HSD17B12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006703Biological processestrogen biosynthetic process
GO_0030198Biological processextracellular matrix organization
GO_0019367Biological processfatty acid elongation, saturated fatty acid
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0010811Biological processpositive regulation of cell-substrate adhesion
GO_0009923Cellular componentfatty acid elongase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0031012Cellular componentextracellular matrix
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0008201Molecular functionheparin binding
GO_0141040Molecular functionvery-long-chain 3-oxoacyl-CoA reductase activity
GO_0016491Molecular functionoxidoreductase activity
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding
GO_0001968Molecular functionfibronectin binding

IV. Literature review

[source]
Gene nameHSD17B12
Protein nameVery-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (Estradiol 17-beta-dehydrogenase 12)
Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (Estradiol 17-beta-dehydrogenase 12)
Hydroxysteroid 17-beta dehydrogenase 12
Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1)
SynonymsSDR12C1
DescriptionFUNCTION: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. .

FUNCTION: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. .

AccessionsQ53GQ0
ENST00000637401.1
ENST00000638034.1
A0A1B0GV93
A0A1B0GU83
ENST00000636722.1
A0A1B0GW85
E9PI21
ENST00000531185.5
A0A1B0GVY6
ENST00000395700.4 [Q53GQ0-2]
ENST00000278353.10 [Q53GQ0-1]
ENST00000527433.6
ENST00000636007.1
A0A1B0GW27