WDR43 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000234Biological processpositive regulation of rRNA processing
GO_0034243Biological processregulation of transcription elongation by RNA polymerase II
GO_2000036Biological processregulation of stem cell population maintenance
GO_0000462Biological processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005730Cellular componentnucleolus
GO_0001650Cellular componentfibrillar center
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0032040Cellular componentsmall-subunit processome
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0005515Molecular functionprotein binding
GO_0003711Molecular functiontranscription elongation factor activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameWDR43
Protein nameWD repeat domain 43
WDR43 protein
WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)
SynonymsKIAA0007
UTP5
DescriptionFUNCTION: Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I . Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). .

AccessionsC9JH61
ENST00000434238.1
Q15061
ENST00000440983.1
C9IZK7
ENST00000296126.6
C9JEE7
ENST00000407426.8
Q8TB67