KDM4C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_2000736Biological processregulation of stem cell differentiation
GO_0006338Biological processchromatin remodeling
GO_0019827Biological processstem cell population maintenance
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0030521Biological processandrogen receptor signaling pathway
GO_0001825Biological processblastocyst formation
GO_0005654Cellular componentnucleoplasm
GO_0005721Cellular componentpericentric heterochromatin
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0032454Molecular functionhistone H3K9 demethylase activity
GO_0062072Molecular functionH3K9me3 modified histone binding
GO_0032452Molecular functionhistone demethylase activity
GO_0008270Molecular functionzinc ion binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0140684Molecular functionhistone H3K9me2/H3K9me3 demethylase activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0051864Molecular functionhistone H3K36 demethylase activity

IV. Literature review

[source]
Gene nameKDM4C
Protein nameLysine demethylase 4C
Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C)
SynonymsGASC1
JMJD2C
JHDM3C
KIAA0780
DescriptionFUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. .

AccessionsENST00000381309.8 [Q9H3R0-1]
B0QZ60
A0A0A0MSR6
ENST00000420847.2
ENST00000543771.5 [Q9H3R0-3]
ENST00000381306.7 [Q9H3R0-2]
ENST00000428870.6
F8WCN1
C9J879
ENST00000438023.5
Q9H3R0
ENST00000536108.5 [Q9H3R0-4]
ENST00000401787.7