Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 8 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 99% | 2117.72 | 1782 / 1809 | 96% | 7.50 | 453 / 472 |
| lung | 99% | 1111.54 | 571 / 578 | 91% | 7.64 | 1047 / 1155 |
| uterus | 75% | 455.06 | 127 / 170 | 96% | 12.78 | 442 / 459 |
| bladder | 71% | 1139.57 | 15 / 21 | 98% | 16.03 | 495 / 504 |
| intestine | 66% | 1484.92 | 633 / 966 | 97% | 7.79 | 509 / 527 |
| ovary | 67% | 343.61 | 121 / 180 | 86% | 3.77 | 369 / 430 |
| esophagus | 49% | 1420.48 | 709 / 1445 | 98% | 11.52 | 180 / 183 |
| breast | 64% | 373.04 | 296 / 459 | 80% | 3.80 | 899 / 1118 |
| stomach | 49% | 251.30 | 177 / 359 | 93% | 7.43 | 267 / 286 |
| brain | 53% | 320.28 | 1388 / 2642 | 83% | 3.45 | 583 / 705 |
| prostate | 93% | 962.87 | 229 / 245 | 26% | 0.82 | 133 / 502 |
| thymus | 46% | 233.31 | 301 / 653 | 66% | 5.24 | 402 / 605 |
| pancreas | 15% | 65.52 | 49 / 328 | 88% | 6.20 | 157 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 32.68 | 29 / 29 |
| spleen | 100% | 3089.89 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 17.34 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.37 | 1 / 1 |
| peripheral blood | 100% | 3599.62 | 927 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 75% | 359.38 | 194 / 258 | 20% | 0.80 | 47 / 230 |
| eye | 0% | 0 | 0 / 0 | 89% | 3.96 | 71 / 80 |
| kidney | 38% | 225.12 | 34 / 89 | 40% | 1.47 | 356 / 901 |
| adipose | 74% | 418.99 | 887 / 1204 | 0% | 0 | 0 / 0 |
| liver | 9% | 38.25 | 20 / 226 | 29% | 1.38 | 119 / 406 |
| blood vessel | 28% | 151.13 | 370 / 1335 | 0% | 0 | 0 / 0 |
| heart | 8% | 36.33 | 73 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 1.33 | 2 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045198 | Biological process | establishment of epithelial cell apical/basal polarity |
| GO_0043535 | Biological process | regulation of blood vessel endothelial cell migration |
| GO_0035020 | Biological process | regulation of Rac protein signal transduction |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0097178 | Biological process | ruffle assembly |
| GO_0006911 | Biological process | phagocytosis, engulfment |
| GO_0030834 | Biological process | regulation of actin filament depolymerization |
| GO_0007015 | Biological process | actin filament organization |
| GO_0034329 | Biological process | cell junction assembly |
| GO_0046847 | Biological process | filopodium assembly |
| GO_0071526 | Biological process | semaphorin-plexin signaling pathway |
| GO_0051058 | Biological process | negative regulation of small GTPase mediated signal transduction |
| GO_0016477 | Biological process | cell migration |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0005622 | Cellular component | intracellular anatomical structure |
| GO_0031252 | Cellular component | cell leading edge |
| GO_0005829 | Cellular component | cytosol |
| GO_0005912 | Cellular component | adherens junction |
| GO_0001891 | Cellular component | phagocytic cup |
| GO_0000145 | Cellular component | exocyst |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0005634 | Cellular component | nucleus |
| GO_0030215 | Molecular function | semaphorin receptor binding |
| GO_0005096 | Molecular function | GTPase activator activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0017124 | Molecular function | SH3 domain binding |
| Gene name | SH3BP1 |
| Protein name | SH3 domain binding protein 1 SH3-domain binding protein 1, isoform CRA_d (SH3BP1) SH3 domain-binding protein 1 |
| Synonyms | hCG_41861 |
| Description | FUNCTION: GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration . Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions . Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment . It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells . . |
| Accessions | ENST00000649107.1 F8WEQ3 Q9Y3L3 ENST00000649765.2 [Q9Y3L3-1] Q3ZTT7 ENST00000417536.5 [Q9Y3L3-2] A0A3B3IU28 ENST00000643339.1 A0A2R8Y5V0 ENST00000451997 A0A2X0SFX7 |
