MARK3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	39% ± 16%	Explore
fibroblast	20 studies	33% ± 15%	Explore
astrocyte	18 studies	50% ± 19%	Explore
oligodendrocyte	15 studies	42% ± 17%	Explore
oligodendrocyte precursor cell	14 studies	44% ± 19%	Explore
microglial cell	14 studies	43% ± 14%	Explore
macrophage	13 studies	39% ± 16%	Explore
ciliated cell	12 studies	29% ± 13%	Explore
glutamatergic neuron	12 studies	53% ± 25%	Explore
pericyte	12 studies	36% ± 17%	Explore
B cell	11 studies	25% ± 7%	Explore
GABAergic neuron	11 studies	49% ± 23%	Explore
classical monocyte	10 studies	23% ± 10%	Explore
smooth muscle cell	10 studies	34% ± 10%	Explore
T cell	9 studies	27% ± 9%	Explore
natural killer cell	9 studies	25% ± 7%	Explore
type I pneumocyte	9 studies	43% ± 14%	Explore
epithelial cell	9 studies	43% ± 23%	Explore
myeloid cell	9 studies	32% ± 11%	Explore
basal cell	9 studies	36% ± 22%	Explore
adipocyte	9 studies	43% ± 11%	Explore
CD4-positive, alpha-beta T cell	8 studies	22% ± 5%	Explore
mast cell	8 studies	28% ± 9%	Explore
mesothelial cell	8 studies	41% ± 12%	Explore
endothelial cell of lymphatic vessel	8 studies	36% ± 14%	Explore
type II pneumocyte	7 studies	45% ± 16%	Explore
amacrine cell	7 studies	33% ± 10%	Explore
CD8-positive, alpha-beta T cell	6 studies	25% ± 5%	Explore
neuron	6 studies	51% ± 15%	Explore
interneuron	6 studies	61% ± 20%	Explore
retinal ganglion cell	6 studies	41% ± 12%	Explore
retina horizontal cell	6 studies	32% ± 9%	Explore
retinal cone cell	6 studies	36% ± 7%	Explore
dendritic cell	6 studies	37% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	18% ± 2%	Explore
regulatory T cell	6 studies	19% ± 4%	Explore
monocyte	6 studies	36% ± 11%	Explore
retinal bipolar neuron	5 studies	26% ± 6%	Explore
myofibroblast cell	5 studies	30% ± 16%	Explore
retinal rod cell	5 studies	33% ± 10%	Explore
cardiac muscle cell	5 studies	60% ± 15%	Explore
respiratory goblet cell	5 studies	34% ± 15%	Explore
goblet cell	5 studies	33% ± 27%	Explore
club cell	5 studies	37% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	23% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	27% ± 3%	Explore
mature NK T cell	4 studies	22% ± 8%	Explore
non-classical monocyte	4 studies	30% ± 11%	Explore
granule cell	4 studies	46% ± 6%	Explore
plasma cell	4 studies	40% ± 5%	Explore
retinal pigment epithelial cell	4 studies	38% ± 25%	Explore
capillary endothelial cell	4 studies	25% ± 7%	Explore
endothelial cell of artery	4 studies	24% ± 8%	Explore
vein endothelial cell	4 studies	35% ± 20%	Explore
lymphocyte	4 studies	41% ± 14%	Explore
Mueller cell	4 studies	36% ± 8%	Explore
OFF-bipolar cell	4 studies	29% ± 8%	Explore
ON-bipolar cell	4 studies	29% ± 8%	Explore
muscle cell	4 studies	35% ± 24%	Explore
erythrocyte	4 studies	50% ± 21%	Explore
leukocyte	4 studies	41% ± 16%	Explore
conventional dendritic cell	3 studies	30% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
GABAergic interneuron	3 studies	48% ± 3%	Explore
glial cell	3 studies	34% ± 6%	Explore
progenitor cell	3 studies	32% ± 4%	Explore
squamous epithelial cell	3 studies	42% ± 20%	Explore
mononuclear phagocyte	3 studies	36% ± 5%	Explore
mucosal invariant T cell	3 studies	23% ± 6%	Explore
GABAergic amacrine cell	3 studies	42% ± 7%	Explore
glycinergic amacrine cell	3 studies	35% ± 3%	Explore
rod bipolar cell	3 studies	30% ± 9%	Explore
secretory cell	3 studies	19% ± 3%	Explore
endothelial cell of vascular tree	3 studies	44% ± 19%	Explore
hepatocyte	3 studies	48% ± 22%	Explore
abnormal cell	3 studies	35% ± 13%	Explore
connective tissue cell	3 studies	31% ± 7%	Explore
ependymal cell	3 studies	55% ± 17%	Explore
adventitial cell	3 studies	27% ± 12%	Explore
alveolar macrophage	3 studies	47% ± 8%	Explore
chondrocyte	3 studies	34% ± 14%	Explore
transit amplifying cell	3 studies	42% ± 37%	Explore
naive B cell	3 studies	16% ± 1%	Explore
mural cell	3 studies	42% ± 16%	Explore
mucus secreting cell	3 studies	38% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	49% ± 21%	Explore
lung	9 studies	32% ± 12%	Explore
eye	7 studies	37% ± 18%	Explore
heart	5 studies	41% ± 14%	Explore
liver	4 studies	36% ± 16%	Explore
peripheral blood	3 studies	30% ± 2%	Explore
intestine	3 studies	23% ± 7%	Explore
adipose	3 studies	41% ± 9%	Explore
kidney	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4680.76	21 / 21	100%	11.69	504 / 504
breast	100%	4146.14	459 / 459	100%	11.47	1118 / 1118
esophagus	100%	4759.60	1445 / 1445	100%	14.29	183 / 183
intestine	100%	4554.59	966 / 966	100%	9.03	527 / 527
lung	100%	5814.28	578 / 578	100%	12.12	1155 / 1155
pancreas	100%	3669.87	328 / 328	100%	11.19	178 / 178
prostate	100%	4938.56	245 / 245	100%	9.50	502 / 502
stomach	100%	4836.70	359 / 359	100%	8.73	286 / 286
uterus	100%	5001.33	170 / 170	100%	13.19	459 / 459
brain	100%	4775.56	2638 / 2642	100%	14.15	705 / 705
thymus	100%	5655.03	653 / 653	100%	11.28	604 / 605
ovary	100%	5365.02	180 / 180	100%	9.55	429 / 430
adrenal gland	100%	6642.54	258 / 258	100%	8.68	229 / 230
kidney	100%	4283.16	89 / 89	99%	8.20	895 / 901
skin	100%	4008.22	1809 / 1809	98%	10.89	463 / 472
liver	100%	2249.43	226 / 226	97%	4.91	393 / 406
adipose	100%	4508.55	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	10.86	29 / 29
muscle	100%	5099.67	803 / 803	0%	0	0 / 0
spleen	100%	5828.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	11.97	45 / 45
ureter	0%	0	0 / 0	100%	9.81	1 / 1
blood vessel	100%	3783.71	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	4741.04	928 / 929	0%	0	0 / 0
heart	99%	4980.54	855 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	6.81	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032092	Biological process	positive regulation of protein binding
GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_1900181	Biological process	negative regulation of protein localization to nucleus
GO_0036289	Biological process	peptidyl-serine autophosphorylation
GO_0035556	Biological process	intracellular signal transduction
GO_0006468	Biological process	protein phosphorylation
GO_0035331	Biological process	negative regulation of hippo signaling
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0030425	Cellular component	dendrite
GO_0050321	Molecular function	tau-protein kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0005515	Molecular function	protein binding
GO_0005524	Molecular function	ATP binding
GO_0048156	Molecular function	tau protein binding

IV. Literature review

[source]

Gene name	MARK3
Protein name	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) non-specific serine/threonine protein kinase (EC 2.7.11.1) MAP/microtubule affinity-regulating kinase 3 Microtubule affinity regulating kinase 3
Synonyms	EMK2 hCG_25498 CTAK1
Description	FUNCTION: Serine/threonine-protein kinase . Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU . Phosphorylates CDC25C on 'Ser-216' . Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus . Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol . Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 . Phosphorylates PKP2 and KSR1 . .
Accessions	ENST00000678343.1 ENST00000676938.1 A0A7I2V2N8 ENST00000676645.1 ENST00000677348.1 ENST00000677035.1 A0A7I2YQF7 A0A7I2V4T5 A0A7I2V2I9 A0A7I2V3B9 ENST00000679105.1 A0A7I2V3P5 ENST00000677432.1 ENST00000676564.1 A0A7I2V2J6 ENST00000677942.1 A0A7I2YQJ7 ENST00000429436.7 [P27448-5] ENST00000677347.1 ENST00000678619.1 ENST00000677604.1 ENST00000678022.1 H0YNV4 ENST00000678237.1 ENST00000677118.1 ENST00000440884.7 [P27448-8] ENST00000678169.1 A0A7I2V602 ENST00000677360.1 ENST00000677829.1 ENST00000676905.1 A0A7I2V2U9 ENST00000677857.1 ENST00000677560.1 ENST00000679330.1 H0YJI9 ENST00000677404.1 A0A7I2YQ84 A2SY06 ENST00000677133.1 H0YKP9 ENST00000553942.5 [P27448-4] ENST00000677051.1 ENST00000676518.1 ENST00000678423.1 A0A7I2V4L1 A0A7I2V409 ENST00000303622.13 [P27448-3] A0A7I2V4G7 A0A7I2YQ91 ENST00000678179.1 ENST00000678175.1 ENST00000676694.1 A0A7I2V4K8 ENST00000335102.9 ENST00000678999.1 A0A7I2YQF4 ENST00000216288.11 [P27448-6] A0A7I2V3I9 ENST00000678278.1 ENST00000676830.1 ENST00000678897.1 ENST00000677104.1 A0A7I2V3Q1 A0A7I2V3K2 A0A7I2V5G3 H0YIY6 J3KNR0 ENST00000556744.2 ENST00000560417.6 A0A7I2V3X7 ENST00000677228.1 ENST00000416682.6 [P27448-2] A0A7I2V5Z7 A0A7I2V3C6 P27448 ENST00000678302.1 A0A7I2V2E3 A0A7I2V5H7 A0A7I2V4T2 ENST00000676897.1 A0A7I2V483 ENST00000676838.1 ENST00000677869.1 ENST00000554627.5 ENST00000678207.1 A0A7I2V549 A0A7I2V639 ENST00000561314.6

MARK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review