Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 29 studies | 33% ± 11% | |
classical monocyte | 26 studies | 56% ± 18% | |
non-classical monocyte | 25 studies | 63% ± 18% | |
monocyte | 23 studies | 40% ± 13% | |
conventional dendritic cell | 22 studies | 38% ± 18% | |
macrophage | 16 studies | 29% ± 11% | |
CD16-positive, CD56-dim natural killer cell, human | 14 studies | 43% ± 15% | |
dendritic cell | 14 studies | 36% ± 17% | |
CD16-negative, CD56-bright natural killer cell, human | 13 studies | 31% ± 13% | |
myeloid cell | 10 studies | 40% ± 23% | |
B cell | 9 studies | 29% ± 15% | |
mature NK T cell | 9 studies | 29% ± 10% | |
neutrophil | 9 studies | 40% ± 16% | |
alveolar macrophage | 7 studies | 37% ± 5% | |
gamma-delta T cell | 7 studies | 22% ± 5% | |
CD8-positive, alpha-beta T cell | 5 studies | 22% ± 4% | |
mononuclear phagocyte | 4 studies | 32% ± 17% | |
intermediate monocyte | 4 studies | 73% ± 21% | |
memory B cell | 4 studies | 23% ± 6% | |
innate lymphoid cell | 3 studies | 34% ± 8% | |
effector memory CD8-positive, alpha-beta T cell, terminally differentiated | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 11437.23 | 578 / 578 | 96% | 18.19 | 1111 / 1155 |
breast | 96% | 2088.80 | 439 / 459 | 91% | 10.02 | 1022 / 1118 |
thymus | 79% | 949.04 | 514 / 653 | 93% | 11.84 | 563 / 605 |
bladder | 86% | 1330.62 | 18 / 21 | 84% | 9.72 | 424 / 504 |
uterus | 86% | 1178.46 | 146 / 170 | 82% | 8.59 | 375 / 459 |
prostate | 71% | 883.29 | 173 / 245 | 76% | 4.84 | 384 / 502 |
kidney | 47% | 575.73 | 42 / 89 | 90% | 16.08 | 812 / 901 |
brain | 34% | 350.62 | 903 / 2642 | 97% | 10.85 | 687 / 705 |
esophagus | 48% | 527.66 | 689 / 1445 | 82% | 7.57 | 150 / 183 |
intestine | 56% | 710.36 | 541 / 966 | 74% | 7.60 | 388 / 527 |
stomach | 37% | 472.58 | 132 / 359 | 81% | 8.61 | 231 / 286 |
adrenal gland | 64% | 694.10 | 164 / 258 | 45% | 2.75 | 103 / 230 |
pancreas | 14% | 151.41 | 45 / 328 | 89% | 16.47 | 159 / 178 |
skin | 24% | 242.72 | 442 / 1809 | 76% | 10.17 | 360 / 472 |
lymph node | 0% | 0 | 0 / 0 | 100% | 58.43 | 29 / 29 |
spleen | 100% | 17594.22 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 53461.86 | 928 / 929 | 0% | 0 | 0 / 0 |
adipose | 98% | 3033.18 | 1177 / 1204 | 0% | 0 | 0 / 0 |
liver | 47% | 561.85 | 107 / 226 | 50% | 3.81 | 203 / 406 |
tonsil | 0% | 0 | 0 / 0 | 89% | 14.65 | 40 / 45 |
ovary | 16% | 165.10 | 29 / 180 | 66% | 5.24 | 285 / 430 |
blood vessel | 47% | 766.41 | 625 / 1335 | 0% | 0 | 0 / 0 |
heart | 40% | 455.74 | 347 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 16% | 0.92 | 13 / 80 |
muscle | 4% | 34.21 | 34 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0043306 | Biological process | positive regulation of mast cell degranulation |
GO_0002768 | Biological process | immune response-regulating cell surface receptor signaling pathway |
GO_0045859 | Biological process | regulation of protein kinase activity |
GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
GO_0045087 | Biological process | innate immune response |
GO_0009615 | Biological process | response to virus |
GO_0002862 | Biological process | negative regulation of inflammatory response to antigenic stimulus |
GO_0045088 | Biological process | regulation of innate immune response |
GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
GO_0007229 | Biological process | integrin-mediated signaling pathway |
GO_0050830 | Biological process | defense response to Gram-positive bacterium |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_0051450 | Biological process | myoblast proliferation |
GO_0032815 | Biological process | negative regulation of natural killer cell activation |
GO_0030154 | Biological process | cell differentiation |
GO_0030282 | Biological process | bone mineralization |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0050764 | Biological process | regulation of phagocytosis |
GO_0008360 | Biological process | regulation of cell shape |
GO_0038096 | Biological process | Fc-gamma receptor signaling pathway involved in phagocytosis |
GO_0001819 | Biological process | positive regulation of cytokine production |
GO_0006468 | Biological process | protein phosphorylation |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0048705 | Biological process | skeletal system morphogenesis |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005856 | Cellular component | cytoskeleton |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0016235 | Cellular component | aggresome |
GO_0005758 | Cellular component | mitochondrial intermembrane space |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0034774 | Cellular component | secretory granule lumen |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005829 | Cellular component | cytosol |
GO_0004715 | Molecular function | non-membrane spanning protein tyrosine kinase activity |
GO_0034987 | Molecular function | immunoglobulin receptor binding |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0019901 | Molecular function | protein kinase binding |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0034988 | Molecular function | Fc-gamma receptor I complex binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
GO_0001784 | Molecular function | phosphotyrosine residue binding |
Gene name | FGR |
Protein name | C-src-2 protein Tyrosine-protein kinase (EC 2.7.10.2) Alternative protein FGR Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) |
Synonyms | SRC2 |
Description | FUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). . |
Accessions | Q5TGY6 ENST00000374004.5 L8E733 ENST00000374005.8 ENST00000399173.5 P09769 P78483 ENST00000374003.7 ENST00000457296.5 |