HIKESHI | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	12 studies	25% ± 10%	Explore
smooth muscle cell	12 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	11 studies	21% ± 3%	Explore
fibroblast	11 studies	24% ± 10%	Explore
natural killer cell	11 studies	21% ± 6%	Explore
regulatory T cell	10 studies	20% ± 3%	Explore
pericyte	9 studies	23% ± 6%	Explore
CD4-positive, alpha-beta T cell	8 studies	22% ± 4%	Explore
myofibroblast cell	8 studies	22% ± 3%	Explore
connective tissue cell	8 studies	22% ± 7%	Explore
B cell	7 studies	21% ± 8%	Explore
basal cell	7 studies	25% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	19% ± 3%	Explore
T cell	6 studies	21% ± 4%	Explore
neuron	6 studies	28% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 4%	Explore
classical monocyte	5 studies	23% ± 7%	Explore
epithelial cell	5 studies	39% ± 19%	Explore
endothelial cell of lymphatic vessel	5 studies	23% ± 9%	Explore
ciliated cell	5 studies	31% ± 6%	Explore
oligodendrocyte	5 studies	23% ± 4%	Explore
hematopoietic precursor cell	4 studies	26% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
mature NK T cell	4 studies	17% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
plasma cell	4 studies	27% ± 13%	Explore
astrocyte	4 studies	28% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 2%	Explore
oligodendrocyte precursor cell	4 studies	26% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	23% ± 9%	Explore
gamma-delta T cell	4 studies	29% ± 22%	Explore
plasmacytoid dendritic cell	4 studies	22% ± 5%	Explore
memory B cell	4 studies	17% ± 1%	Explore
plasmablast	3 studies	51% ± 11%	Explore
conventional dendritic cell	3 studies	38% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
non-classical monocyte	3 studies	27% ± 5%	Explore
mesothelial cell	3 studies	30% ± 17%	Explore
neural crest cell	3 studies	22% ± 3%	Explore
precursor B cell	3 studies	27% ± 12%	Explore
pro-B cell	3 studies	24% ± 2%	Explore
rod bipolar cell	3 studies	24% ± 4%	Explore
erythroblast	3 studies	36% ± 25%	Explore
T follicular helper cell	3 studies	16% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
exhausted T cell	3 studies	19% ± 3%	Explore
macrophage	3 studies	28% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
abnormal cell	3 studies	22% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	35% ± 21%	Explore
GABAergic neuron	3 studies	30% ± 10%	Explore
glutamatergic neuron	3 studies	34% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	21% ± 5%	Explore
lung	5 studies	28% ± 6%	Explore
brain	4 studies	27% ± 7%	Explore
kidney	3 studies	16% ± 2%	Explore
liver	3 studies	35% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1636.72	1445 / 1445	100%	21.55	183 / 183
ovary	100%	2202.16	180 / 180	100%	33.68	430 / 430
stomach	100%	1040.61	359 / 359	100%	20.89	286 / 286
skin	100%	1463.32	1808 / 1809	100%	23.58	472 / 472
brain	100%	1367.62	2639 / 2642	100%	34.01	705 / 705
thymus	100%	1241.27	653 / 653	100%	21.78	604 / 605
breast	100%	1692.86	459 / 459	100%	22.82	1116 / 1118
intestine	100%	1617.46	966 / 966	100%	21.39	526 / 527
bladder	100%	1743.14	21 / 21	100%	25.47	503 / 504
uterus	100%	2164.56	170 / 170	100%	29.67	458 / 459
lung	100%	1269.10	576 / 578	100%	24.31	1155 / 1155
prostate	100%	1457.11	245 / 245	100%	18.19	500 / 502
adrenal gland	100%	1403.73	258 / 258	100%	23.06	229 / 230
kidney	100%	976.37	89 / 89	100%	15.21	897 / 901
pancreas	99%	651.42	326 / 328	100%	21.96	178 / 178
liver	99%	714.88	224 / 226	99%	14.44	403 / 406
adipose	100%	1700.75	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1924.60	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	24.33	80 / 80
lymph node	0%	0	0 / 0	100%	40.43	29 / 29
spleen	100%	1559.04	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	23.34	45 / 45
ureter	0%	0	0 / 0	100%	13.38	1 / 1
muscle	100%	1579.04	802 / 803	0%	0	0 / 0
heart	99%	1452.75	853 / 861	0%	0	0 / 0
peripheral blood	87%	817.60	810 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0015031	Biological process	protein transport
GO_0007030	Biological process	Golgi organization
GO_0030324	Biological process	lung development
GO_0034605	Biological process	cellular response to heat
GO_0006606	Biological process	protein import into nucleus
GO_0016607	Cellular component	nuclear speck
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0030544	Molecular function	Hsp70 protein binding
GO_0061608	Molecular function	nuclear import signal receptor activity

IV. Literature review

[source]

Gene name	HIKESHI
Protein name	Protein Hikeshi
Synonyms	HSPC138 HSPC248 HSPC179 C11orf73
Description	FUNCTION: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. . FUNCTION: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. . FUNCTION: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. .
Accessions	E9PJB2 ENST00000528004.5 ENST00000278483.8 Q53FT3 E9PPG8 ENST00000533986.5

HIKESHI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review