IST1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	20 studies	25% ± 9%	Explore
macrophage	13 studies	23% ± 7%	Explore
fibroblast	12 studies	20% ± 5%	Explore
natural killer cell	10 studies	18% ± 3%	Explore
microglial cell	9 studies	22% ± 7%	Explore
ciliated cell	9 studies	30% ± 15%	Explore
epithelial cell	8 studies	36% ± 19%	Explore
regulatory T cell	8 studies	17% ± 3%	Explore
oligodendrocyte	8 studies	26% ± 7%	Explore
naive B cell	7 studies	18% ± 2%	Explore
monocyte	7 studies	21% ± 4%	Explore
classical monocyte	6 studies	25% ± 9%	Explore
B cell	6 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	20% ± 3%	Explore
glutamatergic neuron	6 studies	42% ± 19%	Explore
CD8-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
myeloid cell	6 studies	26% ± 9%	Explore
basal cell	6 studies	34% ± 13%	Explore
astrocyte	6 studies	28% ± 9%	Explore
oligodendrocyte precursor cell	6 studies	30% ± 11%	Explore
non-classical monocyte	5 studies	25% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	19% ± 2%	Explore
pericyte	5 studies	22% ± 2%	Explore
smooth muscle cell	5 studies	18% ± 2%	Explore
type I pneumocyte	5 studies	21% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	18% ± 2%	Explore
goblet cell	5 studies	32% ± 16%	Explore
squamous epithelial cell	4 studies	37% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
neuron	4 studies	28% ± 9%	Explore
myofibroblast cell	4 studies	18% ± 3%	Explore
mast cell	4 studies	21% ± 6%	Explore
adipocyte	4 studies	18% ± 5%	Explore
abnormal cell	4 studies	29% ± 10%	Explore
endothelial cell of lymphatic vessel	4 studies	23% ± 6%	Explore
GABAergic neuron	4 studies	45% ± 15%	Explore
alveolar macrophage	4 studies	23% ± 8%	Explore
gamma-delta T cell	4 studies	22% ± 9%	Explore
interneuron	4 studies	37% ± 19%	Explore
leukocyte	3 studies	20% ± 1%	Explore
CD4-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
conventional dendritic cell	3 studies	26% ± 8%	Explore
exhausted T cell	3 studies	20% ± 5%	Explore
mature NK T cell	3 studies	17% ± 1%	Explore
glomerular endothelial cell	3 studies	21% ± 0%	Explore
capillary endothelial cell	3 studies	17% ± 1%	Explore
club cell	3 studies	26% ± 4%	Explore
cardiac muscle cell	3 studies	17% ± 1%	Explore
lymphocyte	3 studies	26% ± 4%	Explore
respiratory goblet cell	3 studies	24% ± 9%	Explore
secretory cell	3 studies	33% ± 20%	Explore
endothelial cell of vascular tree	3 studies	22% ± 6%	Explore
endothelial cell of artery	3 studies	17% ± 1%	Explore
memory B cell	3 studies	18% ± 2%	Explore
dendritic cell	3 studies	35% ± 15%	Explore
enteroendocrine cell	3 studies	27% ± 7%	Explore
brush cell	3 studies	25% ± 8%	Explore
plasmacytoid dendritic cell	3 studies	20% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	33% ± 15%	Explore
lung	7 studies	29% ± 13%	Explore
peripheral blood	5 studies	23% ± 6%	Explore
intestine	3 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	8308.52	21 / 21	100%	62.04	504 / 504
breast	100%	9868.71	459 / 459	100%	64.77	1118 / 1118
esophagus	100%	7900.29	1445 / 1445	100%	39.31	183 / 183
kidney	100%	8022.60	89 / 89	100%	63.43	901 / 901
lung	100%	9833.65	578 / 578	100%	55.96	1155 / 1155
pancreas	100%	4162.68	328 / 328	100%	65.88	178 / 178
prostate	100%	8891.86	245 / 245	100%	56.20	502 / 502
stomach	100%	6833.36	359 / 359	100%	47.47	286 / 286
thymus	100%	9111.98	653 / 653	100%	62.87	605 / 605
uterus	100%	9588.25	170 / 170	100%	58.55	459 / 459
brain	100%	6157.91	2641 / 2642	100%	77.38	705 / 705
skin	100%	9155.77	1809 / 1809	100%	58.95	471 / 472
intestine	100%	9111.97	966 / 966	100%	56.86	525 / 527
adrenal gland	100%	7856.61	258 / 258	100%	49.54	229 / 230
ovary	100%	9348.12	180 / 180	100%	35.44	428 / 430
liver	100%	4098.31	226 / 226	99%	28.02	401 / 406
adipose	100%	9248.31	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	68.81	29 / 29
muscle	100%	5922.99	803 / 803	0%	0	0 / 0
spleen	100%	11170.73	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	50.17	45 / 45
ureter	0%	0	0 / 0	100%	37.39	1 / 1
blood vessel	100%	8208.52	1334 / 1335	0%	0	0 / 0
heart	100%	5469.49	857 / 861	0%	0	0 / 0
peripheral blood	99%	8220.05	920 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	48.01	79 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0036258	Biological process	multivesicular body assembly
GO_0048668	Biological process	collateral sprouting
GO_0046745	Biological process	viral capsid secondary envelopment
GO_0045862	Biological process	positive regulation of proteolysis
GO_0009838	Biological process	abscission
GO_0045184	Biological process	establishment of protein localization
GO_0061640	Biological process	cytoskeleton-dependent cytokinesis
GO_0051301	Biological process	cell division
GO_0019076	Biological process	viral release from host cell
GO_1904903	Biological process	ESCRT III complex disassembly
GO_0015031	Biological process	protein transport
GO_0008104	Biological process	protein localization
GO_0048672	Biological process	positive regulation of collateral sprouting
GO_0035578	Cellular component	azurophil granule lumen
GO_0030496	Cellular component	midbody
GO_0005576	Cellular component	extracellular region
GO_0005813	Cellular component	centrosome
GO_0070062	Cellular component	extracellular exosome
GO_0005635	Cellular component	nuclear envelope
GO_0090543	Cellular component	Flemming body
GO_0005829	Cellular component	cytosol
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0000785	Cellular component	chromatin
GO_0019904	Molecular function	protein domain specific binding
GO_0090541	Molecular function	MIT domain binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0045296	Molecular function	cadherin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IST1
Protein name	IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) IST1 factor associated with ESCRT-III IST1 homolog (Charged multivesicular body protein 8)
Synonyms	KIAA0174
Description	FUNCTION: ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation . Is required for efficient abscission during cytokinesis . Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells . During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing . Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 . Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST . .
Accessions	H3BQF7 ENST00000626438.1 ENST00000536027.1 J3KR23 ENST00000541571.6 [P53990-4] ENST00000544564.5 [P53990-4] ENST00000538104.5 ENST00000537613.5 ENST00000439924.6 H3BPP6 F5GXM3 ENST00000424485.6 J3QQP8 ENST00000541918.5 ENST00000329908.12 [P53990-3] ENST00000534994.5 ENST00000378798.9 [P53990-2] ENST00000568581.5 ENST00000456820.2 H3BQ38 E9PF00 H3BMU1 ENST00000538850.5 [P53990-6] ENST00000535424.5 [P53990-5] H3BUI0 H3BRE2 ENST00000540296.5 P53990 ENST00000378799.11 [P53990-4] ENST00000539186.5 ENST00000606369.5 [P53990-6]

IST1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review