UGCG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006679Biological processglucosylceramide biosynthetic process
GO_0009966Biological processregulation of signal transduction
GO_0030216Biological processkeratinocyte differentiation
GO_0008544Biological processepidermis development
GO_0033210Biological processleptin-mediated signaling pathway
GO_1903575Biological processcornified envelope assembly
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0030154Biological processcell differentiation
GO_0048666Biological processneuron development
GO_0098856Biological processintestinal lipid absorption
GO_0061436Biological processestablishment of skin barrier
GO_0006497Biological processprotein lipidation
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0102769Molecular functiondihydroceramide glucosyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0008120Molecular functionceramide glucosyltransferase activity

IV. Literature review

[source]
Gene nameUGCG
Protein nameCeramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase)
Synonyms
DescriptionFUNCTION: Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi . Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) . GlcCer is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures . Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction, implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (By similarity). They are required for instance in the proper development and functioning of the nervous system (By similarity). As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (By similarity). They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (By similarity). The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor . .

AccessionsQ16739
ENST00000374279.4