PRDX4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	29 studies	35% ± 15%	Explore
plasma cell	25 studies	65% ± 21%	Explore
endothelial cell	25 studies	29% ± 13%	Explore
connective tissue cell	14 studies	41% ± 19%	Explore
pericyte	14 studies	31% ± 9%	Explore
macrophage	13 studies	22% ± 9%	Explore
epithelial cell	13 studies	44% ± 22%	Explore
myofibroblast cell	12 studies	28% ± 8%	Explore
smooth muscle cell	12 studies	28% ± 7%	Explore
plasmablast	11 studies	59% ± 20%	Explore
basal cell	10 studies	38% ± 17%	Explore
ciliated cell	10 studies	35% ± 12%	Explore
vein endothelial cell	9 studies	25% ± 8%	Explore
IgG plasma cell	9 studies	56% ± 17%	Explore
endothelial cell of lymphatic vessel	9 studies	30% ± 10%	Explore
non-classical monocyte	8 studies	22% ± 9%	Explore
IgA plasma cell	8 studies	50% ± 20%	Explore
endothelial cell of vascular tree	8 studies	23% ± 4%	Explore
secretory cell	7 studies	29% ± 13%	Explore
goblet cell	7 studies	25% ± 13%	Explore
club cell	6 studies	26% ± 11%	Explore
abnormal cell	6 studies	48% ± 9%	Explore
mesothelial cell	6 studies	36% ± 17%	Explore
progenitor cell	5 studies	35% ± 11%	Explore
myeloid cell	5 studies	26% ± 11%	Explore
capillary endothelial cell	5 studies	26% ± 9%	Explore
hematopoietic precursor cell	4 studies	25% ± 8%	Explore
pancreatic A cell	4 studies	64% ± 5%	Explore
type B pancreatic cell	4 studies	50% ± 11%	Explore
endothelial cell of artery	4 studies	22% ± 5%	Explore
transit amplifying cell	4 studies	22% ± 3%	Explore
adventitial cell	4 studies	32% ± 5%	Explore
acinar cell	4 studies	61% ± 26%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	17% ± 2%	Explore
conventional dendritic cell	4 studies	23% ± 7%	Explore
hematopoietic stem cell	4 studies	22% ± 5%	Explore
brush cell	4 studies	36% ± 23%	Explore
natural killer cell	4 studies	23% ± 6%	Explore
duct epithelial cell	3 studies	25% ± 2%	Explore
pancreatic D cell	3 studies	54% ± 8%	Explore
epithelial cell of proximal tubule	3 studies	32% ± 13%	Explore
intestinal crypt stem cell	3 studies	26% ± 7%	Explore
neural crest cell	3 studies	32% ± 5%	Explore
extravillous trophoblast	3 studies	75% ± 8%	Explore
placental villous trophoblast	3 studies	66% ± 19%	Explore
type I pneumocyte	3 studies	36% ± 7%	Explore
type II pneumocyte	3 studies	43% ± 16%	Explore
erythroblast	3 studies	34% ± 10%	Explore
neuron	3 studies	27% ± 8%	Explore
dendritic cell	3 studies	34% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	45% ± 19%	Explore
enteroendocrine cell	3 studies	36% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	17% ± 2%	Explore
hepatocyte	3 studies	52% ± 10%	Explore
CD4-positive, alpha-beta T cell	3 studies	33% ± 9%	Explore
regulatory T cell	3 studies	24% ± 8%	Explore
B cell	3 studies	40% ± 30%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	31% ± 15%	Explore
intestine	6 studies	31% ± 10%	Explore
pancreas	5 studies	51% ± 18%	Explore
placenta	4 studies	46% ± 24%	Explore
breast	4 studies	20% ± 2%	Explore
liver	4 studies	29% ± 11%	Explore
peripheral blood	3 studies	17% ± 2%	Explore
kidney	3 studies	24% ± 6%	Explore
uterus	3 studies	36% ± 16%	Explore
skin	3 studies	16% ± 1%	Explore
brain	3 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	3247.01	180 / 180	100%	184.50	430 / 430
pancreas	100%	12939.46	328 / 328	100%	153.43	178 / 178
stomach	100%	2827.70	359 / 359	100%	196.32	286 / 286
liver	100%	6131.78	225 / 226	100%	185.18	406 / 406
intestine	100%	1962.01	965 / 966	100%	221.64	525 / 527
uterus	100%	2790.34	170 / 170	99%	192.61	456 / 459
breast	100%	3087.09	459 / 459	99%	174.05	1108 / 1118
skin	100%	3853.49	1802 / 1809	99%	209.73	469 / 472
esophagus	100%	2108.34	1443 / 1445	99%	113.82	181 / 183
lung	99%	2092.94	571 / 578	100%	200.88	1153 / 1155
prostate	100%	1878.96	244 / 245	99%	224.10	496 / 502
bladder	100%	2081.05	21 / 21	98%	189.49	495 / 504
thymus	100%	2253.94	652 / 653	98%	98.80	595 / 605
kidney	100%	1653.03	89 / 89	96%	139.28	862 / 901
adrenal gland	100%	3494.17	257 / 258	95%	154.70	218 / 230
brain	78%	744.53	2059 / 2642	98%	125.91	690 / 705
adipose	100%	3275.25	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	109.83	29 / 29
tonsil	0%	0	0 / 0	100%	148.05	45 / 45
ureter	0%	0	0 / 0	100%	70.82	1 / 1
blood vessel	100%	3016.69	1330 / 1335	0%	0	0 / 0
spleen	100%	2910.86	240 / 241	0%	0	0 / 0
heart	97%	2423.74	831 / 861	0%	0	0 / 0
muscle	93%	1036.19	746 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	90%	94.42	72 / 80
peripheral blood	46%	947.68	430 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045454	Biological process	cell redox homeostasis
GO_0007283	Biological process	spermatogenesis
GO_0033554	Biological process	cellular response to stress
GO_0098869	Biological process	cellular oxidant detoxification
GO_0022417	Biological process	protein maturation by protein folding
GO_0042744	Biological process	hydrogen peroxide catabolic process
GO_0030198	Biological process	extracellular matrix organization
GO_2000255	Biological process	negative regulation of male germ cell proliferation
GO_0007252	Biological process	I-kappaB phosphorylation
GO_0008584	Biological process	male gonad development
GO_0006979	Biological process	response to oxidative stress
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0034774	Cellular component	secretory granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0060090	Molecular function	molecular adaptor activity
GO_0008379	Molecular function	thioredoxin peroxidase activity
GO_0042802	Molecular function	identical protein binding
GO_0140313	Molecular function	molecular sequestering activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRDX4
Protein name	Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) Peroxiredoxin 4
Synonyms	hCG_17636 HEL-S-97n
Description	FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. .
Accessions	ENST00000439422.1 A6NG45 H7C3T4 A6NJJ0 ENST00000379341.9 Q13162 ENST00000379349.5 V9HW63 ENST00000379331.3

PRDX4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review