MICU2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	15 studies	28% ± 13%	Explore
oligodendrocyte	12 studies	33% ± 12%	Explore
astrocyte	12 studies	31% ± 14%	Explore
microglial cell	11 studies	27% ± 9%	Explore
fibroblast	11 studies	25% ± 8%	Explore
natural killer cell	10 studies	20% ± 4%	Explore
glutamatergic neuron	10 studies	49% ± 25%	Explore
macrophage	10 studies	29% ± 11%	Explore
oligodendrocyte precursor cell	10 studies	30% ± 13%	Explore
B cell	9 studies	21% ± 5%	Explore
ciliated cell	9 studies	26% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	19% ± 2%	Explore
GABAergic neuron	8 studies	53% ± 21%	Explore
CD8-positive, alpha-beta T cell	7 studies	18% ± 3%	Explore
memory B cell	7 studies	18% ± 3%	Explore
myeloid cell	7 studies	23% ± 4%	Explore
epithelial cell	7 studies	37% ± 13%	Explore
adipocyte	7 studies	23% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	18% ± 2%	Explore
neuron	6 studies	42% ± 15%	Explore
interneuron	6 studies	54% ± 21%	Explore
retina horizontal cell	6 studies	39% ± 15%	Explore
dendritic cell	6 studies	26% ± 9%	Explore
Mueller cell	6 studies	26% ± 8%	Explore
T cell	6 studies	22% ± 4%	Explore
type I pneumocyte	6 studies	24% ± 7%	Explore
type II pneumocyte	6 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	18% ± 2%	Explore
kidney loop of Henle epithelial cell	5 studies	22% ± 3%	Explore
retinal ganglion cell	5 studies	29% ± 12%	Explore
amacrine cell	5 studies	37% ± 11%	Explore
cardiac muscle cell	5 studies	22% ± 4%	Explore
retinal rod cell	5 studies	37% ± 14%	Explore
endothelial cell of lymphatic vessel	5 studies	23% ± 4%	Explore
monocyte	5 studies	27% ± 6%	Explore
pericyte	5 studies	22% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	19% ± 5%	Explore
CD4-positive, alpha-beta T cell	4 studies	19% ± 1%	Explore
non-classical monocyte	4 studies	23% ± 6%	Explore
granule cell	4 studies	34% ± 7%	Explore
naive B cell	4 studies	17% ± 1%	Explore
retinal pigment epithelial cell	4 studies	30% ± 9%	Explore
mast cell	4 studies	20% ± 3%	Explore
lymphocyte	4 studies	31% ± 8%	Explore
retinal cone cell	4 studies	31% ± 9%	Explore
club cell	4 studies	22% ± 8%	Explore
smooth muscle cell	4 studies	20% ± 2%	Explore
basal cell	4 studies	32% ± 13%	Explore
GABAergic interneuron	3 studies	35% ± 4%	Explore
glial cell	3 studies	23% ± 5%	Explore
plasma cell	3 studies	29% ± 10%	Explore
immature B cell	3 studies	17% ± 2%	Explore
mesothelial cell	3 studies	25% ± 6%	Explore
mononuclear phagocyte	3 studies	21% ± 2%	Explore
retinal bipolar neuron	3 studies	27% ± 5%	Explore
GABAergic amacrine cell	3 studies	42% ± 10%	Explore
glycinergic amacrine cell	3 studies	33% ± 2%	Explore
abnormal cell	3 studies	24% ± 8%	Explore
connective tissue cell	3 studies	18% ± 2%	Explore
ependymal cell	3 studies	29% ± 10%	Explore
leukocyte	3 studies	24% ± 7%	Explore
alveolar macrophage	3 studies	30% ± 8%	Explore
goblet cell	3 studies	32% ± 21%	Explore
plasmacytoid dendritic cell	3 studies	19% ± 3%	Explore
regulatory T cell	3 studies	17% ± 2%	Explore
gamma-delta T cell	3 studies	23% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	39% ± 20%	Explore
lung	7 studies	22% ± 5%	Explore
eye	7 studies	34% ± 12%	Explore
heart	4 studies	20% ± 1%	Explore
peripheral blood	3 studies	21% ± 2%	Explore
intestine	3 studies	19% ± 4%	Explore
liver	3 studies	33% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	1759.44	359 / 359	100%	41.91	286 / 286
brain	100%	2611.35	2641 / 2642	100%	44.65	705 / 705
lung	100%	1974.96	577 / 578	100%	32.02	1155 / 1155
prostate	100%	2104.13	245 / 245	100%	52.82	501 / 502
kidney	100%	3385.16	89 / 89	100%	39.35	897 / 901
breast	100%	2355.12	459 / 459	100%	48.18	1113 / 1118
thymus	100%	2848.44	653 / 653	100%	53.90	602 / 605
esophagus	100%	1769.73	1445 / 1445	99%	33.01	182 / 183
pancreas	100%	1299.51	328 / 328	99%	33.81	177 / 178
bladder	100%	1955.62	21 / 21	99%	36.83	501 / 504
ovary	100%	2063.76	180 / 180	99%	28.99	427 / 430
intestine	100%	2266.62	966 / 966	99%	47.49	523 / 527
uterus	100%	2318.72	170 / 170	99%	35.78	453 / 459
adrenal gland	100%	3487.12	258 / 258	98%	40.78	226 / 230
liver	100%	1345.61	226 / 226	95%	19.88	387 / 406
skin	100%	2040.16	1807 / 1809	93%	32.20	438 / 472
adipose	100%	2072.10	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	34.96	29 / 29
muscle	100%	2844.28	803 / 803	0%	0	0 / 0
spleen	100%	2225.53	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	28.84	45 / 45
ureter	0%	0	0 / 0	100%	20.40	1 / 1
blood vessel	100%	1907.19	1332 / 1335	0%	0	0 / 0
heart	97%	2691.42	839 / 861	0%	0	0 / 0
peripheral blood	87%	1391.89	807 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	73%	17.48	58 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006851	Biological process	mitochondrial calcium ion transmembrane transport
GO_0036444	Biological process	calcium import into the mitochondrion
GO_0051560	Biological process	mitochondrial calcium ion homeostasis
GO_0051562	Biological process	negative regulation of mitochondrial calcium ion concentration
GO_0051561	Biological process	positive regulation of mitochondrial calcium ion concentration
GO_0005758	Cellular component	mitochondrial intermembrane space
GO_0034704	Cellular component	calcium channel complex
GO_1990246	Cellular component	uniplex complex
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0046982	Molecular function	protein heterodimerization activity
GO_0061891	Molecular function	calcium ion sensor activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MICU2
Protein name	Mitochondrial calcium uptake 2 Calcium uptake protein 2, mitochondrial (EF-hand domain-containing family member A1)
Synonyms	EFHA1
Description	FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low . MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium . MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering . .
Accessions	A0A0A0MTD5 Q8IYU8 ENST00000468222.2 ENST00000382374.9

MICU2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review