BCL10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042327Biological processpositive regulation of phosphorylation
GO_0002906Biological processnegative regulation of mature B cell apoptotic process
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0050870Biological processpositive regulation of T cell activation
GO_0051260Biological processprotein homooligomerization
GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_0061760Biological processantifungal innate immune response
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0071260Biological processcellular response to mechanical stimulus
GO_0012501Biological processprogrammed cell death
GO_0001783Biological processB cell apoptotic process
GO_0045087Biological processinnate immune response
GO_0006968Biological processcellular defense response
GO_0050852Biological processT cell receptor signaling pathway
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0070231Biological processT cell apoptotic process
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0002250Biological processadaptive immune response
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0032765Biological processpositive regulation of mast cell cytokine production
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0001843Biological processneural tube closure
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0032094Biological processresponse to food
GO_0032761Biological processpositive regulation of lymphotoxin A production
GO_0043065Biological processpositive regulation of apoptotic process
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0001772Cellular componentimmunological synapse
GO_0002096Cellular componentpolkadots
GO_0045121Cellular componentmembrane raft
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005764Cellular componentlysosome
GO_0032449Cellular componentCBM complex
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005881Cellular componentcytoplasmic microtubule
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0050700Molecular functionCARD domain binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0002020Molecular functionprotease binding
GO_0019209Molecular functionkinase activator activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0140296Molecular functiongeneral transcription initiation factor binding
GO_0043422Molecular functionprotein kinase B binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameBCL10
Protein nameBCL10 immune signaling adaptor
Mutant B-cell CLL/lymphoma 10
B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10)
SynonymsCLAP
CIPER
DescriptionFUNCTION: Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation . Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines . Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex . This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines . Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity . Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) . Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK . .

AccessionsO95999
A2TDT2
ENST00000648566.1
ENST00000649060.1
A0A3B3ISX2
A0A087WWW9
ENST00000620248.3