VPS26A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0006886Biological processintracellular protein transport
GO_0016241Biological processregulation of macroautophagy
GO_0032456Biological processendocytic recycling
GO_0030904Cellular componentretromer complex
GO_0097422Cellular componenttubular endosome
GO_0010008Cellular componentendosome membrane
GO_0005764Cellular componentlysosome
GO_0005768Cellular componentendosome
GO_0005829Cellular componentcytosol
GO_0031982Cellular componentvesicle
GO_0030906Cellular componentretromer, cargo-selective complex
GO_0005769Cellular componentearly endosome
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS26A
Protein nameVacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26)
VPS26 retromer complex component A
SynonymsVPS26
DescriptionFUNCTION: Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R . Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) . Required for the endosomal localization of WASHC2A (indicative for the WASH complex) . Required for the endosomal localization of TBC1D5 . Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP . Involved in retromer-independent lysosomal sorting of F2R . Involved in recycling of ADRB2 . Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). .

AccessionsENST00000489656.5
O75436
ENST00000395098.5 [O75436-2]
S4R3Q6
ENST00000373382.5 [O75436-1]
ENST00000489794.1
ENST00000263559.11 [O75436-1]
S4R2Y3