GIGYF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009791Biological processpost-embryonic development
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0007631Biological processfeeding behavior
GO_0008344Biological processadult locomotory behavior
GO_0050885Biological processneuromuscular process controlling balance
GO_0035264Biological processmulticellular organism growth
GO_0016441Biological processpost-transcriptional gene silencing
GO_0061157Biological processmRNA destabilization
GO_0072344Biological processrescue of stalled ribosome
GO_0048873Biological processhomeostasis of number of cells within a tissue
GO_0045947Biological processnegative regulation of translational initiation
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0031571Biological processmitotic G1 DNA damage checkpoint signaling
GO_0050881Biological processmusculoskeletal movement
GO_0021522Biological processspinal cord motor neuron differentiation
GO_0017148Biological processnegative regulation of translation
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_1990635Cellular componentproximal dendrite
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005768Cellular componentendosome
GO_0031982Cellular componentvesicle
GO_0010494Cellular componentcytoplasmic stress granule
GO_0060090Molecular functionmolecular adaptor activity
GO_0070064Molecular functionproline-rich region binding
GO_0045296Molecular functioncadherin binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGIGYF2
Protein nameGRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein)
GRB10 interacting GYF protein 2
SynonymsPERQ2
KIAA0642
TNRC15
DescriptionFUNCTION: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation . In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay . Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA . May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors . In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide . GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist . .; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. .

AccessionsENST00000677450.1
C9JXQ0
C9JPV7
C9JHW1
I1E4Y6
ENST00000488734.5
ENST00000490612.5
C9JHT0
ENST00000424038.2
C9JW88
A0A7I2V3X3
ENST00000629305.2
ENST00000678230.1
A0A7I2V3H0
ENST00000475359.6
ENST00000421433.5
ENST00000425040.5
ENST00000490229.5
A0A7I2V516
ENST00000409547.5 [Q6Y7W6-1]
ENST00000464805.5
ENST00000456491.5
ENST00000489328.1
ENST00000464402.5
ENST00000373563.9 [Q6Y7W6-1]
A0A7I2V3H7
F8WBF1
ENST00000483164.5
C9JC65
Q6Y7W6
ENST00000476995.5
C9JRZ2
ENST00000492910.5
ENST00000678339.1
ENST00000676848.1
ENST00000409451.7 [Q6Y7W6-3]
ENST00000678466.1
E7ESB6
ENST00000458528.1
ENST00000409480.5
ENST00000429187.5
ENST00000440945.5
A0A7I2V361
ENST00000678885.1
ENST00000423659.5
A0A7I2YQP8
ENST00000430720.5
ENST00000409196.7 [Q6Y7W6-5]
F8WCD5
ENST00000677591.1
ENST00000428883.5
ENST00000427233.5
ENST00000482666.5
C9J0V6