CDK13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009966Biological processregulation of signal transduction
GO_0030097Biological processhemopoiesis
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_2000737Biological processnegative regulation of stem cell differentiation
GO_0006468Biological processprotein phosphorylation
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0008024Cellular componentcyclin/CDK positive transcription elongation factor complex
GO_0005576Cellular componentextracellular region
GO_0019908Cellular componentnuclear cyclin-dependent protein kinase holoenzyme complex
GO_0016607Cellular componentnuclear speck
GO_0002945Cellular componentcyclin K-CDK13 complex
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004672Molecular functionprotein kinase activity
GO_0008353Molecular functionRNA polymerase II CTD heptapeptide repeat kinase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameCDK13
Protein nameCyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)
Cyclin dependent kinase 13
SynonymsCDC2L
KIAA1791
CHED
CDC2L5
DescriptionFUNCTION: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. .

AccessionsENST00000643868.1
A0A2R8YFE7
ENST00000646039.1
ENST00000643859.1
A0A2R8YCQ1
A0A2R8YF61
ENST00000646437.1
ENST00000340829.10 [Q14004-2]
ENST00000643915.1
A0A2R8YEB7
A0A2R8Y644
ENST00000181839.10 [Q14004-1]
A0A2R8Y7W5
A0A2R8Y7Y0
A0A2R8Y4Z0
ENST00000645470.1
ENST00000642592.1
ENST00000642626.1
ENST00000484589.2
A0A2R8YD28
Q14004