TRIM24 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0055074Biological processcalcium ion homeostasis
GO_0006366Biological processtranscription by RNA polymerase II
GO_0016567Biological processprotein ubiquitination
GO_0043434Biological processresponse to peptide hormone
GO_0010628Biological processpositive regulation of gene expression
GO_0071391Biological processcellular response to estrogen stimulus
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0070562Biological processregulation of vitamin D receptor signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0030163Biological processprotein catabolic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0031647Biological processregulation of protein stability
GO_0005726Cellular componentperichromatin fibrils
GO_0005739Cellular componentmitochondrion
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0001673Cellular componentmale germ cell nucleus
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0016922Molecular functionnuclear receptor binding
GO_0003682Molecular functionchromatin binding
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0034056Molecular functionestrogen response element binding
GO_0005102Molecular functionsignaling receptor binding
GO_0004672Molecular functionprotein kinase activity
GO_0008270Molecular functionzinc ion binding
GO_0002039Molecular functionp53 binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM24
Protein nameTranscription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
SynonymsRNF82
TIF1A
TIF1
DescriptionFUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation . Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway . Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 . .

AccessionsENST00000415680.6 [O15164-2]
O15164
ENST00000343526.9 [O15164-1]