ATP8A1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	17 studies	70% ± 21%	Explore
astrocyte	15 studies	37% ± 17%	Explore
endothelial cell	14 studies	32% ± 16%	Explore
glutamatergic neuron	13 studies	60% ± 27%	Explore
CD8-positive, alpha-beta T cell	13 studies	24% ± 9%	Explore
natural killer cell	12 studies	27% ± 12%	Explore
oligodendrocyte precursor cell	12 studies	37% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	21% ± 7%	Explore
GABAergic neuron	10 studies	57% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	22% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	27% ± 9%	Explore
T cell	8 studies	27% ± 9%	Explore
type II pneumocyte	7 studies	52% ± 19%	Explore
gamma-delta T cell	7 studies	23% ± 4%	Explore
neuron	6 studies	46% ± 14%	Explore
interneuron	6 studies	64% ± 19%	Explore
mature NK T cell	6 studies	19% ± 5%	Explore
type I pneumocyte	6 studies	42% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	29% ± 11%	Explore
epithelial cell	5 studies	22% ± 4%	Explore
retinal cone cell	5 studies	51% ± 25%	Explore
retina horizontal cell	5 studies	35% ± 20%	Explore
club cell	5 studies	34% ± 11%	Explore
granule cell	4 studies	46% ± 20%	Explore
macrophage	4 studies	24% ± 9%	Explore
microglial cell	4 studies	34% ± 9%	Explore
precursor B cell	4 studies	29% ± 7%	Explore
retinal pigment epithelial cell	4 studies	25% ± 6%	Explore
B cell	4 studies	30% ± 12%	Explore
cardiac muscle cell	4 studies	28% ± 1%	Explore
retinal rod cell	4 studies	38% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	22% ± 5%	Explore
GABAergic interneuron	3 studies	59% ± 2%	Explore
glial cell	3 studies	32% ± 15%	Explore
naive B cell	3 studies	18% ± 2%	Explore
plasma cell	3 studies	23% ± 4%	Explore
CD4-positive, alpha-beta T cell	3 studies	29% ± 2%	Explore
mucosal invariant T cell	3 studies	25% ± 7%	Explore
GABAergic amacrine cell	3 studies	28% ± 9%	Explore
glycinergic amacrine cell	3 studies	38% ± 14%	Explore
enteroendocrine cell	3 studies	25% ± 6%	Explore
lymphocyte	3 studies	50% ± 20%	Explore
goblet cell	3 studies	38% ± 29%	Explore
plasmacytoid dendritic cell	3 studies	18% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	28% ± 13%	Explore
regulatory T cell	3 studies	20% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	59% ± 18%	Explore
eye	5 studies	27% ± 9%	Explore
lung	5 studies	28% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	15748.14	653 / 653	95%	42.46	577 / 605
brain	100%	8702.52	2631 / 2642	92%	28.97	651 / 705
prostate	87%	2523.35	213 / 245	99%	34.64	498 / 502
adrenal gland	97%	3407.56	251 / 258	87%	17.96	201 / 230
intestine	93%	3444.86	894 / 966	73%	9.16	387 / 527
stomach	93%	2853.81	335 / 359	70%	7.67	199 / 286
lung	98%	4080.64	565 / 578	64%	10.38	739 / 1155
pancreas	91%	2009.50	299 / 328	65%	7.76	116 / 178
breast	82%	1759.69	377 / 459	48%	4.37	532 / 1118
kidney	35%	578.89	31 / 89	82%	11.22	740 / 901
ovary	99%	5551.69	179 / 180	13%	0.75	55 / 430
bladder	67%	1125.05	14 / 21	34%	3.70	170 / 504
spleen	100%	3281.45	241 / 241	0%	0	0 / 0
muscle	97%	4061.72	782 / 803	0%	0	0 / 0
uterus	67%	1006.71	114 / 170	28%	2.01	127 / 459
lymph node	0%	0	0 / 0	90%	14.81	26 / 29
esophagus	40%	678.72	585 / 1445	48%	6.77	87 / 183
adipose	84%	1913.58	1006 / 1204	0%	0	0 / 0
heart	83%	1949.28	713 / 861	0%	0	0 / 0
skin	27%	378.38	485 / 1809	39%	5.37	184 / 472
peripheral blood	54%	3324.08	506 / 929	0%	0	0 / 0
blood vessel	45%	733.38	604 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	38%	3.25	30 / 80
tonsil	0%	0	0 / 0	29%	1.71	13 / 45
liver	0%	0	0 / 226	3%	0.38	14 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0140331	Biological process	aminophospholipid translocation
GO_0007612	Biological process	learning
GO_0150104	Biological process	transport across blood-brain barrier
GO_0061092	Biological process	positive regulation of phospholipid translocation
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0030335	Biological process	positive regulation of cell migration
GO_0098655	Biological process	monoatomic cation transmembrane transport
GO_0045332	Biological process	phospholipid translocation
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0035577	Cellular component	azurophil granule membrane
GO_0070062	Cellular component	extracellular exosome
GO_0042584	Cellular component	chromaffin granule membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005802	Cellular component	trans-Golgi network
GO_1990531	Cellular component	phospholipid-translocating ATPase complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0031090	Cellular component	organelle membrane
GO_0090556	Molecular function	phosphatidylserine floppase activity
GO_0019829	Molecular function	ATPase-coupled monoatomic cation transmembrane transporter activity
GO_0140326	Molecular function	ATPase-coupled intramembrane lipid transporter activity
GO_0000287	Molecular function	magnesium ion binding
GO_0005524	Molecular function	ATP binding
GO_0140346	Molecular function	phosphatidylserine flippase activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ATP8A1
Protein name	ATP8A1 protein (ATPase phospholipid transporting 8A1) Phospholipid-transporting ATPase IA (EC 7.6.2.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1) ATPase phospholipid transporting 8A1
Synonyms	ATPIA
Description	FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids . Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) . The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity). .
Accessions	Q9Y2Q0 ENST00000700470.1 [Q9Y2Q0-2] ENST00000510289.1 ENST00000514372.5 H0Y8I6 ENST00000264449.14 [Q9Y2Q0-3] H0YAA1 H0YAJ4 ENST00000504024.1 Q4G1C1 ENST00000506602.5 ENST00000381668.9 [Q9Y2Q0-1]

ATP8A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review