CMPK1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	25% ± 11%	Explore
B cell	24 studies	29% ± 11%	Explore
natural killer cell	22 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	22 studies	29% ± 12%	Explore
CD8-positive, alpha-beta T cell	20 studies	27% ± 11%	Explore
T cell	19 studies	30% ± 11%	Explore
fibroblast	19 studies	27% ± 12%	Explore
regulatory T cell	17 studies	24% ± 8%	Explore
memory B cell	16 studies	27% ± 9%	Explore
smooth muscle cell	15 studies	21% ± 6%	Explore
macrophage	15 studies	21% ± 7%	Explore
mast cell	14 studies	25% ± 5%	Explore
naive B cell	14 studies	24% ± 6%	Explore
gamma-delta T cell	14 studies	27% ± 10%	Explore
pericyte	14 studies	24% ± 8%	Explore
basal cell	13 studies	34% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	31% ± 12%	Explore
mature NK T cell	12 studies	25% ± 6%	Explore
endothelial cell of lymphatic vessel	11 studies	22% ± 7%	Explore
epithelial cell	11 studies	44% ± 18%	Explore
ciliated cell	10 studies	42% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	30% ± 11%	Explore
endothelial cell of artery	10 studies	23% ± 5%	Explore
goblet cell	10 studies	37% ± 13%	Explore
platelet	9 studies	31% ± 10%	Explore
secretory cell	9 studies	33% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	23% ± 6%	Explore
capillary endothelial cell	9 studies	19% ± 3%	Explore
mucosal invariant T cell	9 studies	23% ± 5%	Explore
vein endothelial cell	9 studies	19% ± 3%	Explore
plasmacytoid dendritic cell	9 studies	27% ± 12%	Explore
conventional dendritic cell	8 studies	32% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	28% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	31% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 7%	Explore
endothelial cell of vascular tree	8 studies	24% ± 7%	Explore
plasma cell	7 studies	28% ± 11%	Explore
respiratory goblet cell	7 studies	32% ± 14%	Explore
classical monocyte	7 studies	25% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	26% ± 10%	Explore
T follicular helper cell	7 studies	35% ± 12%	Explore
connective tissue cell	7 studies	26% ± 11%	Explore
club cell	6 studies	32% ± 13%	Explore
non-classical monocyte	6 studies	28% ± 13%	Explore
abnormal cell	6 studies	27% ± 12%	Explore
CD4-positive helper T cell	5 studies	23% ± 8%	Explore
hematopoietic precursor cell	5 studies	27% ± 14%	Explore
mononuclear phagocyte	5 studies	27% ± 12%	Explore
epithelial cell of proximal tubule	5 studies	23% ± 4%	Explore
enterocyte	5 studies	30% ± 6%	Explore
myeloid cell	5 studies	26% ± 10%	Explore
brush cell	5 studies	27% ± 10%	Explore
alveolar macrophage	5 studies	21% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	32% ± 14%	Explore
innate lymphoid cell	5 studies	27% ± 8%	Explore
GABAergic neuron	5 studies	32% ± 13%	Explore
duct epithelial cell	4 studies	35% ± 7%	Explore
pancreatic A cell	4 studies	37% ± 14%	Explore
type B pancreatic cell	4 studies	44% ± 18%	Explore
leukocyte	4 studies	25% ± 5%	Explore
neuron	4 studies	27% ± 9%	Explore
intestinal crypt stem cell	4 studies	29% ± 9%	Explore
retinal ganglion cell	4 studies	57% ± 29%	Explore
megakaryocyte	4 studies	28% ± 14%	Explore
pro-B cell	4 studies	26% ± 7%	Explore
astrocyte	4 studies	23% ± 5%	Explore
microglial cell	4 studies	23% ± 6%	Explore
monocyte	4 studies	26% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 9%	Explore
hepatocyte	4 studies	48% ± 26%	Explore
glutamatergic neuron	4 studies	43% ± 15%	Explore
T-helper 17 cell	4 studies	37% ± 16%	Explore
oligodendrocyte	4 studies	19% ± 3%	Explore
type I pneumocyte	3 studies	27% ± 11%	Explore
plasmablast	3 studies	56% ± 6%	Explore
squamous epithelial cell	3 studies	37% ± 28%	Explore
glomerular endothelial cell	3 studies	20% ± 1%	Explore
kidney loop of Henle epithelial cell	3 studies	17% ± 2%	Explore
transit amplifying cell	3 studies	28% ± 4%	Explore
myofibroblast cell	3 studies	21% ± 4%	Explore
neuroendocrine cell	3 studies	32% ± 20%	Explore
immature B cell	3 studies	20% ± 2%	Explore
precursor B cell	3 studies	20% ± 2%	Explore
mucus secreting cell	3 studies	49% ± 17%	Explore
serous secreting cell	3 studies	53% ± 20%	Explore
adipocyte	3 studies	21% ± 3%	Explore
intraepithelial lymphocyte	3 studies	21% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	42% ± 10%	Explore
dendritic cell	3 studies	46% ± 23%	Explore
pancreatic ductal cell	3 studies	63% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 7%	Explore
interneuron	3 studies	33% ± 15%	Explore
erythrocyte	3 studies	29% ± 14%	Explore
progenitor cell of mammary luminal epithelium	3 studies	30% ± 10%	Explore
oligodendrocyte precursor cell	3 studies	21% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	29% ± 14%	Explore
peripheral blood	11 studies	32% ± 11%	Explore
intestine	10 studies	24% ± 10%	Explore
brain	7 studies	27% ± 10%	Explore
liver	6 studies	31% ± 19%	Explore
eye	5 studies	20% ± 6%	Explore
pancreas	4 studies	43% ± 16%	Explore
kidney	4 studies	20% ± 2%	Explore
lymph node	3 studies	28% ± 11%	Explore
breast	3 studies	26% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9044.95	1445 / 1445	100%	188.06	183 / 183
liver	100%	9580.06	226 / 226	100%	130.76	406 / 406
pancreas	100%	5406.43	328 / 328	100%	187.36	178 / 178
prostate	100%	8366.73	245 / 245	100%	284.67	502 / 502
breast	100%	9052.26	459 / 459	100%	147.90	1117 / 1118
lung	100%	7336.09	577 / 578	100%	155.45	1155 / 1155
brain	100%	5504.22	2635 / 2642	100%	98.41	705 / 705
bladder	100%	8384.00	21 / 21	100%	147.56	502 / 504
intestine	100%	8329.37	966 / 966	99%	209.57	524 / 527
thymus	100%	7924.34	653 / 653	99%	134.19	601 / 605
stomach	100%	6001.23	359 / 359	99%	205.19	283 / 286
uterus	100%	4736.81	170 / 170	99%	138.94	454 / 459
ovary	100%	4051.27	180 / 180	99%	70.37	425 / 430
kidney	100%	5758.97	89 / 89	97%	105.36	878 / 901
skin	100%	7363.55	1808 / 1809	94%	93.56	446 / 472
adrenal gland	100%	4536.00	257 / 258	88%	50.51	203 / 230
adipose	100%	10054.15	1204 / 1204	0%	0	0 / 0
blood vessel	100%	12090.84	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	100.88	29 / 29
muscle	100%	5743.43	803 / 803	0%	0	0 / 0
spleen	100%	4787.36	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	132.20	45 / 45
heart	97%	4467.28	834 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	76%	52.24	61 / 80
peripheral blood	59%	3556.95	545 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0046705	Biological process	CDP biosynthetic process
GO_0006222	Biological process	UMP biosynthetic process
GO_0006207	Biological process	'de novo' pyrimidine nucleobase biosynthetic process
GO_0046940	Biological process	nucleoside monophosphate phosphorylation
GO_0015949	Biological process	nucleobase-containing small molecule interconversion
GO_0006225	Biological process	UDP biosynthetic process
GO_0009220	Biological process	pyrimidine ribonucleotide biosynthetic process
GO_0005730	Cellular component	nucleolus
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0033862	Molecular function	UMP kinase activity
GO_0004550	Molecular function	nucleoside diphosphate kinase activity
GO_0036431	Molecular function	dCMP kinase activity
GO_0004849	Molecular function	uridine kinase activity
GO_0036430	Molecular function	CMP kinase activity
GO_0005524	Molecular function	ATP binding
GO_0004127	Molecular function	(d)CMP kinase activity
GO_0050145	Molecular function	nucleoside monophosphate kinase activity

IV. Literature review

[source]

Gene name	CMPK1
Protein name	Cytidine/uridine monophosphate kinase 1 UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) nucleoside-diphosphate kinase (EC 2.7.4.6)
Synonyms	CMPK CMK UMPK UMK UCK
Description	FUNCTION: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. . FUNCTION: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. .
Accessions	ENST00000471289.2 ENST00000371873.10 [P30085-3] A0A494BXC7 ENST00000450808.2 ENST00000699075.1 [P30085-1] ENST00000699074.1 E9PJD2 P30085 Q5T0D2 ENST00000371871.8 A0A8V8TMN5

CMPK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review