PACS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	20 studies	36% ± 17%	Explore
astrocyte	16 studies	40% ± 16%	Explore
microglial cell	13 studies	43% ± 13%	Explore
glutamatergic neuron	12 studies	49% ± 23%	Explore
macrophage	12 studies	34% ± 16%	Explore
B cell	11 studies	36% ± 15%	Explore
oligodendrocyte precursor cell	11 studies	34% ± 12%	Explore
fibroblast	11 studies	30% ± 9%	Explore
GABAergic neuron	10 studies	45% ± 21%	Explore
T cell	9 studies	34% ± 16%	Explore
pericyte	8 studies	32% ± 15%	Explore
adipocyte	8 studies	33% ± 5%	Explore
natural killer cell	7 studies	34% ± 12%	Explore
CD4-positive, alpha-beta T cell	7 studies	33% ± 14%	Explore
epithelial cell	7 studies	32% ± 16%	Explore
dendritic cell	7 studies	37% ± 11%	Explore
mast cell	7 studies	26% ± 12%	Explore
basal cell	7 studies	39% ± 22%	Explore
neuron	6 studies	43% ± 16%	Explore
interneuron	6 studies	53% ± 13%	Explore
retina horizontal cell	6 studies	44% ± 20%	Explore
regulatory T cell	6 studies	36% ± 20%	Explore
endothelial cell of lymphatic vessel	6 studies	31% ± 9%	Explore
monocyte	6 studies	29% ± 9%	Explore
smooth muscle cell	6 studies	25% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	29% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	31% ± 14%	Explore
CD8-positive, alpha-beta T cell	5 studies	31% ± 11%	Explore
cardiac muscle cell	5 studies	38% ± 9%	Explore
myeloid cell	5 studies	30% ± 8%	Explore
oligodendrocyte	5 studies	25% ± 11%	Explore
type I pneumocyte	5 studies	35% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	31% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	39% ± 13%	Explore
non-classical monocyte	4 studies	22% ± 5%	Explore
granule cell	4 studies	33% ± 7%	Explore
lymphocyte	4 studies	51% ± 19%	Explore
amacrine cell	4 studies	25% ± 2%	Explore
retinal cone cell	4 studies	42% ± 8%	Explore
retinal rod cell	4 studies	45% ± 13%	Explore
club cell	4 studies	31% ± 9%	Explore
hepatic stellate cell	3 studies	36% ± 17%	Explore
classical monocyte	3 studies	20% ± 2%	Explore
mature NK T cell	3 studies	31% ± 19%	Explore
GABAergic interneuron	3 studies	44% ± 9%	Explore
plasma cell	3 studies	21% ± 7%	Explore
mesothelial cell	3 studies	28% ± 5%	Explore
GABAergic amacrine cell	3 studies	29% ± 4%	Explore
Mueller cell	3 studies	24% ± 5%	Explore
glycinergic amacrine cell	3 studies	22% ± 3%	Explore
retinal ganglion cell	3 studies	34% ± 6%	Explore
rod bipolar cell	3 studies	42% ± 18%	Explore
endothelial cell of vascular tree	3 studies	30% ± 12%	Explore
retinal pigment epithelial cell	3 studies	36% ± 18%	Explore
ependymal cell	3 studies	38% ± 18%	Explore
alveolar macrophage	3 studies	34% ± 6%	Explore
capillary endothelial cell	3 studies	31% ± 9%	Explore
ciliated cell	3 studies	39% ± 7%	Explore
respiratory goblet cell	3 studies	51% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	26% ± 5%	Explore
naive B cell	3 studies	27% ± 8%	Explore
leukocyte	3 studies	58% ± 12%	Explore
abnormal cell	3 studies	30% ± 12%	Explore
mucus secreting cell	3 studies	49% ± 23%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	40% ± 18%	Explore
lung	6 studies	23% ± 8%	Explore
eye	5 studies	41% ± 13%	Explore
heart	4 studies	29% ± 7%	Explore
peripheral blood	3 studies	21% ± 2%	Explore
adipose	3 studies	29% ± 3%	Explore
kidney	3 studies	24% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6031.30	1445 / 1445	100%	67.83	183 / 183
prostate	100%	7531.51	245 / 245	100%	59.92	502 / 502
skin	100%	5516.89	1808 / 1809	100%	42.34	472 / 472
thymus	100%	7655.10	653 / 653	100%	63.14	604 / 605
uterus	100%	5539.71	170 / 170	100%	44.77	458 / 459
ovary	100%	6329.57	180 / 180	100%	61.46	428 / 430
breast	100%	5822.88	459 / 459	99%	51.47	1111 / 1118
kidney	100%	5309.19	89 / 89	99%	37.92	894 / 901
pancreas	99%	3183.77	325 / 328	100%	47.27	178 / 178
lung	100%	6240.37	577 / 578	99%	44.82	1145 / 1155
brain	99%	5485.26	2618 / 2642	100%	41.11	703 / 705
stomach	100%	4173.74	359 / 359	98%	34.45	281 / 286
bladder	100%	7032.76	21 / 21	98%	41.12	492 / 504
intestine	99%	5102.57	959 / 966	98%	27.34	515 / 527
adrenal gland	100%	4741.29	258 / 258	91%	20.70	210 / 230
liver	56%	964.67	126 / 226	73%	15.82	296 / 406
adipose	100%	5990.01	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8094.39	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	51.13	80 / 80
lymph node	0%	0	0 / 0	100%	56.49	29 / 29
spleen	100%	7098.20	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	48.75	45 / 45
ureter	0%	0	0 / 0	100%	155.20	1 / 1
peripheral blood	99%	10403.93	921 / 929	0%	0	0 / 0
heart	99%	5756.81	851 / 861	0%	0	0 / 0
muscle	98%	2638.98	787 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002260	Biological process	lymphocyte homeostasis
GO_0072659	Biological process	protein localization to plasma membrane
GO_0034067	Biological process	protein localization to Golgi apparatus
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0030137	Cellular component	COPI-coated vesicle
GO_0005515	Molecular function	protein binding
GO_0044325	Molecular function	transmembrane transporter binding

IV. Literature review

[source]

Gene name	PACS1
Protein name	Phosphofurin acidic cluster sorting protein 1 (PACS-1) Phosphofurin acidic cluster sorting protein 1
Synonyms	KIAA1175
Description	FUNCTION: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). .
Accessions	ENST00000524815.5 ENST00000529677.1 E9PNG7 ENST00000528935.1 H0YF56 E9PPK2 ENST00000320580.9 [Q6VY07-1] ENST00000524784.1 B4DF77 H0YCU5 Q6VY07 H0YE62 ENST00000529757.5 ENST00000533756.5 E9PSG7 ENST00000531298.5 E9PSE1 E9PNZ9 ENST00000531597.1 ENST00000527380.1

PACS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review