Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 980.69 | 1443 / 1445 | 100% | 22.79 | 183 / 183 |
lung | 100% | 1478.26 | 578 / 578 | 100% | 18.80 | 1150 / 1155 |
intestine | 100% | 985.90 | 965 / 966 | 100% | 28.77 | 525 / 527 |
ovary | 100% | 980.41 | 180 / 180 | 99% | 17.30 | 426 / 430 |
thymus | 100% | 1168.43 | 653 / 653 | 98% | 16.31 | 595 / 605 |
brain | 98% | 1065.07 | 2598 / 2642 | 100% | 24.85 | 704 / 705 |
prostate | 99% | 774.87 | 242 / 245 | 99% | 19.66 | 498 / 502 |
pancreas | 98% | 628.34 | 323 / 328 | 99% | 17.04 | 177 / 178 |
stomach | 100% | 1058.70 | 358 / 359 | 98% | 25.62 | 280 / 286 |
breast | 100% | 1264.30 | 459 / 459 | 97% | 16.32 | 1087 / 1118 |
kidney | 100% | 914.01 | 89 / 89 | 97% | 15.32 | 870 / 901 |
bladder | 100% | 907.00 | 21 / 21 | 96% | 17.13 | 484 / 504 |
adrenal gland | 100% | 1667.38 | 258 / 258 | 96% | 20.19 | 220 / 230 |
uterus | 99% | 1063.84 | 169 / 170 | 95% | 11.55 | 434 / 459 |
skin | 100% | 1434.80 | 1806 / 1809 | 92% | 15.22 | 434 / 472 |
liver | 95% | 955.07 | 215 / 226 | 92% | 11.19 | 375 / 406 |
adipose | 100% | 1386.13 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1828.46 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 98% | 564.52 | 236 / 241 | 0% | 0 | 0 / 0 |
muscle | 97% | 589.94 | 776 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 10.11 | 42 / 45 |
heart | 92% | 1061.20 | 792 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 8.46 | 25 / 29 |
eye | 0% | 0 | 0 / 0 | 83% | 11.31 | 66 / 80 |
peripheral blood | 53% | 583.02 | 492 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006703 | Biological process | estrogen biosynthetic process |
GO_0030198 | Biological process | extracellular matrix organization |
GO_0019367 | Biological process | fatty acid elongation, saturated fatty acid |
GO_0035338 | Biological process | long-chain fatty-acyl-CoA biosynthetic process |
GO_0010811 | Biological process | positive regulation of cell-substrate adhesion |
GO_0009923 | Cellular component | fatty acid elongase complex |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0031012 | Cellular component | extracellular matrix |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0004303 | Molecular function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
GO_0008201 | Molecular function | heparin binding |
GO_0141040 | Molecular function | very-long-chain 3-oxoacyl-CoA reductase activity |
GO_0016491 | Molecular function | oxidoreductase activity |
GO_0005518 | Molecular function | collagen binding |
GO_0005515 | Molecular function | protein binding |
GO_0001968 | Molecular function | fibronectin binding |
Gene name | HSD17B12 |
Protein name | Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (Estradiol 17-beta-dehydrogenase 12) Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (Estradiol 17-beta-dehydrogenase 12) Hydroxysteroid 17-beta dehydrogenase 12 Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1) |
Synonyms | SDR12C1 |
Description | FUNCTION: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. . FUNCTION: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. . |
Accessions | Q53GQ0 ENST00000637401.1 ENST00000638034.1 A0A1B0GV93 A0A1B0GU83 ENST00000636722.1 A0A1B0GW85 E9PI21 ENST00000531185.5 A0A1B0GVY6 ENST00000395700.4 [Q53GQ0-2] ENST00000278353.10 [Q53GQ0-1] ENST00000527433.6 ENST00000636007.1 A0A1B0GW27 |