FGR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043306Biological processpositive regulation of mast cell degranulation
GO_0002768Biological processimmune response-regulating cell surface receptor signaling pathway
GO_0045859Biological processregulation of protein kinase activity
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0045087Biological processinnate immune response
GO_0009615Biological processresponse to virus
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0045088Biological processregulation of innate immune response
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0030335Biological processpositive regulation of cell migration
GO_0051450Biological processmyoblast proliferation
GO_0032815Biological processnegative regulation of natural killer cell activation
GO_0030154Biological processcell differentiation
GO_0030282Biological processbone mineralization
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0050764Biological processregulation of phagocytosis
GO_0008360Biological processregulation of cell shape
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0001819Biological processpositive regulation of cytokine production
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0048705Biological processskeletal system morphogenesis
GO_0032587Cellular componentruffle membrane
GO_0005856Cellular componentcytoskeleton
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016235Cellular componentaggresome
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0070062Cellular componentextracellular exosome
GO_0005743Cellular componentmitochondrial inner membrane
GO_0034774Cellular componentsecretory granule lumen
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0034987Molecular functionimmunoglobulin receptor binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0005102Molecular functionsignaling receptor binding
GO_0034988Molecular functionFc-gamma receptor I complex binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene nameFGR
Protein nameC-src-2 protein
Tyrosine-protein kinase (EC 2.7.10.2)
Alternative protein FGR
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
SynonymsSRC2
DescriptionFUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). .

AccessionsQ5TGY6
ENST00000374004.5
L8E733
ENST00000374005.8
ENST00000399173.5
P09769
P78483
ENST00000374003.7
ENST00000457296.5