%	2633.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	10.91	45 / 45
ureter	0%	0	0 / 0	100%	4.64	1 / 1
blood vessel	100%	1581.45	1333 / 1335	0%	0	0 / 0
heart	99%	1823.68	852 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	5.98	77 / 80
peripheral blood	92%	1417.59	851 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0033617	Biological process	mitochondrial cytochrome c oxidase assembly
GO_0032981	Biological process	mitochondrial respiratory chain complex I assembly
GO_0005829	Cellular component	cytosol
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	COA1
Protein name	Cytochrome c oxidase assembly factor 1 Cytochrome c oxidase assembly factor 1 homolog (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa)
Synonyms	MITRAC15 C7orf44
Description	FUNCTION: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV . As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I . .
Accessions	F2Z2J3 ENST00000446330.6 F8WBS2 ENST00000415076.6 Q9GZY4 ENST00000457939.1 ENST00000451651.5 ENST00000415798.5 ENST00000310564.10 ENST00000446564.5 C9JA07 ENST00000395879.5 ENST00000418140.5 C9J6J1 ENST00000223336.11 ENST00000438444.5 ENST00000431651.5

COA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review