RNF145 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0012505Cellular componentendomembrane system
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameRNF145
Protein nameRING finger protein 145 (EC 2.3.2.27)
Synonyms
DescriptionFUNCTION: E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately down-regulating cholesterol biosynthesis. .

AccessionsENST00000520638.1 [Q96MT1-4]
ENST00000518802.5 [Q96MT1-5]
ENST00000519865.5 [Q96MT1-1]
ENST00000274542.6 [Q96MT1-2]
ENST00000424310.7 [Q96MT1-1]
ENST00000521606.6 [Q96MT1-3]
Q96MT1