TEAD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048568Biological processembryonic organ development
GO_0030307Biological processpositive regulation of cell growth
GO_0035329Biological processhippo signaling
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0065003Biological processprotein-containing complex assembly
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0140552Cellular componentTEAD-YAP complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTEAD1
Protein nameTEA domain transcription factor 1
Transcriptional enhancer factor TEF-1
Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13)
SynonymsTCF13
TEF1
DescriptionFUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. .

AccessionsENST00000527636
H0YE88
P28347
H0YEJ9
ENST00000527376.3
ENST00000527636.7 [P28347-1]
ENST00000526600.1
ENST00000527575.6
ENST00000334310.10 [P28347-2]
H0YCZ6
E9PKB7