PHF11 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
regulatory T cell	17 studies	22% ± 5%	Explore
natural killer cell	13 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	12 studies	22% ± 7%	Explore
T cell	11 studies	18% ± 2%	Explore
naive B cell	11 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	11 studies	20% ± 5%	Explore
gamma-delta T cell	11 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	19% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	21% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	23% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	20% ± 3%	Explore
B cell	9 studies	22% ± 4%	Explore
endothelial cell	9 studies	22% ± 4%	Explore
mucosal invariant T cell	9 studies	20% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	19% ± 3%	Explore
macrophage	8 studies	21% ± 5%	Explore
classical monocyte	7 studies	25% ± 7%	Explore
non-classical monocyte	7 studies	25% ± 8%	Explore
mature NK T cell	7 studies	21% ± 5%	Explore
memory B cell	7 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	22% ± 4%	Explore
plasmacytoid dendritic cell	5 studies	26% ± 7%	Explore
monocyte	4 studies	22% ± 1%	Explore
conventional dendritic cell	4 studies	31% ± 14%	Explore
exhausted T cell	4 studies	24% ± 8%	Explore
glutamatergic neuron	4 studies	26% ± 8%	Explore
epithelial cell	4 studies	36% ± 10%	Explore
fibroblast	4 studies	23% ± 3%	Explore
ciliated cell	4 studies	26% ± 7%	Explore
T follicular helper cell	4 studies	20% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	19% ± 4%	Explore
astrocyte	4 studies	22% ± 6%	Explore
microglial cell	4 studies	24% ± 6%	Explore
dendritic cell	4 studies	31% ± 15%	Explore
oligodendrocyte	4 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	18% ± 1%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 2%	Explore
leukocyte	3 studies	22% ± 5%	Explore
myeloid cell	3 studies	24% ± 7%	Explore
precursor B cell	3 studies	19% ± 2%	Explore
lymphocyte	3 studies	23% ± 3%	Explore
oligodendrocyte precursor cell	3 studies	21% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	27% ± 6%	Explore
basal cell	3 studies	24% ± 2%	Explore
double negative thymocyte	3 studies	23% ± 4%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	22% ± 6%	Explore
brain	4 studies	24% ± 6%	Explore
lung	3 studies	21% ± 4%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2197.42	1445 / 1445	100%	18.83	183 / 183
thymus	100%	3801.23	653 / 653	100%	24.40	605 / 605
lung	100%	2798.32	578 / 578	100%	17.84	1153 / 1155
breast	100%	2917.00	459 / 459	100%	25.96	1113 / 1118
ovary	100%	2131.65	180 / 180	100%	16.06	428 / 430
kidney	100%	2344.80	89 / 89	99%	18.89	896 / 901
bladder	100%	2505.33	21 / 21	99%	20.83	501 / 504
stomach	100%	1860.69	359 / 359	99%	19.64	283 / 286
pancreas	100%	1477.53	328 / 328	99%	21.31	176 / 178
prostate	100%	2829.33	245 / 245	99%	13.11	496 / 502
intestine	100%	2382.91	966 / 966	98%	18.94	519 / 527
uterus	100%	2638.92	170 / 170	98%	19.11	451 / 459
adrenal gland	100%	3232.38	258 / 258	97%	11.74	222 / 230
liver	100%	1240.55	226 / 226	95%	10.11	386 / 406
skin	100%	2098.28	1809 / 1809	85%	11.08	399 / 472
brain	94%	1125.50	2487 / 2642	89%	11.15	628 / 705
adipose	100%	2609.99	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	31.23	29 / 29
spleen	100%	3931.04	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	15.54	45 / 45
ureter	0%	0	0 / 0	100%	6.43	1 / 1
blood vessel	100%	2641.64	1334 / 1335	0%	0	0 / 0
heart	100%	1186.82	857 / 861	0%	0	0 / 0
peripheral blood	99%	2484.05	919 / 929	0%	0	0 / 0
muscle	85%	627.23	683 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	80%	7.82	64 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0