Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 48% ± 15% | |
astrocyte | 19 studies | 43% ± 18% | |
macrophage | 18 studies | 49% ± 26% | |
plasmacytoid dendritic cell | 17 studies | 44% ± 18% | |
oligodendrocyte | 16 studies | 36% ± 16% | |
regulatory T cell | 16 studies | 29% ± 15% | |
microglial cell | 15 studies | 76% ± 16% | |
oligodendrocyte precursor cell | 14 studies | 50% ± 17% | |
B cell | 12 studies | 24% ± 9% | |
glutamatergic neuron | 12 studies | 63% ± 18% | |
GABAergic neuron | 11 studies | 54% ± 19% | |
fibroblast | 11 studies | 32% ± 12% | |
T cell | 11 studies | 32% ± 12% | |
smooth muscle cell | 10 studies | 35% ± 13% | |
dendritic cell | 9 studies | 51% ± 19% | |
conventional dendritic cell | 9 studies | 24% ± 8% | |
myeloid cell | 9 studies | 47% ± 24% | |
CD8-positive, alpha-beta T cell | 9 studies | 24% ± 6% | |
endothelial cell of lymphatic vessel | 8 studies | 37% ± 11% | |
CD8-positive, alpha-beta memory T cell | 7 studies | 26% ± 8% | |
retinal cone cell | 7 studies | 61% ± 33% | |
CD4-positive, alpha-beta T cell | 7 studies | 29% ± 12% | |
adipocyte | 7 studies | 33% ± 13% | |
mast cell | 7 studies | 29% ± 14% | |
ciliated cell | 7 studies | 43% ± 25% | |
natural killer cell | 7 studies | 26% ± 7% | |
neuron | 6 studies | 42% ± 14% | |
gamma-delta T cell | 6 studies | 36% ± 9% | |
memory B cell | 6 studies | 22% ± 6% | |
interneuron | 6 studies | 61% ± 17% | |
precursor B cell | 6 studies | 39% ± 14% | |
pro-B cell | 5 studies | 30% ± 7% | |
cardiac muscle cell | 5 studies | 53% ± 15% | |
monocyte | 5 studies | 46% ± 17% | |
leukocyte | 5 studies | 45% ± 26% | |
naive B cell | 4 studies | 20% ± 4% | |
hepatocyte | 4 studies | 69% ± 26% | |
granule cell | 4 studies | 64% ± 15% | |
mononuclear phagocyte | 4 studies | 34% ± 16% | |
vein endothelial cell | 4 studies | 40% ± 21% | |
epithelial cell | 4 studies | 38% ± 31% | |
lymphocyte | 4 studies | 36% ± 10% | |
retinal rod cell | 4 studies | 63% ± 18% | |
endothelial cell of vascular tree | 4 studies | 46% ± 17% | |
innate lymphoid cell | 4 studies | 27% ± 7% | |
mesothelial cell | 4 studies | 38% ± 12% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 21% ± 3% | |
cholangiocyte | 3 studies | 20% ± 2% | |
hepatic stellate cell | 3 studies | 46% ± 18% | |
GABAergic interneuron | 3 studies | 52% ± 18% | |
myofibroblast cell | 3 studies | 43% ± 16% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 30% ± 7% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 25% ± 4% | |
endothelial cell of artery | 3 studies | 26% ± 8% | |
amacrine cell | 3 studies | 41% ± 23% | |
glycinergic amacrine cell | 3 studies | 32% ± 0% | |
chondrocyte | 3 studies | 33% ± 14% | |
T follicular helper cell | 3 studies | 21% ± 3% | |
ependymal cell | 3 studies | 69% ± 8% | |
alveolar macrophage | 3 studies | 47% ± 10% | |
club cell | 3 studies | 32% ± 14% | |
respiratory goblet cell | 3 studies | 41% ± 20% | |
group 3 innate lymphoid cell | 3 studies | 28% ± 4% | |
mucus secreting cell | 3 studies | 35% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 4677.10 | 2642 / 2642 | 100% | 7.98 | 702 / 705 |
breast | 99% | 1988.75 | 454 / 459 | 98% | 10.19 | 1098 / 1118 |
prostate | 100% | 2919.53 | 245 / 245 | 93% | 4.67 | 466 / 502 |
thymus | 99% | 1160.92 | 646 / 653 | 88% | 4.00 | 530 / 605 |
adrenal gland | 98% | 1360.13 | 253 / 258 | 76% | 2.87 | 174 / 230 |
intestine | 100% | 1675.24 | 964 / 966 | 71% | 1.57 | 374 / 527 |
liver | 92% | 1016.96 | 208 / 226 | 67% | 1.53 | 270 / 406 |
lung | 94% | 1032.30 | 546 / 578 | 57% | 1.56 | 658 / 1155 |
uterus | 99% | 3018.93 | 168 / 170 | 49% | 1.18 | 226 / 459 |
bladder | 100% | 1302.81 | 21 / 21 | 44% | 1.11 | 223 / 504 |
stomach | 65% | 802.23 | 232 / 359 | 73% | 1.88 | 208 / 286 |
esophagus | 69% | 1437.51 | 999 / 1445 | 66% | 1.85 | 120 / 183 |
kidney | 69% | 700.07 | 61 / 89 | 65% | 2.95 | 589 / 901 |
pancreas | 18% | 120.42 | 60 / 328 | 85% | 2.77 | 151 / 178 |
skin | 56% | 568.89 | 1008 / 1809 | 46% | 1.24 | 218 / 472 |
spleen | 100% | 1225.43 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3653.29 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 97% | 1397.22 | 1172 / 1204 | 0% | 0 | 0 / 0 |
heart | 95% | 2086.71 | 818 / 861 | 0% | 0 | 0 / 0 |
ovary | 32% | 358.24 | 57 / 180 | 59% | 1.26 | 255 / 430 |
eye | 0% | 0 | 0 / 0 | 78% | 2.19 | 62 / 80 |
lymph node | 0% | 0 | 0 / 0 | 72% | 2.31 | 21 / 29 |
muscle | 58% | 525.12 | 465 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 49% | 1.12 | 22 / 45 |
peripheral blood | 48% | 882.23 | 450 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_0010719 | Biological process | negative regulation of epithelial to mesenchymal transition |
GO_0060392 | Biological process | negative regulation of SMAD protein signal transduction |
GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0031901 | Cellular component | early endosome membrane |
GO_0000139 | Cellular component | Golgi membrane |
GO_0016020 | Cellular component | membrane |
GO_0070412 | Molecular function | R-SMAD binding |
Gene name | LDLRAD4 |
Protein name | Chromosome 18 open reading frame 1, isoform CRA_a (Low density lipoprotein receptor class A domain containing 4) Low density lipoprotein receptor class A domain containing 4 Low-density lipoprotein receptor class A domain-containing protein 4 |
Synonyms | hCG_37193 C18orf1 |
Description | FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. . |
Accessions | ENST00000359446.11 [O15165-1] ENST00000587757.5 [O15165-6] ENST00000676891.1 ENST00000677055.1 A0A7I2V2E6 ENST00000678556.1 A0A7I2V2Z9 ENST00000586765.1 [O15165-7] K7EMG1 ENST00000676672.1 ENST00000678309.1 ENST00000585931.5 [O15165-5] ENST00000676773.1 K7EJM9 ENST00000679177.1 A0A7I2YQI3 A0A7I2V3W1 ENST00000679167.1 ENST00000679091.1 [O15165-1] A0A7I2V3Q9 A0A7I2V575 ENST00000586222.2 ENST00000677744.1 [O15165-5] ENST00000677304.1 ENST00000399848.7 [O15165-2] ENST00000677910.1 [O15165-5] ENST00000678400.1 A0A7I2V3Z2 ENST00000593236.1 ENST00000590308.1 ENST00000587905.6 O15165 |