RBPMS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006396Biological processRNA processing
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0065003Biological processprotein-containing complex assembly
GO_0060395Biological processSMAD protein signal transduction
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006979Biological processresponse to oxidative stress
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0097157Molecular functionpre-mRNA intronic binding
GO_0003729Molecular functionmRNA binding
GO_1990715Molecular functionmRNA CDS binding
GO_0003723Molecular functionRNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRBPMS
Protein nameHCG2043421, isoform CRA_c (RNA binding protein, mRNA processing factor) (cDNA FLJ61582, highly similar to RNA-binding protein with multiple splicing)
RNA binding protein, mRNA processing factor
RNA-binding protein with multiple splicing (RBP-MS) (RBPMS) (Heart and RRM expressed sequence) (Hermes)
RNA binding protein with multiple splicing
SynonymsHERMES
hCG_2043421
DescriptionFUNCTION: [Isoform A]: RNA binding protein that mediates the regulation of pre-mRNA alternative splicing (AS) . Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets (By similarity). Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state (By similarity). Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats . Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher-order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP-dependent splicing complexes (By similarity). .; FUNCTION: [Isoform C]: Acts as a regulator of pre-mRNA alternative splicing (AS) (By similarity). Binds mRNA . Regulates AS of ACTN1, FLNB, although with lower efficiency than isoform A / RBPMSA (By similarity). Acts as coactivator of SMAD transcriptional activity in a TGFB1-dependent manner, possibly through increased phosphorylation of SMAD2 and SMAD3 at the C-terminal SSXS regions and promotion of the nuclear accumulation of SMAD proteins . .

AccessionsE5RJ31
ENST00000397323.9 [Q93062-1]
ENST00000519647.5
Q569H2
ENST00000522694.1
ENST00000287771.9 [Q93062-2]
ENST00000523115.5
H0YC46
H0YBU9
Q93062
ENST00000517860.5
E5RJD7
ENST00000520191.5
ENST00000339877.8 [Q93062-3]
ENST00000520161.5
E5RFP4
ENST00000519359.5
B4E3T4
ENST00000320203.8 [Q93062-1]