PPP1R11 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	14 studies	18% ± 3%	Explore
regulatory T cell	12 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	10 studies	19% ± 3%	Explore
CD8-positive, alpha-beta T cell	10 studies	19% ± 2%	Explore
non-classical monocyte	9 studies	25% ± 8%	Explore
gamma-delta T cell	9 studies	21% ± 5%	Explore
B cell	9 studies	19% ± 3%	Explore
classical monocyte	7 studies	23% ± 7%	Explore
mature NK T cell	7 studies	17% ± 1%	Explore
memory B cell	7 studies	19% ± 5%	Explore
naive B cell	7 studies	18% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	21% ± 5%	Explore
mucosal invariant T cell	6 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	20% ± 4%	Explore
T cell	6 studies	18% ± 2%	Explore
conventional dendritic cell	5 studies	28% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
endothelial cell	5 studies	30% ± 8%	Explore
epithelial cell	5 studies	37% ± 13%	Explore
capillary endothelial cell	5 studies	18% ± 3%	Explore
ciliated cell	5 studies	26% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	20% ± 5%	Explore
smooth muscle cell	4 studies	18% ± 2%	Explore
pericyte	4 studies	19% ± 3%	Explore
fibroblast	4 studies	24% ± 8%	Explore
innate lymphoid cell	4 studies	19% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 3%	Explore
pancreatic A cell	3 studies	34% ± 7%	Explore
retinal ganglion cell	3 studies	51% ± 26%	Explore
abnormal cell	3 studies	31% ± 5%	Explore
endothelial cell of vascular tree	3 studies	18% ± 1%	Explore
exhausted T cell	3 studies	17% ± 2%	Explore
dendritic cell	3 studies	31% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
goblet cell	3 studies	24% ± 3%	Explore
T follicular helper cell	3 studies	17% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	21% ± 4%	Explore
mast cell	3 studies	21% ± 7%	Explore
double negative thymocyte	3 studies	22% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	20% ± 3%	Explore
lung	6 studies	23% ± 6%	Explore
pancreas	3 studies	35% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3633.08	1445 / 1445	100%	100.30	183 / 183
intestine	100%	3932.63	966 / 966	100%	114.00	527 / 527
ovary	100%	2929.39	180 / 180	100%	130.51	430 / 430
pancreas	100%	1797.17	328 / 328	100%	97.60	178 / 178
prostate	100%	3520.13	245 / 245	100%	104.26	502 / 502
stomach	100%	3365.75	359 / 359	100%	108.53	286 / 286
brain	100%	3007.07	2641 / 2642	100%	97.23	705 / 705
skin	100%	2972.82	1808 / 1809	100%	133.40	472 / 472
lung	100%	3355.67	578 / 578	100%	100.77	1153 / 1155
breast	100%	3153.94	459 / 459	100%	116.83	1116 / 1118
thymus	100%	3355.58	653 / 653	100%	96.60	603 / 605
kidney	100%	3482.55	89 / 89	100%	83.70	898 / 901
bladder	100%	3803.81	21 / 21	100%	98.49	502 / 504
uterus	100%	3565.93	170 / 170	99%	93.24	456 / 459
adrenal gland	100%	2909.06	258 / 258	99%	85.20	228 / 230
liver	100%	1773.70	225 / 226	99%	73.93	403 / 406
adipose	100%	3078.44	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	147.88	80 / 80
lymph node	0%	0	0 / 0	100%	70.56	29 / 29
spleen	100%	2886.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	79.88	45 / 45
ureter	0%	0	0 / 0	100%	63.06	1 / 1
blood vessel	100%	3604.76	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	4258.84	927 / 929	0%	0	0 / 0
muscle	100%	2158.70	801 / 803	0%	0	0 / 0
heart	99%	2283.67	850 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0001818	Biological process	negative regulation of cytokine production
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004864	Molecular function	protein phosphatase inhibitor activity
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0019902	Molecular function	phosphatase binding
GO_0008157	Molecular function	protein phosphatase 1 binding
GO_0005515	Molecular function	protein binding
GO_0004865	Molecular function	protein serine/threonine phosphatase inhibitor activity

IV. Literature review

[source]

Gene name	PPP1R11
Protein name	E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) E3 ubiquitin-protein ligase PPP1R11 (Protein phosphatase 1 regulatory subunit 11)
Synonyms	TCTE5 HCGV hCG_23774
Description	FUNCTION: Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 . Inhibitor of protein phosphatase 1 . .
Accessions	ENST00000455887.1 ENST00000376773.5 ENST00000376772.8 ENST00000436591.6 ENST00000439463.5 ENST00000446310.5 ENST00000449435.1 ENST00000417223.5 A2BEK1 ENST00000436833.5 ENST00000400654.1 ENST00000433662.5 ENST00000422273.5 ENST00000437937.6 ENST00000376763.5 ENST00000448550.5 ENST00000400658.5 ENST00000450177.1 ENST00000431977.6 ENST00000414618.5 ENST00000376758.1 ENST00000428563.5 ENST00000412077.5 ENST00000434591.5 ENST00000376765.6 ENST00000414032.5 ENST00000444101.5 ENST00000458506.5 ENST00000383612.8 ENST00000455350.5 ENST00000433942.5 ENST00000444994.1 ENST00000437171.5 Q5SRK2 ENST00000400657.5 ENST00000418211.5 ENST00000448210.5 ENST00000449087.5 ENST00000431424.6 ENST00000400655.5 ENST00000452227.1 ENST00000441553.5 ENST00000452679.6 O60927 ENST00000430959.1 ENST00000430828.5 ENST00000376769.6 ENST00000429382.5 ENST00000448378.6 ENST00000400656.5 ENST00000451993.5

PPP1R11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review