GTF2H5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006289Biological processnucleotide-excision repair
GO_0006366Biological processtranscription by RNA polymerase II
GO_0006362Biological processtranscription elongation by RNA polymerase I
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006294Biological processnucleotide-excision repair, preincision complex assembly
GO_0000462Biological processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0071480Biological processcellular response to gamma radiation
GO_0005730Cellular componentnucleolus
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0000439Cellular componenttranscription factor TFIIH core complex
GO_0005675Cellular componenttranscription factor TFIIH holo complex
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGTF2H5
Protein nameGeneral transcription factor IIH subunit 5
General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) (TFIIH subunit p8)
SynonymsTTDA
C6orf175
DescriptionFUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. .

AccessionsA0A8I5KQH8
A0A3B3ISL4
ENST00000689809.1
Q6ZYL4
ENST00000607778.2
ENST00000691867.1
ENST00000689383.1
ENST00000648328.1