KDM6B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0021766Biological processhippocampus development
GO_0045446Biological processendothelial cell differentiation
GO_0007507Biological processheart development
GO_0055007Biological processcardiac muscle cell differentiation
GO_0014823Biological processresponse to activity
GO_0048333Biological processmesodermal cell differentiation
GO_0006338Biological processchromatin remodeling
GO_0002437Biological processinflammatory response to antigenic stimulus
GO_0045165Biological processcell fate commitment
GO_0060992Biological processresponse to fungicide
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0044666Cellular componentMLL3/4 complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0008013Molecular functionbeta-catenin binding
GO_0032452Molecular functionhistone demethylase activity
GO_0046872Molecular functionmetal ion binding
GO_0031490Molecular functionchromatin DNA binding
GO_0071558Molecular functionhistone H3K27me2/H3K27me3 demethylase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKDM6B
Protein name[histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68)
Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B)
SynonymsJMJD3
KIAA0346
DescriptionFUNCTION: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code . Demethylates trimethylated and dimethylated H3 'Lys-27' . Plays a central role in regulation of posterior development, by regulating HOX gene expression . Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). .

AccessionsO15054
ENST00000448097.7 [O15054-2]
ENST00000570632.1
ENST00000254846.9 [O15054-1]
I3L0Z0