LDLRAD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030336Biological processnegative regulation of cell migration
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0060392Biological processnegative regulation of SMAD protein signal transduction
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031901Cellular componentearly endosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0070412Molecular functionR-SMAD binding

IV. Literature review

[source]
Gene nameLDLRAD4
Protein nameChromosome 18 open reading frame 1, isoform CRA_a (Low density lipoprotein receptor class A domain containing 4)
Low density lipoprotein receptor class A domain containing 4
Low-density lipoprotein receptor class A domain-containing protein 4
SynonymshCG_37193
C18orf1
DescriptionFUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. .

AccessionsENST00000359446.11 [O15165-1]
ENST00000587757.5 [O15165-6]
ENST00000676891.1
ENST00000677055.1
A0A7I2V2E6
ENST00000678556.1
A0A7I2V2Z9
ENST00000586765.1 [O15165-7]
K7EMG1
ENST00000676672.1
ENST00000678309.1
ENST00000585931.5 [O15165-5]
ENST00000676773.1
K7EJM9
ENST00000679177.1
A0A7I2YQI3
A0A7I2V3W1
ENST00000679167.1
ENST00000679091.1 [O15165-1]
A0A7I2V3Q9
A0A7I2V575
ENST00000586222.2
ENST00000677744.1 [O15165-5]
ENST00000677304.1
ENST00000399848.7 [O15165-2]
ENST00000677910.1 [O15165-5]
ENST00000678400.1
A0A7I2V3Z2
ENST00000593236.1
ENST00000590308.1
ENST00000587905.6
O15165