Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 30 studies | 31% ± 16% | |
plasmacytoid dendritic cell | 27 studies | 79% ± 14% | |
fibroblast | 22 studies | 27% ± 13% | |
ciliated cell | 17 studies | 31% ± 15% | |
macrophage | 15 studies | 24% ± 9% | |
smooth muscle cell | 14 studies | 22% ± 5% | |
pericyte | 13 studies | 32% ± 16% | |
basal cell | 12 studies | 29% ± 13% | |
B cell | 11 studies | 20% ± 3% | |
endothelial cell of vascular tree | 11 studies | 32% ± 12% | |
epithelial cell | 10 studies | 42% ± 22% | |
vein endothelial cell | 10 studies | 35% ± 11% | |
dendritic cell | 9 studies | 33% ± 14% | |
secretory cell | 9 studies | 35% ± 16% | |
respiratory goblet cell | 8 studies | 34% ± 16% | |
microglial cell | 8 studies | 31% ± 12% | |
myeloid cell | 8 studies | 29% ± 10% | |
club cell | 7 studies | 34% ± 14% | |
endothelial cell of artery | 6 studies | 22% ± 6% | |
capillary endothelial cell | 5 studies | 26% ± 8% | |
regulatory T cell | 5 studies | 18% ± 2% | |
GABAergic neuron | 5 studies | 36% ± 17% | |
connective tissue cell | 5 studies | 24% ± 7% | |
interneuron | 5 studies | 30% ± 18% | |
endothelial cell of lymphatic vessel | 4 studies | 23% ± 4% | |
squamous epithelial cell | 4 studies | 40% ± 22% | |
conventional dendritic cell | 4 studies | 30% ± 10% | |
neuron | 4 studies | 24% ± 4% | |
retinal cone cell | 4 studies | 35% ± 10% | |
lymphocyte | 4 studies | 21% ± 5% | |
abnormal cell | 4 studies | 25% ± 11% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 30% ± 11% | |
type I pneumocyte | 4 studies | 22% ± 4% | |
glutamatergic neuron | 4 studies | 49% ± 17% | |
goblet cell | 4 studies | 31% ± 19% | |
naive B cell | 4 studies | 18% ± 2% | |
epithelial cell of proximal tubule | 3 studies | 23% ± 10% | |
memory B cell | 3 studies | 18% ± 4% | |
kidney loop of Henle epithelial cell | 3 studies | 18% ± 1% | |
plasma cell | 3 studies | 34% ± 11% | |
luminal cell of prostate epithelium | 3 studies | 23% ± 5% | |
type II pneumocyte | 3 studies | 17% ± 2% | |
pancreatic ductal cell | 3 studies | 45% ± 9% | |
enterocyte | 3 studies | 20% ± 3% | |
astrocyte | 3 studies | 22% ± 1% | |
oligodendrocyte precursor cell | 3 studies | 23% ± 0% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4590.95 | 1444 / 1445 | 100% | 54.40 | 183 / 183 |
lung | 100% | 6600.05 | 577 / 578 | 100% | 59.18 | 1153 / 1155 |
kidney | 100% | 5461.56 | 89 / 89 | 99% | 89.85 | 894 / 901 |
breast | 100% | 4746.98 | 459 / 459 | 99% | 136.69 | 1105 / 1118 |
uterus | 100% | 2997.08 | 170 / 170 | 98% | 62.61 | 452 / 459 |
bladder | 100% | 3731.33 | 21 / 21 | 98% | 43.76 | 493 / 504 |
prostate | 99% | 2885.00 | 243 / 245 | 99% | 36.31 | 495 / 502 |
skin | 100% | 6988.62 | 1807 / 1809 | 98% | 94.41 | 461 / 472 |
intestine | 100% | 3741.97 | 965 / 966 | 96% | 34.66 | 506 / 527 |
stomach | 100% | 4439.29 | 359 / 359 | 96% | 34.02 | 274 / 286 |
adrenal gland | 100% | 7316.40 | 258 / 258 | 95% | 72.73 | 218 / 230 |
ovary | 100% | 2069.10 | 180 / 180 | 91% | 26.93 | 393 / 430 |
pancreas | 91% | 1669.89 | 297 / 328 | 99% | 57.56 | 176 / 178 |
thymus | 93% | 2128.70 | 609 / 653 | 90% | 24.57 | 545 / 605 |
liver | 89% | 1811.64 | 202 / 226 | 83% | 27.95 | 337 / 406 |
brain | 76% | 1356.89 | 2020 / 2642 | 88% | 27.76 | 622 / 705 |
lymph node | 0% | 0 | 0 / 0 | 100% | 54.63 | 29 / 29 |
spleen | 100% | 6165.54 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 58.40 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 24.02 | 1 / 1 |
adipose | 100% | 5913.84 | 1201 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 97% | 2334.58 | 1296 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 4759.06 | 855 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 88% | 46.08 | 70 / 80 |
heart | 72% | 1614.00 | 623 / 861 | 0% | 0 | 0 / 0 |
muscle | 47% | 794.31 | 374 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006679 | Biological process | glucosylceramide biosynthetic process |
GO_0009966 | Biological process | regulation of signal transduction |
GO_0030216 | Biological process | keratinocyte differentiation |
GO_0008544 | Biological process | epidermis development |
GO_0033210 | Biological process | leptin-mediated signaling pathway |
GO_1903575 | Biological process | cornified envelope assembly |
GO_0006688 | Biological process | glycosphingolipid biosynthetic process |
GO_0030154 | Biological process | cell differentiation |
GO_0048666 | Biological process | neuron development |
GO_0098856 | Biological process | intestinal lipid absorption |
GO_0061436 | Biological process | establishment of skin barrier |
GO_0006497 | Biological process | protein lipidation |
GO_0000139 | Cellular component | Golgi membrane |
GO_0016020 | Cellular component | membrane |
GO_0102769 | Molecular function | dihydroceramide glucosyltransferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0008120 | Molecular function | ceramide glucosyltransferase activity |
Gene name | UGCG |
Protein name | Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) |
Synonyms | |
Description | FUNCTION: Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi . Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) . GlcCer is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures . Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction, implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (By similarity). They are required for instance in the proper development and functioning of the nervous system (By similarity). As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (By similarity). They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (By similarity). The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor . . |
Accessions | Q16739 ENST00000374279.4 |