KCNQ1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007622Biological processrhythmic behavior
GO_0086011Biological processmembrane repolarization during action potential
GO_0098915Biological processmembrane repolarization during ventricular cardiac muscle cell action potential
GO_0071872Biological processcellular response to epinephrine stimulus
GO_0060048Biological processcardiac muscle contraction
GO_0071805Biological processpotassium ion transmembrane transport
GO_0070293Biological processrenal absorption
GO_0071320Biological processcellular response to cAMP
GO_0090102Biological processcochlea development
GO_0050910Biological processdetection of mechanical stimulus involved in sensory perception of sound
GO_0035176Biological processsocial behavior
GO_0071875Biological processadrenergic receptor signaling pathway
GO_0006006Biological processglucose metabolic process
GO_1990573Biological processpotassium ion import across plasma membrane
GO_1901381Biological processpositive regulation of potassium ion transmembrane transport
GO_0070294Biological processrenal sodium ion absorption
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0098914Biological processmembrane repolarization during atrial cardiac muscle cell action potential
GO_0008217Biological processregulation of blood pressure
GO_0086005Biological processventricular cardiac muscle cell action potential
GO_0086013Biological processmembrane repolarization during cardiac muscle cell action potential
GO_0086014Biological processatrial cardiac muscle cell action potential
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0030644Biological processintracellular chloride ion homeostasis
GO_0060117Biological processauditory receptor cell development
GO_0042472Biological processinner ear morphogenesis
GO_0008016Biological processregulation of heart contraction
GO_0010460Biological processpositive regulation of heart rate
GO_0007605Biological processsensory perception of sound
GO_0060307Biological processregulation of ventricular cardiac muscle cell membrane repolarization
GO_0015705Biological processiodide transport
GO_0060453Biological processregulation of gastric acid secretion
GO_0097623Biological processpotassium ion export across plasma membrane
GO_0050892Biological processintestinal absorption
GO_0035934Biological processcorticosterone secretion
GO_0062094Biological processstomach development
GO_1905515Biological processnon-motile cilium assembly
GO_0060372Biological processregulation of atrial cardiac muscle cell membrane repolarization
GO_0007507Biological processheart development
GO_0032868Biological processresponse to insulin
GO_0048839Biological processinner ear development
GO_0086003Biological processcardiac muscle cell contraction
GO_0055075Biological processpotassium ion homeostasis
GO_0060306Biological processregulation of membrane repolarization
GO_0030218Biological processerythrocyte differentiation
GO_0001698Biological processgastrin-induced gastric acid secretion
GO_0001508Biological processaction potential
GO_0060452Biological processpositive regulation of cardiac muscle contraction
GO_0045121Cellular componentmembrane raft
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0016323Cellular componentbasolateral plasma membrane
GO_0034702Cellular componentmonoatomic ion channel complex
GO_1990794Cellular componentbasolateral part of cell
GO_0005770Cellular componentlate endosome
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0097546Cellular componentciliary base
GO_0098576Cellular componentlumenal side of membrane
GO_0016324Cellular componentapical plasma membrane
GO_0030133Cellular componenttransport vesicle
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0097110Molecular functionscaffold protein binding
GO_0034236Molecular functionprotein kinase A catalytic subunit binding
GO_1902282Molecular functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO_0005516Molecular functioncalmodulin binding
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_0034237Molecular functionprotein kinase A regulatory subunit binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0086008Molecular functionvoltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005515Molecular functionprotein binding
GO_0015271Molecular functionoutward rectifier potassium channel activity
GO_0086089Molecular functionvoltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO_0008157Molecular functionprotein phosphatase 1 binding

IV. Literature review

[source]
Gene nameKCNQ1
Protein nameIKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
Potassium voltage-gated channel isoform 2
Potassium voltage-gated channel isoform 1
Potassium voltage-gated channel subfamily Q member 1
SynonymsKCNA8
KVLQT1
KCNA9
DescriptionFUNCTION: Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon . Associates with KCNE beta subunits that modulates current kinetics . Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current . Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) . Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current . When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions . This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current . When associated with KCNE4, inhibits voltage-gated potassium channel activity . When associated with KCNE5, this complex only conducts current upon strong and continued depolarization . Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity . Binds with phosphatidylinositol 4,5-bisphosphate . KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability. .; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. .

AccessionsP51787
ENST00000155840.12 [P51787-1]
ENST00000335475.6 [P51787-2]
A0A0J9YXF5
A0A2R8YEQ9
ENST00000632153.1
ENST00000526095.2
ENST00000632981.1
A0FIK7
A0FIK8
A0A2R8YDV1
E9PPZ0
ENST00000646564.2
ENST00000496887.7