Name | Number of supported studies | Average coverage | |
---|---|---|---|
mast cell | 11 studies | 38% ± 15% | |
microglial cell | 7 studies | 40% ± 16% | |
macrophage | 7 studies | 38% ± 17% | |
endothelial cell | 6 studies | 22% ± 7% | |
type II pneumocyte | 6 studies | 24% ± 8% | |
glutamatergic neuron | 5 studies | 38% ± 17% | |
epithelial cell | 5 studies | 27% ± 16% | |
cardiac muscle cell | 5 studies | 31% ± 8% | |
dendritic cell | 5 studies | 27% ± 9% | |
brush cell | 4 studies | 30% ± 13% | |
club cell | 4 studies | 26% ± 9% | |
monocyte | 4 studies | 27% ± 11% | |
type I pneumocyte | 4 studies | 20% ± 5% | |
oligodendrocyte | 4 studies | 35% ± 17% | |
myeloid cell | 3 studies | 25% ± 4% | |
adipocyte | 3 studies | 28% ± 5% | |
intestinal crypt stem cell | 3 studies | 25% ± 6% | |
fibroblast | 3 studies | 20% ± 2% | |
respiratory goblet cell | 3 studies | 31% ± 14% | |
GABAergic neuron | 3 studies | 50% ± 20% | |
interneuron | 3 studies | 63% ± 10% | |
neuron | 3 studies | 51% ± 16% | |
renal principal cell | 3 studies | 39% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 7515.70 | 653 / 653 | 94% | 79.01 | 567 / 605 |
pancreas | 100% | 4807.88 | 328 / 328 | 87% | 33.12 | 155 / 178 |
prostate | 88% | 878.77 | 215 / 245 | 88% | 17.57 | 444 / 502 |
stomach | 80% | 9523.54 | 287 / 359 | 89% | 78.97 | 255 / 286 |
lung | 98% | 1595.61 | 564 / 578 | 67% | 21.61 | 770 / 1155 |
kidney | 100% | 3157.69 | 89 / 89 | 62% | 19.01 | 556 / 901 |
adrenal gland | 100% | 25207.82 | 258 / 258 | 52% | 22.58 | 119 / 230 |
intestine | 56% | 1256.36 | 541 / 966 | 94% | 88.03 | 494 / 527 |
bladder | 48% | 939.38 | 10 / 21 | 65% | 35.83 | 327 / 504 |
heart | 96% | 2318.47 | 828 / 861 | 0% | 0 | 0 / 0 |
spleen | 95% | 914.56 | 230 / 241 | 0% | 0 | 0 / 0 |
breast | 59% | 362.32 | 270 / 459 | 35% | 5.24 | 392 / 1118 |
peripheral blood | 77% | 1273.31 | 716 / 929 | 0% | 0 | 0 / 0 |
adipose | 72% | 466.51 | 863 / 1204 | 0% | 0 | 0 / 0 |
uterus | 26% | 144.49 | 45 / 170 | 43% | 11.42 | 196 / 459 |
esophagus | 11% | 58.14 | 158 / 1445 | 53% | 26.19 | 97 / 183 |
ovary | 10% | 48.81 | 18 / 180 | 48% | 9.54 | 207 / 430 |
eye | 0% | 0 | 0 / 0 | 54% | 5.98 | 43 / 80 |
brain | 3% | 15.84 | 77 / 2642 | 40% | 5.01 | 283 / 705 |
tonsil | 0% | 0 | 0 / 0 | 31% | 7.28 | 14 / 45 |
blood vessel | 20% | 119.88 | 271 / 1335 | 0% | 0 | 0 / 0 |
liver | 2% | 12.05 | 5 / 226 | 17% | 6.58 | 68 / 406 |
skin | 2% | 11.06 | 45 / 1809 | 7% | 1.07 | 33 / 472 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.61 | 2 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007622 | Biological process | rhythmic behavior |
GO_0086011 | Biological process | membrane repolarization during action potential |
GO_0098915 | Biological process | membrane repolarization during ventricular cardiac muscle cell action potential |
GO_0071872 | Biological process | cellular response to epinephrine stimulus |
GO_0060048 | Biological process | cardiac muscle contraction |
GO_0071805 | Biological process | potassium ion transmembrane transport |
GO_0070293 | Biological process | renal absorption |
GO_0071320 | Biological process | cellular response to cAMP |
GO_0090102 | Biological process | cochlea development |
GO_0050910 | Biological process | detection of mechanical stimulus involved in sensory perception of sound |
GO_0035176 | Biological process | social behavior |
GO_0071875 | Biological process | adrenergic receptor signaling pathway |
GO_0006006 | Biological process | glucose metabolic process |
GO_1990573 | Biological process | potassium ion import across plasma membrane |
GO_1901381 | Biological process | positive regulation of potassium ion transmembrane transport |
GO_0070294 | Biological process | renal sodium ion absorption |
GO_0071466 | Biological process | cellular response to xenobiotic stimulus |
GO_0098914 | Biological process | membrane repolarization during atrial cardiac muscle cell action potential |
GO_0008217 | Biological process | regulation of blood pressure |
GO_0086005 | Biological process | ventricular cardiac muscle cell action potential |
GO_0086013 | Biological process | membrane repolarization during cardiac muscle cell action potential |
GO_0086014 | Biological process | atrial cardiac muscle cell action potential |
GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
GO_0030644 | Biological process | intracellular chloride ion homeostasis |
GO_0060117 | Biological process | auditory receptor cell development |
GO_0042472 | Biological process | inner ear morphogenesis |
GO_0008016 | Biological process | regulation of heart contraction |
GO_0010460 | Biological process | positive regulation of heart rate |
GO_0007605 | Biological process | sensory perception of sound |
GO_0060307 | Biological process | regulation of ventricular cardiac muscle cell membrane repolarization |
GO_0015705 | Biological process | iodide transport |
GO_0060453 | Biological process | regulation of gastric acid secretion |
GO_0097623 | Biological process | potassium ion export across plasma membrane |
GO_0050892 | Biological process | intestinal absorption |
GO_0035934 | Biological process | corticosterone secretion |
GO_0062094 | Biological process | stomach development |
GO_1905515 | Biological process | non-motile cilium assembly |
GO_0060372 | Biological process | regulation of atrial cardiac muscle cell membrane repolarization |
GO_0007507 | Biological process | heart development |
GO_0032868 | Biological process | response to insulin |
GO_0048839 | Biological process | inner ear development |
GO_0086003 | Biological process | cardiac muscle cell contraction |
GO_0055075 | Biological process | potassium ion homeostasis |
GO_0060306 | Biological process | regulation of membrane repolarization |
GO_0030218 | Biological process | erythrocyte differentiation |
GO_0001698 | Biological process | gastrin-induced gastric acid secretion |
GO_0001508 | Biological process | action potential |
GO_0060452 | Biological process | positive regulation of cardiac muscle contraction |
GO_0045121 | Cellular component | membrane raft |
GO_0043025 | Cellular component | neuronal cell body |
GO_0043005 | Cellular component | neuron projection |
GO_0008076 | Cellular component | voltage-gated potassium channel complex |
GO_0016323 | Cellular component | basolateral plasma membrane |
GO_0034702 | Cellular component | monoatomic ion channel complex |
GO_1990794 | Cellular component | basolateral part of cell |
GO_0005770 | Cellular component | late endosome |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005769 | Cellular component | early endosome |
GO_0005764 | Cellular component | lysosome |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005737 | Cellular component | cytoplasm |
GO_0097546 | Cellular component | ciliary base |
GO_0098576 | Cellular component | lumenal side of membrane |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0030133 | Cellular component | transport vesicle |
GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
GO_0005249 | Molecular function | voltage-gated potassium channel activity |
GO_0097110 | Molecular function | scaffold protein binding |
GO_0034236 | Molecular function | protein kinase A catalytic subunit binding |
GO_1902282 | Molecular function | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005251 | Molecular function | delayed rectifier potassium channel activity |
GO_0034237 | Molecular function | protein kinase A regulatory subunit binding |
GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
GO_0086008 | Molecular function | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization |
GO_0044325 | Molecular function | transmembrane transporter binding |
GO_0005515 | Molecular function | protein binding |
GO_0015271 | Molecular function | outward rectifier potassium channel activity |
GO_0086089 | Molecular function | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization |
GO_0008157 | Molecular function | protein phosphatase 1 binding |
Gene name | KCNQ1 |
Protein name | IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) Potassium voltage-gated channel isoform 2 Potassium voltage-gated channel isoform 1 Potassium voltage-gated channel subfamily Q member 1 |
Synonyms | KCNA8 KVLQT1 KCNA9 |
Description | FUNCTION: Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon . Associates with KCNE beta subunits that modulates current kinetics . Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current . Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) . Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current . When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions . This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current . When associated with KCNE4, inhibits voltage-gated potassium channel activity . When associated with KCNE5, this complex only conducts current upon strong and continued depolarization . Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity . Binds with phosphatidylinositol 4,5-bisphosphate . KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability. .; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. . |
Accessions | P51787 ENST00000155840.12 [P51787-1] ENST00000335475.6 [P51787-2] A0A0J9YXF5 A0A2R8YEQ9 ENST00000632153.1 ENST00000526095.2 ENST00000632981.1 A0FIK7 A0FIK8 A0A2R8YDV1 E9PPZ0 ENST00000646564.2 ENST00000496887.7 |