RAB5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0036465Biological processsynaptic vesicle recycling
GO_0051489Biological processregulation of filopodium assembly
GO_0051036Biological processregulation of endosome size
GO_0031623Biological processreceptor internalization
GO_0006897Biological processendocytosis
GO_0048169Biological processregulation of long-term neuronal synaptic plasticity
GO_0006886Biological processintracellular protein transport
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0044788Biological processmodulation by host of viral process
GO_0150093Biological processamyloid-beta clearance by transcytosis
GO_2000785Biological processregulation of autophagosome assembly
GO_0006909Biological processphagocytosis
GO_0045022Biological processearly endosome to late endosome transport
GO_0045921Biological processpositive regulation of exocytosis
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0001726Cellular componentruffle
GO_0098842Cellular componentpostsynaptic early endosome
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0032009Cellular componentearly phagosome
GO_0012505Cellular componentendomembrane system
GO_0005769Cellular componentearly endosome
GO_0036477Cellular componentsomatodendritic compartment
GO_0043195Cellular componentterminal bouton
GO_0031901Cellular componentearly endosome membrane
GO_0098559Cellular componentcytoplasmic side of early endosome membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0043679Cellular componentaxon terminus
GO_0005654Cellular componentnucleoplasm
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0045335Cellular componentphagocytic vesicle
GO_0005737Cellular componentcytoplasm
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0030424Cellular componentaxon
GO_0005768Cellular componentendosome
GO_0042470Cellular componentmelanosome
GO_0019003Molecular functionGDP binding
GO_0003925Molecular functionG protein activity
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB5A
Protein nameRas-related protein Rab-5A (EC 3.6.5.2)
RAB5A, member RAS oncogene family
SynonymsRAB5
DescriptionFUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes . Contributes to the regulation of filopodia extension . Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan . Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). .

AccessionsP20339
ENST00000422242.1 [P20339-2]
C9J3X8
ENST00000412966.5
ENST00000273047.9 [P20339-1]
F8WCY6
ENST00000446547.5
ENST00000443878.1
F8WD79