ADK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	29 studies	31% ± 15%	Explore
naive B cell	19 studies	30% ± 10%	Explore
astrocyte	18 studies	41% ± 17%	Explore
endothelial cell	18 studies	40% ± 13%	Explore
microglial cell	15 studies	48% ± 14%	Explore
macrophage	14 studies	35% ± 15%	Explore
regulatory T cell	14 studies	22% ± 7%	Explore
glutamatergic neuron	13 studies	55% ± 25%	Explore
oligodendrocyte precursor cell	13 studies	36% ± 12%	Explore
memory B cell	13 studies	26% ± 7%	Explore
epithelial cell	12 studies	37% ± 20%	Explore
basal cell	12 studies	41% ± 26%	Explore
oligodendrocyte	12 studies	34% ± 14%	Explore
type II pneumocyte	11 studies	49% ± 28%	Explore
GABAergic neuron	11 studies	57% ± 24%	Explore
pericyte	11 studies	32% ± 14%	Explore
fibroblast	11 studies	35% ± 10%	Explore
type I pneumocyte	10 studies	56% ± 23%	Explore
smooth muscle cell	10 studies	33% ± 15%	Explore
adipocyte	10 studies	50% ± 11%	Explore
ciliated cell	9 studies	40% ± 21%	Explore
dendritic cell	8 studies	36% ± 7%	Explore
mast cell	8 studies	30% ± 13%	Explore
non-classical monocyte	7 studies	26% ± 10%	Explore
neuron	7 studies	42% ± 21%	Explore
club cell	7 studies	52% ± 22%	Explore
T cell	7 studies	35% ± 16%	Explore
plasmacytoid dendritic cell	7 studies	23% ± 8%	Explore
CD4-positive, alpha-beta T cell	6 studies	25% ± 6%	Explore
interneuron	6 studies	60% ± 25%	Explore
retinal ganglion cell	6 studies	55% ± 26%	Explore
retinal cone cell	6 studies	51% ± 25%	Explore
myeloid cell	6 studies	40% ± 14%	Explore
endothelial cell of lymphatic vessel	6 studies	34% ± 14%	Explore
natural killer cell	6 studies	23% ± 5%	Explore
hepatocyte	5 studies	65% ± 30%	Explore
plasma cell	5 studies	33% ± 6%	Explore
cardiac muscle cell	5 studies	52% ± 13%	Explore
monocyte	5 studies	52% ± 14%	Explore
cholangiocyte	4 studies	56% ± 23%	Explore
classical monocyte	4 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	16% ± 1%	Explore
granule cell	4 studies	38% ± 8%	Explore
progenitor cell	4 studies	36% ± 9%	Explore
CD8-positive, alpha-beta T cell	4 studies	22% ± 3%	Explore
mesothelial cell	4 studies	29% ± 11%	Explore
lymphocyte	4 studies	32% ± 12%	Explore
Mueller cell	4 studies	30% ± 9%	Explore
amacrine cell	4 studies	28% ± 7%	Explore
retina horizontal cell	4 studies	33% ± 11%	Explore
retinal rod cell	4 studies	46% ± 7%	Explore
leukocyte	4 studies	41% ± 16%	Explore
respiratory goblet cell	4 studies	47% ± 20%	Explore
conventional dendritic cell	3 studies	32% ± 4%	Explore
hematopoietic precursor cell	3 studies	33% ± 18%	Explore
GABAergic interneuron	3 studies	59% ± 5%	Explore
glial cell	3 studies	40% ± 13%	Explore
placental villous trophoblast	3 studies	40% ± 22%	Explore
mononuclear phagocyte	3 studies	30% ± 11%	Explore
mucosal invariant T cell	3 studies	26% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	28% ± 9%	Explore
GABAergic amacrine cell	3 studies	40% ± 14%	Explore
OFF-bipolar cell	3 studies	41% ± 11%	Explore
ON-bipolar cell	3 studies	46% ± 10%	Explore
glycinergic amacrine cell	3 studies	37% ± 7%	Explore
intermediate monocyte	3 studies	21% ± 5%	Explore
endothelial cell of vascular tree	3 studies	25% ± 8%	Explore
retinal pigment epithelial cell	3 studies	34% ± 24%	Explore
muscle cell	3 studies	27% ± 7%	Explore
neural progenitor cell	3 studies	39% ± 15%	Explore
connective tissue cell	3 studies	36% ± 9%	Explore
ependymal cell	3 studies	56% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	36% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	33% ± 12%	Explore
alveolar macrophage	3 studies	42% ± 8%	Explore
Schwann cell	3 studies	41% ± 19%	Explore
transit amplifying cell	3 studies	49% ± 33%	Explore
kidney loop of Henle epithelial cell	3 studies	37% ± 15%	Explore
renal principal cell	3 studies	46% ± 19%	Explore
abnormal cell	3 studies	39% ± 23%	Explore
mucus secreting cell	3 studies	37% ± 6%	Explore
myoepithelial cell	3 studies	43% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	17% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	46% ± 21%	Explore
lung	7 studies	40% ± 17%	Explore
liver	5 studies	40% ± 19%	Explore
eye	5 studies	44% ± 11%	Explore
peripheral blood	4 studies	20% ± 4%	Explore
heart	4 studies	37% ± 8%	Explore
placenta	3 studies	27% ± 6%	Explore
adipose	3 studies	49% ± 20%	Explore
kidney	3 studies	40% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	1331.90	653 / 653	100%	48.46	604 / 605
lung	100%	1392.30	576 / 578	100%	36.18	1155 / 1155
breast	100%	1154.93	459 / 459	100%	27.89	1113 / 1118
liver	100%	3076.82	226 / 226	100%	27.19	404 / 406
bladder	100%	834.67	21 / 21	99%	29.55	501 / 504
esophagus	100%	1455.39	1444 / 1445	99%	32.38	182 / 183
uterus	100%	616.66	170 / 170	99%	32.54	456 / 459
brain	99%	934.78	2622 / 2642	100%	24.49	705 / 705
stomach	100%	601.96	358 / 359	99%	22.78	284 / 286
prostate	100%	796.58	245 / 245	99%	19.45	497 / 502
intestine	100%	794.99	962 / 966	99%	24.69	522 / 527
ovary	99%	463.02	178 / 180	100%	16.19	428 / 430
pancreas	99%	582.11	325 / 328	99%	16.43	176 / 178
adrenal gland	100%	966.67	258 / 258	97%	17.02	223 / 230
kidney	100%	1131.58	89 / 89	96%	12.83	864 / 901
skin	100%	2281.81	1809 / 1809	92%	13.17	435 / 472
adipose	100%	1202.11	1204 / 1204	0%	0	0 / 0
spleen	100%	812.65	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	34.93	45 / 45
ureter	0%	0	0 / 0	100%	26.97	1 / 1
blood vessel	100%	920.68	1331 / 1335	0%	0	0 / 0
muscle	100%	881.73	800 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	20.42	28 / 29
heart	94%	966.59	806 / 861	0%	0	0 / 0
peripheral blood	79%	943.63	738 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	74%	8.65	59 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006166	Biological process	purine ribonucleoside salvage
GO_0044209	Biological process	AMP salvage
GO_0006144	Biological process	purine nucleobase metabolic process
GO_0032263	Biological process	GMP salvage
GO_0009156	Biological process	ribonucleoside monophosphate biosynthetic process
GO_0006175	Biological process	dATP biosynthetic process
GO_0106383	Biological process	dAMP salvage
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005634	Cellular component	nucleus
GO_0004001	Molecular function	adenosine kinase activity
GO_0004136	Molecular function	deoxyadenosine kinase activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	ADK
Protein name	Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase)
Synonyms
Description	FUNCTION: Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. . FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. . FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. . FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. . FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. . FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. . FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. . FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. . FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. .
Accessions	A0A5F9ZH31 ENST00000478611.2 A0A5K1VW94 A0A5F9ZH76 ENST00000539909.6 [P55263-1] ENST00000672920.1 ENST00000372734.5 [P55263-2] A0A5F9ZGZ8 ENST00000672394.1 A0A5F9ZHJ1 ENST00000673310.1 A0A5F9ZH83 ENST00000673027.1 [P55263-4] ENST00000286621.7 ENST00000672604.1 A0A5K1VW54 ENST00000541550.6 ENST00000672429.1 [P55263-3] ENST00000673352.1 P55263 A0A5F9ZH72

ADK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review