PTPN4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	37 studies	33% ± 9%	Explore
endothelial cell	18 studies	30% ± 13%	Explore
T cell	17 studies	24% ± 7%	Explore
mature NK T cell	17 studies	28% ± 8%	Explore
CD8-positive, alpha-beta T cell	16 studies	25% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	39% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	32% ± 8%	Explore
CD4-positive, alpha-beta T cell	13 studies	24% ± 8%	Explore
gamma-delta T cell	13 studies	28% ± 5%	Explore
glutamatergic neuron	12 studies	57% ± 24%	Explore
oligodendrocyte precursor cell	12 studies	46% ± 19%	Explore
astrocyte	12 studies	45% ± 16%	Explore
GABAergic neuron	11 studies	49% ± 26%	Explore
mucosal invariant T cell	11 studies	28% ± 4%	Explore
oligodendrocyte	10 studies	34% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	29% ± 6%	Explore
adipocyte	9 studies	31% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	25% ± 5%	Explore
epithelial cell	8 studies	26% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	25% ± 9%	Explore
neuron	7 studies	39% ± 15%	Explore
regulatory T cell	7 studies	18% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	23% ± 5%	Explore
interneuron	6 studies	59% ± 25%	Explore
microglial cell	6 studies	25% ± 6%	Explore
retina horizontal cell	6 studies	61% ± 18%	Explore
retinal cone cell	6 studies	24% ± 10%	Explore
type II pneumocyte	6 studies	35% ± 12%	Explore
fibroblast	6 studies	22% ± 6%	Explore
amacrine cell	5 studies	42% ± 18%	Explore
cardiac muscle cell	5 studies	31% ± 8%	Explore
Mueller cell	5 studies	29% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	18% ± 2%	Explore
endothelial cell of lymphatic vessel	5 studies	24% ± 5%	Explore
type I pneumocyte	5 studies	24% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	27% ± 7%	Explore
granule cell	4 studies	44% ± 10%	Explore
retinal bipolar neuron	4 studies	24% ± 8%	Explore
ciliated cell	4 studies	26% ± 8%	Explore
lymphocyte	4 studies	43% ± 11%	Explore
retinal rod cell	4 studies	32% ± 6%	Explore
innate lymphoid cell	4 studies	24% ± 9%	Explore
club cell	4 studies	25% ± 8%	Explore
pericyte	4 studies	19% ± 2%	Explore
basal cell	4 studies	27% ± 17%	Explore
leukocyte	3 studies	29% ± 13%	Explore
GABAergic interneuron	3 studies	47% ± 4%	Explore
macrophage	3 studies	27% ± 6%	Explore
progenitor cell	3 studies	30% ± 11%	Explore
retinal ganglion cell	3 studies	27% ± 13%	Explore
GABAergic amacrine cell	3 studies	41% ± 9%	Explore
ON-bipolar cell	3 studies	30% ± 10%	Explore
glycinergic amacrine cell	3 studies	43% ± 6%	Explore
rod bipolar cell	3 studies	34% ± 15%	Explore
hepatocyte	3 studies	38% ± 16%	Explore
retinal pigment epithelial cell	3 studies	32% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	22% ± 7%	Explore
ependymal cell	3 studies	38% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 5%	Explore
goblet cell	3 studies	31% ± 21%	Explore
transit amplifying cell	3 studies	33% ± 22%	Explore
double negative thymocyte	3 studies	25% ± 9%	Explore
mucus secreting cell	3 studies	21% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	45% ± 21%	Explore
peripheral blood	9 studies	19% ± 3%	Explore
eye	6 studies	32% ± 10%	Explore
heart	4 studies	20% ± 4%	Explore
liver	4 studies	27% ± 14%	Explore
lung	4 studies	22% ± 6%	Explore
kidney	4 studies	25% ± 6%	Explore
adipose	3 studies	25% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2310.75	2635 / 2642	100%	9.25	702 / 705
thymus	100%	2406.95	653 / 653	99%	10.33	599 / 605
esophagus	100%	923.38	1444 / 1445	99%	8.31	181 / 183
lung	100%	1166.48	576 / 578	99%	6.12	1142 / 1155
breast	100%	1447.21	459 / 459	98%	6.98	1093 / 1118
ovary	100%	1402.61	180 / 180	97%	5.73	416 / 430
uterus	100%	1303.45	170 / 170	96%	4.83	441 / 459
prostate	100%	1107.35	244 / 245	96%	5.37	483 / 502
stomach	100%	1083.97	359 / 359	96%	5.56	274 / 286
pancreas	99%	661.04	326 / 328	95%	4.66	169 / 178
intestine	100%	1007.81	966 / 966	94%	4.75	496 / 527
bladder	100%	951.14	21 / 21	92%	4.39	463 / 504
kidney	100%	1136.49	89 / 89	91%	5.35	824 / 901
adrenal gland	100%	1264.97	258 / 258	90%	4.46	208 / 230
skin	100%	1072.00	1805 / 1809	81%	3.80	384 / 472
liver	99%	606.92	224 / 226	64%	2.34	259 / 406
spleen	100%	1386.73	241 / 241	0%	0	0 / 0
adipose	100%	1184.45	1203 / 1204	0%	0	0 / 0
muscle	100%	1247.39	802 / 803	0%	0	0 / 0
blood vessel	100%	929.60	1330 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	4.61	44 / 45
peripheral blood	96%	1101.86	893 / 929	0%	0	0 / 0
heart	95%	976.74	820 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	66%	2.27	19 / 29
eye	0%	0	0 / 0	54%	2.25	43 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006470	Biological process	protein dephosphorylation
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005856	Cellular component	cytoskeleton
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0035254	Molecular function	glutamate receptor binding
GO_0004726	Molecular function	non-membrane spanning protein tyrosine phosphatase activity
GO_0008092	Molecular function	cytoskeletal protein binding
GO_0005515	Molecular function	protein binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity

IV. Literature review

[source]

Gene name	PTPN4
Protein name	Protein tyrosine phosphatase non-receptor type 4 Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1) Uncharacterized protein PTPN4
Synonyms
Description	FUNCTION: Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis . Regulates neuronal cell homeostasis by protecting neurons against apoptosis . Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction . Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton. .
Accessions	ENST00000441089.1 ENST00000420482.5 J3KQP5 ENST00000431283.1 F5H020 J3KQD3 ENST00000430976.5 ENST00000433888.5 J3QT59 Q53Q76 J3QT89 Q4ZG31 ENST00000488279.6 ENST00000263708.7 J3QT41 Q53QV5 Q580X3 P29074

PTPN4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review