PARD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0090162Biological processestablishment of epithelial cell polarity
GO_0008356Biological processasymmetric cell division
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0007155Biological processcell adhesion
GO_0006612Biological processprotein targeting to membrane
GO_0022011Biological processmyelination in peripheral nervous system
GO_0065003Biological processprotein-containing complex assembly
GO_0007409Biological processaxonogenesis
GO_0010801Biological processnegative regulation of peptidyl-threonine phosphorylation
GO_0070830Biological processbicellular tight junction assembly
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0008104Biological processprotein localization
GO_0031643Biological processpositive regulation of myelination
GO_0045197Biological processestablishment or maintenance of epithelial cell apical/basal polarity
GO_0051660Biological processestablishment of centrosome localization
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0016324Cellular componentapical plasma membrane
GO_0070160Cellular componenttight junction
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0012505Cellular componentendomembrane system
GO_0005911Cellular componentcell-cell junction
GO_0043296Cellular componentapical junction complex
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005938Cellular componentcell cortex
GO_0120157Cellular componentPAR polarity complex
GO_0005923Cellular componentbicellular tight junction
GO_0033269Cellular componentinternode region of axon
GO_0030054Cellular componentcell junction
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePARD3
Protein namePartitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)
Par-3 family cell polarity regulator
SynonymsPAR3
PAR3A
DescriptionFUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes . Seems to play a central role in the formation of epithelial tight junctions . Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins . Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons . .

AccessionsQ5VWU8
ENST00000545260.5 [Q8TEW0-3]
ENST00000374789.8 [Q8TEW0-1]
F5GZI3
Q5VWV2
ENST00000696673.1
ENST00000374773.6
A0A8Q3WLH5
ENST00000374788.8 [Q8TEW0-2]
ENST00000374768.1
ENST00000340077.9 [Q8TEW0-8]
B1AP52
ENST00000374794.8 [Q8TEW0-5]
Q8TEW0
ENST00000346874.9 [Q8TEW0-4]
ENST00000350537.9 [Q8TEW0-6]
ENST00000374790.8
ENST00000374776.6 [Q8TEW0-9]
ENST00000545693.5 [Q8TEW0-11]
ENST00000544292.5