GABARAPL1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	24 studies	28% ± 10%	Explore
endothelial cell	22 studies	25% ± 7%	Explore
fibroblast	17 studies	33% ± 14%	Explore
classical monocyte	16 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	14 studies	23% ± 6%	Explore
gamma-delta T cell	14 studies	30% ± 13%	Explore
macrophage	13 studies	23% ± 5%	Explore
non-classical monocyte	12 studies	31% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	23% ± 9%	Explore
mature NK T cell	12 studies	24% ± 7%	Explore
pericyte	12 studies	29% ± 12%	Explore
T cell	11 studies	26% ± 9%	Explore
smooth muscle cell	11 studies	28% ± 12%	Explore
conventional dendritic cell	11 studies	30% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	30% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	26% ± 8%	Explore
endothelial cell of vascular tree	9 studies	26% ± 7%	Explore
monocyte	8 studies	23% ± 11%	Explore
endothelial cell of lymphatic vessel	8 studies	26% ± 6%	Explore
capillary endothelial cell	8 studies	24% ± 3%	Explore
retinal rod cell	8 studies	35% ± 16%	Explore
epithelial cell	8 studies	39% ± 16%	Explore
basal cell	8 studies	26% ± 8%	Explore
endothelial cell of artery	8 studies	28% ± 7%	Explore
alveolar macrophage	7 studies	23% ± 6%	Explore
glutamatergic neuron	7 studies	40% ± 22%	Explore
dendritic cell	6 studies	28% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	32% ± 13%	Explore
kidney loop of Henle epithelial cell	6 studies	32% ± 6%	Explore
renal alpha-intercalated cell	6 studies	55% ± 18%	Explore
retinal cone cell	6 studies	46% ± 28%	Explore
regulatory T cell	6 studies	21% ± 3%	Explore
connective tissue cell	6 studies	25% ± 10%	Explore
leukocyte	5 studies	30% ± 8%	Explore
epithelial cell of proximal tubule	5 studies	22% ± 5%	Explore
neuron	5 studies	33% ± 10%	Explore
retinal ganglion cell	5 studies	73% ± 32%	Explore
astrocyte	5 studies	30% ± 9%	Explore
myeloid cell	5 studies	28% ± 10%	Explore
cardiac muscle cell	5 studies	21% ± 4%	Explore
vein endothelial cell	5 studies	24% ± 11%	Explore
secretory cell	5 studies	23% ± 7%	Explore
type I pneumocyte	4 studies	28% ± 7%	Explore
CD4-positive, alpha-beta T cell	4 studies	21% ± 5%	Explore
mesothelial cell	4 studies	38% ± 17%	Explore
amacrine cell	4 studies	43% ± 17%	Explore
retina horizontal cell	4 studies	33% ± 11%	Explore
Mueller cell	4 studies	32% ± 4%	Explore
innate lymphoid cell	4 studies	27% ± 11%	Explore
GABAergic neuron	4 studies	45% ± 7%	Explore
ionocyte	3 studies	25% ± 2%	Explore
squamous epithelial cell	3 studies	37% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	39% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	31% ± 8%	Explore
retinal bipolar neuron	3 studies	42% ± 13%	Explore
ON-bipolar cell	3 studies	51% ± 36%	Explore
glycinergic amacrine cell	3 studies	28% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	64% ± 1%	Explore
renal principal cell	3 studies	50% ± 13%	Explore
placental villous trophoblast	3 studies	58% ± 2%	Explore
mucosal invariant T cell	3 studies	35% ± 1%	Explore
retinal pigment epithelial cell	3 studies	36% ± 13%	Explore
lymphocyte	3 studies	35% ± 7%	Explore
intermediate monocyte	3 studies	45% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	27% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 9%	Explore
neutrophil	3 studies	21% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 4%	Explore
oligodendrocyte	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	9 studies	36% ± 13%	Explore
lung	7 studies	25% ± 8%	Explore
kidney	7 studies	21% ± 5%	Explore
brain	7 studies	32% ± 14%	Explore
peripheral blood	5 studies	28% ± 7%	Explore
placenta	4 studies	25% ± 9%	Explore
uterus	4 studies	24% ± 3%	Explore
breast	3 studies	19% ± 2%	Explore
prostate	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	23318.51	89 / 89	100%	119.18	899 / 901
thymus	100%	9234.90	651 / 653	100%	72.22	602 / 605
prostate	100%	8752.49	244 / 245	100%	71.26	500 / 502
brain	99%	16366.94	2615 / 2642	100%	108.99	704 / 705
adrenal gland	99%	7617.67	256 / 258	99%	141.19	227 / 230
lung	100%	12983.73	577 / 578	96%	59.39	1110 / 1155
liver	100%	9551.91	226 / 226	95%	61.49	385 / 406
breast	100%	13775.05	459 / 459	95%	38.13	1060 / 1118
pancreas	92%	7346.26	303 / 328	99%	62.18	177 / 178
bladder	100%	9552.81	21 / 21	91%	36.42	458 / 504
uterus	98%	7595.32	167 / 170	92%	36.68	423 / 459
skin	90%	5281.54	1627 / 1809	97%	41.58	458 / 472
ovary	99%	12796.27	179 / 180	80%	21.74	343 / 430
esophagus	89%	8209.86	1288 / 1445	88%	33.46	161 / 183
stomach	100%	9560.14	359 / 359	76%	20.16	216 / 286
intestine	97%	7523.29	939 / 966	77%	21.94	406 / 527
adipose	100%	15569.60	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10540.96	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	55.17	80 / 80
ureter	0%	0	0 / 0	100%	12.09	1 / 1
muscle	100%	19262.69	802 / 803	0%	0	0 / 0
heart	98%	18121.41	845 / 861	0%	0	0 / 0
spleen	92%	4178.71	221 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	34.23	41 / 45
peripheral blood	74%	4700.40	688 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	62%	12.67	18 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000045	Biological process	autophagosome assembly
GO_0000422	Biological process	autophagy of mitochondrion
GO_0097352	Biological process	autophagosome maturation
GO_0006995	Biological process	cellular response to nitrogen starvation
GO_0061723	Biological process	glycophagy
GO_0005874	Cellular component	microtubule
GO_0005739	Cellular component	mitochondrion
GO_0000421	Cellular component	autophagosome membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005776	Cellular component	autophagosome
GO_0030659	Cellular component	cytoplasmic vesicle membrane
GO_0048487	Molecular function	beta-tubulin binding
GO_0005543	Molecular function	phospholipid binding
GO_0030957	Molecular function	Tat protein binding
GO_0050811	Molecular function	GABA receptor binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0008429	Molecular function	phosphatidylethanolamine binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GABARAPL1
Protein name	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) GABA type A receptor associated protein like 1 (GABA(A) receptor-associated protein like 1, isoform CRA_e) GABA type A receptor associated protein like 1 Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
Synonyms	GEC1 hCG_38151
Description	FUNCTION: Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor . Involved in formation of autophagosomal vacuoles . While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation . Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover . .
Accessions	ENST00000545859.5 ENST00000542722.5 ENST00000535576.5 ENST00000539170.5 ENST00000537201.5 ENST00000266458.10 [Q9H0R8-1] F5GZY7 ENST00000540424.5 ENST00000541960.5 ENST00000629504.1 F5GYD9 ENST00000544284.5 G3V1T7 F5GX12 ENST00000421801.6 [Q9H0R8-2] ENST00000541453.1 ENST00000539408.5 ENST00000545887.1 [Q9H0R8-1] ENST00000545047.5 ENST00000546017.5 Q9H0R8 F5H007 A0A0G2JKT8 ENST00000543602.5 [Q9H0R8-2] ENST00000545290.1

GABARAPL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review