Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 25 studies | 42% ± 19% | |
astrocyte | 19 studies | 54% ± 20% | |
pericyte | 18 studies | 33% ± 17% | |
fibroblast | 16 studies | 37% ± 17% | |
ciliated cell | 14 studies | 35% ± 16% | |
smooth muscle cell | 11 studies | 33% ± 12% | |
adipocyte | 11 studies | 60% ± 22% | |
oligodendrocyte | 11 studies | 27% ± 10% | |
oligodendrocyte precursor cell | 10 studies | 41% ± 13% | |
type I pneumocyte | 9 studies | 48% ± 21% | |
GABAergic neuron | 9 studies | 42% ± 19% | |
glutamatergic neuron | 9 studies | 40% ± 23% | |
epithelial cell | 9 studies | 44% ± 20% | |
neuron | 7 studies | 37% ± 21% | |
mesothelial cell | 7 studies | 38% ± 15% | |
basal cell | 7 studies | 35% ± 20% | |
endothelial cell of lymphatic vessel | 7 studies | 40% ± 13% | |
interneuron | 6 studies | 44% ± 10% | |
endothelial cell of artery | 6 studies | 32% ± 16% | |
connective tissue cell | 6 studies | 28% ± 15% | |
cardiac muscle cell | 5 studies | 51% ± 13% | |
club cell | 5 studies | 36% ± 12% | |
myofibroblast cell | 5 studies | 34% ± 18% | |
type II pneumocyte | 5 studies | 41% ± 8% | |
squamous epithelial cell | 4 studies | 45% ± 18% | |
cholangiocyte | 4 studies | 62% ± 18% | |
hepatocyte | 4 studies | 67% ± 26% | |
abnormal cell | 4 studies | 32% ± 17% | |
granule cell | 4 studies | 27% ± 7% | |
vein endothelial cell | 4 studies | 38% ± 24% | |
Mueller cell | 4 studies | 47% ± 16% | |
endothelial cell of vascular tree | 4 studies | 36% ± 22% | |
hepatic stellate cell | 3 studies | 48% ± 21% | |
GABAergic interneuron | 3 studies | 28% ± 4% | |
glial cell | 3 studies | 44% ± 15% | |
progenitor cell | 3 studies | 39% ± 15% | |
GABAergic amacrine cell | 3 studies | 23% ± 4% | |
retinal rod cell | 3 studies | 40% ± 13% | |
retinal pigment epithelial cell | 3 studies | 46% ± 22% | |
ependymal cell | 3 studies | 70% ± 12% | |
enteroendocrine cell | 3 studies | 29% ± 9% | |
capillary endothelial cell | 3 studies | 30% ± 10% | |
respiratory goblet cell | 3 studies | 40% ± 15% | |
goblet cell | 3 studies | 36% ± 19% | |
transit amplifying cell | 3 studies | 39% ± 28% | |
podocyte | 3 studies | 59% ± 15% | |
mucus secreting cell | 3 studies | 30% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 7398.98 | 1443 / 1445 | 99% | 31.49 | 182 / 183 |
skin | 100% | 9194.13 | 1802 / 1809 | 99% | 45.34 | 465 / 472 |
ovary | 100% | 7238.15 | 180 / 180 | 98% | 27.55 | 421 / 430 |
lung | 99% | 5816.15 | 573 / 578 | 98% | 25.24 | 1137 / 1155 |
kidney | 100% | 3603.42 | 89 / 89 | 97% | 27.33 | 876 / 901 |
breast | 100% | 7378.38 | 457 / 459 | 97% | 25.02 | 1083 / 1118 |
uterus | 100% | 8031.64 | 170 / 170 | 96% | 24.41 | 442 / 459 |
thymus | 100% | 4855.26 | 651 / 653 | 95% | 36.31 | 575 / 605 |
intestine | 99% | 9881.60 | 960 / 966 | 94% | 18.83 | 498 / 527 |
bladder | 100% | 12794.48 | 21 / 21 | 94% | 19.02 | 473 / 504 |
prostate | 99% | 5125.01 | 242 / 245 | 93% | 17.14 | 468 / 502 |
stomach | 94% | 5650.02 | 336 / 359 | 94% | 21.93 | 270 / 286 |
adrenal gland | 92% | 2615.48 | 237 / 258 | 91% | 26.08 | 209 / 230 |
brain | 75% | 1793.67 | 1970 / 2642 | 100% | 40.11 | 703 / 705 |
pancreas | 76% | 1851.93 | 248 / 328 | 98% | 24.66 | 175 / 178 |
liver | 85% | 2237.97 | 193 / 226 | 83% | 13.57 | 337 / 406 |
adipose | 100% | 8648.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 13033.85 | 803 / 803 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.55 | 1 / 1 |
blood vessel | 99% | 4985.39 | 1323 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 18.02 | 42 / 45 |
eye | 0% | 0 | 0 / 0 | 93% | 21.63 | 74 / 80 |
heart | 91% | 5397.63 | 782 / 861 | 0% | 0 | 0 / 0 |
spleen | 57% | 1279.81 | 138 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 14% | 1.38 | 4 / 29 |
peripheral blood | 0% | 13.02 | 4 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0048568 | Biological process | embryonic organ development |
GO_0030307 | Biological process | positive regulation of cell growth |
GO_0035329 | Biological process | hippo signaling |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0065003 | Biological process | protein-containing complex assembly |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_1902895 | Biological process | positive regulation of miRNA transcription |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0140552 | Cellular component | TEAD-YAP complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TEAD1 |
Protein name | TEA domain transcription factor 1 Transcriptional enhancer factor TEF-1 Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) |
Synonyms | TCF13 TEF1 |
Description | FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. . |
Accessions | ENST00000527636 H0YE88 P28347 H0YEJ9 ENST00000527376.3 ENST00000527636.7 [P28347-1] ENST00000526600.1 ENST00000527575.6 ENST00000334310.10 [P28347-2] H0YCZ6 E9PKB7 |