SAMSN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002820Biological processnegative regulation of adaptive immune response
GO_0050732Biological processnegative regulation of peptidyl-tyrosine phosphorylation
GO_0050869Biological processnegative regulation of B cell activation
GO_0001726Cellular componentruffle
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0001784Molecular functionphosphotyrosine residue binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSAMSN1
Protein nameSAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)
SAM domain, SH3 domain and nuclear localization signals 1
SynonymsHACS1
DescriptionFUNCTION: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). .

AccessionsQ9NSI8
S6FRS6
ENST00000285670.7 [Q9NSI8-3]
ENST00000400564.5 [Q9NSI8-2]
ENST00000619120.4
S6G369
ENST00000647101.1
S6G0C9
A0A2R8Y4K8
ENST00000400566.6 [Q9NSI8-1]