NAA10 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	20 studies	32% ± 14%	Explore
natural killer cell	17 studies	24% ± 7%	Explore
pericyte	13 studies	23% ± 6%	Explore
smooth muscle cell	13 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	12 studies	30% ± 10%	Explore
B cell	11 studies	25% ± 7%	Explore
CD4-positive, alpha-beta T cell	11 studies	28% ± 11%	Explore
capillary endothelial cell	11 studies	21% ± 5%	Explore
fibroblast	11 studies	21% ± 10%	Explore
mast cell	10 studies	19% ± 3%	Explore
endothelial cell of artery	10 studies	29% ± 9%	Explore
vein endothelial cell	10 studies	23% ± 7%	Explore
T cell	9 studies	20% ± 6%	Explore
plasma cell	9 studies	33% ± 14%	Explore
non-classical monocyte	9 studies	28% ± 13%	Explore
mature NK T cell	9 studies	20% ± 4%	Explore
regulatory T cell	9 studies	27% ± 10%	Explore
conventional dendritic cell	8 studies	32% ± 19%	Explore
classical monocyte	8 studies	24% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	24% ± 7%	Explore
epithelial cell	7 studies	38% ± 17%	Explore
basal cell	7 studies	30% ± 15%	Explore
endothelial cell of vascular tree	7 studies	24% ± 7%	Explore
plasmacytoid dendritic cell	7 studies	26% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	21% ± 3%	Explore
gamma-delta T cell	6 studies	27% ± 14%	Explore
memory B cell	6 studies	21% ± 6%	Explore
plasmablast	5 studies	52% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	24% ± 3%	Explore
connective tissue cell	5 studies	21% ± 6%	Explore
naive B cell	5 studies	16% ± 1%	Explore
mucosal invariant T cell	5 studies	19% ± 2%	Explore
ciliated cell	5 studies	38% ± 10%	Explore
endothelial cell of lymphatic vessel	5 studies	23% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	23% ± 6%	Explore
hematopoietic precursor cell	4 studies	34% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
myofibroblast cell	4 studies	23% ± 6%	Explore
erythroblast	4 studies	34% ± 19%	Explore
macrophage	4 studies	32% ± 6%	Explore
myeloid cell	4 studies	25% ± 11%	Explore
dendritic cell	4 studies	35% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	26% ± 6%	Explore
exhausted T cell	3 studies	39% ± 7%	Explore
glomerular endothelial cell	3 studies	26% ± 2%	Explore
epithelial cell of proximal tubule	3 studies	16% ± 1%	Explore
leukocyte	3 studies	23% ± 7%	Explore
neural crest cell	3 studies	21% ± 0%	Explore
monocyte	3 studies	22% ± 5%	Explore
neuron	3 studies	38% ± 18%	Explore
abnormal cell	3 studies	29% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	37% ± 21%	Explore
enteroendocrine cell	3 studies	31% ± 13%	Explore
goblet cell	3 studies	26% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	30% ± 11%	Explore
T-helper 17 cell	3 studies	29% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	32% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	26% ± 10%	Explore
lung	8 studies	27% ± 12%	Explore
kidney	4 studies	17% ± 1%	Explore
intestine	4 studies	23% ± 11%	Explore
liver	3 studies	33% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	3099.20	258 / 258	100%	16.94	230 / 230
esophagus	100%	2894.53	1445 / 1445	100%	13.66	183 / 183
uterus	100%	2950.26	170 / 170	100%	25.88	459 / 459
brain	100%	2358.54	2639 / 2642	100%	17.40	705 / 705
ovary	100%	2012.53	180 / 180	100%	13.55	428 / 430
thymus	100%	2185.39	653 / 653	100%	13.75	602 / 605
pancreas	100%	1719.24	328 / 328	99%	15.57	177 / 178
intestine	100%	2635.10	966 / 966	99%	23.51	524 / 527
prostate	100%	2703.91	245 / 245	99%	16.32	499 / 502
skin	100%	2631.67	1809 / 1809	99%	21.99	469 / 472
bladder	100%	2926.95	21 / 21	99%	22.42	500 / 504
lung	100%	2625.39	578 / 578	99%	14.34	1140 / 1155
stomach	100%	2159.95	359 / 359	99%	19.53	282 / 286
liver	100%	1577.12	226 / 226	98%	13.53	396 / 406
breast	100%	2796.07	459 / 459	97%	13.47	1083 / 1118
kidney	100%	2589.79	89 / 89	97%	10.45	870 / 901
adipose	100%	2837.50	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	19.55	80 / 80
lymph node	0%	0	0 / 0	100%	36.38	29 / 29
muscle	100%	3635.76	803 / 803	0%	0	0 / 0
spleen	100%	3353.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.27	45 / 45
ureter	0%	0	0 / 0	100%	25.28	1 / 1
blood vessel	100%	2759.93	1334 / 1335	0%	0	0 / 0
heart	100%	2238.96	859 / 861	0%	0	0 / 0
peripheral blood	99%	1882.62	921 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000719	Biological process	negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric
GO_0006475	Biological process	internal protein amino acid acetylation
GO_0006473	Biological process	protein acetylation
GO_0051276	Biological process	chromosome organization
GO_0006474	Biological process	N-terminal protein amino acid acetylation
GO_0005730	Cellular component	nucleolus
GO_0031415	Cellular component	NatA complex
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_1990190	Molecular function	peptide-glutamate-alpha-N-acetyltransferase activity
GO_0043022	Molecular function	ribosome binding
GO_0016407	Molecular function	acetyltransferase activity
GO_0008080	Molecular function	N-acetyltransferase activity
GO_0004596	Molecular function	peptide alpha-N-acetyltransferase activity
GO_1990189	Molecular function	peptide-serine-alpha-N-acetyltransferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NAA10
Protein name	N-terminal amino-acid N(alpha)-acetyltransferase NatA (EC 2.3.1.255) N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10)
Synonyms	ARD1A TE2 ARD1
Description	FUNCTION: Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity . Acetylates amino termini that are devoid of initiator methionine . The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation . Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration . Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development . Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX . Acetylates HIST1H4A . Acts as a negative regulator of sister chromatid cohesion during mitosis . .
Accessions	C9JW55 A8MWP7 ENST00000370009.5 [P41227-2] F8W808 ENST00000370015.8 C9JN83 ENST00000432089.1 P41227 ENST00000370011.7 ENST00000393712.7 ENST00000464845.6 [P41227-1]

NAA10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review