Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 20 studies | 47% ± 18% | |
| astrocyte | 19 studies | 74% ± 18% | |
| fibroblast | 17 studies | 53% ± 21% | |
| pericyte | 16 studies | 55% ± 25% | |
| oligodendrocyte precursor cell | 14 studies | 64% ± 18% | |
| smooth muscle cell | 13 studies | 51% ± 21% | |
| GABAergic neuron | 11 studies | 50% ± 20% | |
| basal cell | 10 studies | 49% ± 29% | |
| adipocyte | 10 studies | 62% ± 21% | |
| ciliated cell | 10 studies | 37% ± 24% | |
| epithelial cell | 9 studies | 45% ± 22% | |
| mesothelial cell | 8 studies | 52% ± 21% | |
| endothelial cell of lymphatic vessel | 8 studies | 44% ± 15% | |
| club cell | 7 studies | 46% ± 27% | |
| interneuron | 6 studies | 50% ± 21% | |
| cardiac muscle cell | 6 studies | 58% ± 24% | |
| glutamatergic neuron | 5 studies | 41% ± 19% | |
| microglial cell | 5 studies | 59% ± 27% | |
| amacrine cell | 5 studies | 35% ± 11% | |
| type I pneumocyte | 5 studies | 78% ± 7% | |
| type II pneumocyte | 5 studies | 72% ± 10% | |
| cholangiocyte | 4 studies | 72% ± 15% | |
| hepatocyte | 4 studies | 73% ± 23% | |
| neuron | 4 studies | 59% ± 18% | |
| Mueller cell | 4 studies | 82% ± 16% | |
| retina horizontal cell | 4 studies | 42% ± 16% | |
| retinal cone cell | 4 studies | 70% ± 21% | |
| retinal rod cell | 4 studies | 59% ± 12% | |
| myofibroblast cell | 4 studies | 47% ± 29% | |
| goblet cell | 4 studies | 40% ± 25% | |
| oligodendrocyte | 4 studies | 32% ± 21% | |
| hepatic stellate cell | 3 studies | 71% ± 14% | |
| differentiation-committed oligodendrocyte precursor | 3 studies | 57% ± 13% | |
| GABAergic interneuron | 3 studies | 47% ± 7% | |
| glial cell | 3 studies | 43% ± 20% | |
| granule cell | 3 studies | 47% ± 32% | |
| squamous epithelial cell | 3 studies | 51% ± 26% | |
| GABAergic amacrine cell | 3 studies | 40% ± 13% | |
| glycinergic amacrine cell | 3 studies | 33% ± 10% | |
| endothelial cell of vascular tree | 3 studies | 27% ± 8% | |
| retinal pigment epithelial cell | 3 studies | 55% ± 27% | |
| connective tissue cell | 3 studies | 54% ± 16% | |
| ependymal cell | 3 studies | 82% ± 5% | |
| capillary endothelial cell | 3 studies | 49% ± 7% | |
| respiratory goblet cell | 3 studies | 68% ± 24% | |
| muscle cell | 3 studies | 47% ± 18% | |
| transit amplifying cell | 3 studies | 44% ± 37% | |
| mucus secreting cell | 3 studies | 62% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 3432.77 | 245 / 245 | 100% | 30.06 | 501 / 502 |
| ovary | 100% | 6315.94 | 180 / 180 | 100% | 37.20 | 429 / 430 |
| pancreas | 100% | 2397.73 | 327 / 328 | 100% | 28.32 | 178 / 178 |
| lung | 99% | 3381.03 | 575 / 578 | 100% | 42.17 | 1153 / 1155 |
| intestine | 100% | 5335.47 | 964 / 966 | 99% | 26.72 | 524 / 527 |
| uterus | 100% | 4435.62 | 170 / 170 | 99% | 42.46 | 455 / 459 |
| bladder | 100% | 4820.05 | 21 / 21 | 99% | 33.54 | 499 / 504 |
| esophagus | 100% | 7319.95 | 1445 / 1445 | 98% | 47.73 | 180 / 183 |
| stomach | 100% | 3501.89 | 358 / 359 | 99% | 26.58 | 282 / 286 |
| breast | 100% | 3369.57 | 458 / 459 | 98% | 30.97 | 1100 / 1118 |
| kidney | 100% | 3276.16 | 89 / 89 | 98% | 36.62 | 884 / 901 |
| thymus | 100% | 2713.38 | 651 / 653 | 98% | 28.07 | 595 / 605 |
| liver | 96% | 1561.20 | 216 / 226 | 99% | 24.08 | 400 / 406 |
| skin | 100% | 7581.18 | 1808 / 1809 | 87% | 20.07 | 411 / 472 |
| adrenal gland | 100% | 3272.46 | 257 / 258 | 83% | 13.16 | 190 / 230 |
| brain | 70% | 1205.68 | 1846 / 2642 | 98% | 26.81 | 693 / 705 |
| muscle | 100% | 5659.21 | 803 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 52.42 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.82 | 1 / 1 |
| blood vessel | 100% | 2969.80 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2929.65 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 20.54 | 77 / 80 |
| heart | 90% | 2080.06 | 779 / 861 | 0% | 0 | 0 / 0 |
| spleen | 49% | 611.13 | 119 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 1.12 | 3 / 29 |
| peripheral blood | 9% | 210.91 | 80 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030010 | Biological process | establishment of cell polarity |
| GO_0090162 | Biological process | establishment of epithelial cell polarity |
| GO_0008356 | Biological process | asymmetric cell division |
| GO_0007163 | Biological process | establishment or maintenance of cell polarity |
| GO_0007155 | Biological process | cell adhesion |
| GO_0006612 | Biological process | protein targeting to membrane |
| GO_0022011 | Biological process | myelination in peripheral nervous system |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0007409 | Biological process | axonogenesis |
| GO_0010801 | Biological process | negative regulation of peptidyl-threonine phosphorylation |
| GO_0070830 | Biological process | bicellular tight junction assembly |
| GO_0000226 | Biological process | microtubule cytoskeleton organization |
| GO_0008104 | Biological process | protein localization |
| GO_0031643 | Biological process | positive regulation of myelination |
| GO_0045197 | Biological process | establishment or maintenance of epithelial cell apical/basal polarity |
| GO_0051660 | Biological process | establishment of centrosome localization |
| GO_0007205 | Biological process | protein kinase C-activating G protein-coupled receptor signaling pathway |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0070160 | Cellular component | tight junction |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0012505 | Cellular component | endomembrane system |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0043296 | Cellular component | apical junction complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005912 | Cellular component | adherens junction |
| GO_0005938 | Cellular component | cell cortex |
| GO_0120157 | Cellular component | PAR polarity complex |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0033269 | Cellular component | internode region of axon |
| GO_0030054 | Cellular component | cell junction |
| GO_0005547 | Molecular function | phosphatidylinositol-3,4,5-trisphosphate binding |
| GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
| GO_0035091 | Molecular function | phosphatidylinositol binding |
| GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PARD3 |
| Protein name | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) Par-3 family cell polarity regulator |
| Synonyms | PAR3 PAR3A |
| Description | FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes . Seems to play a central role in the formation of epithelial tight junctions . Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins . Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons . . |
| Accessions | Q5VWU8 ENST00000545260.5 [Q8TEW0-3] ENST00000374789.8 [Q8TEW0-1] F5GZI3 Q5VWV2 ENST00000696673.1 ENST00000374773.6 A0A8Q3WLH5 ENST00000374788.8 [Q8TEW0-2] ENST00000374768.1 ENST00000340077.9 [Q8TEW0-8] B1AP52 ENST00000374794.8 [Q8TEW0-5] Q8TEW0 ENST00000346874.9 [Q8TEW0-4] ENST00000350537.9 [Q8TEW0-6] ENST00000374790.8 ENST00000374776.6 [Q8TEW0-9] ENST00000545693.5 [Q8TEW0-11] ENST00000544292.5 |