JMJD6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140694Biological processnon-membrane-bounded organelle assembly
GO_0051260Biological processprotein homooligomerization
GO_0032463Biological processnegative regulation of protein homooligomerization
GO_0048821Biological processerythrocyte development
GO_0042116Biological processmacrophage activation
GO_0030324Biological processlung development
GO_0006397Biological processmRNA processing
GO_0007507Biological processheart development
GO_0001822Biological processkidney development
GO_0060041Biological processretina development in camera-type eye
GO_0006338Biological processchromatin remodeling
GO_0002040Biological processsprouting angiogenesis
GO_0033077Biological processT cell differentiation in thymus
GO_0008380Biological processRNA splicing
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0048024Biological processregulation of mRNA splicing, via spliceosome
GO_0006909Biological processphagocytosis
GO_0035513Biological processoxidative RNA demethylation
GO_0043654Biological processrecognition of apoptotic cell
GO_0018395Biological processpeptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0038023Molecular functionsignaling receptor activity
GO_0070815Molecular functionpeptidyl-lysine 5-dioxygenase activity
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0033749Molecular functionhistone H4R3 demethylase activity
GO_0042802Molecular functionidentical protein binding
GO_0106140Molecular functionP-TEFb complex binding
GO_0035515Molecular functionoxidative RNA demethylase activity
GO_0032452Molecular functionhistone demethylase activity
GO_0005506Molecular functioniron ion binding
GO_0140537Molecular functiontranscription regulator activator activity
GO_0003723Molecular functionRNA binding
GO_0140457Molecular functionprotein demethylase activity
GO_0033746Molecular functionhistone H3R2 demethylase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameJMJD6
Protein nameBifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor)
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR)
SynonymsKIAA0585
hCG_30900
PTDSR
PSR
DescriptionFUNCTION: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase . Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 . Hydroxylates its own N-terminus, which is required for homooligomerization . Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA . Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation . Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code . However, histone arginine demethylation may not constitute the primary activity in vivo . In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation . Demethylates other arginine methylated-proteins such as ESR1 . Has no histone lysine demethylase activity . Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses . .

AccessionsQ6NYC1
ENST00000585429.1
ENST00000542934.5
ENST00000303996.10
A0A0S2PZM4
K7EJU9
B2WTI3
ENST00000445478.6 [Q6NYC1-3]
ENST00000617192.4
B2WTI4
ENST00000397625.9 [Q6NYC1-1]