ETHE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070813Biological processhydrogen sulfide metabolic process
GO_0006749Biological processglutathione metabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0050313Molecular functionsulfur dioxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameETHE1
Protein nameEthylmalonic encephalopathy 1, isoform CRA_a (cDNA, FLJ96390, highly similar to Homo sapiens protein expressed in thyroid (YF13H12), mRNA)
Ethylmalonic encephalopathy 1 isoform 2
ETHE1 persulfide dioxygenase
Ethylmalonic encephalopathy 1 isoform 1 (Ethylmalonic encephalopathy 1, isoform CRA_b)
Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Ethylmalonic encephalopathy protein 1) (Hepatoma subtracted clone one protein) (Sulfur dioxygenase ETHE1)
Ethylmalonic encephalopathy 1 isoform 3
SynonymsHSCO
hCG_1995670
DescriptionFUNCTION: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus . .

AccessionsENST00000598330.1
B2RCZ7
A0A0S2Z5B3
A0A0S2Z5N8
ENST00000292147.7
ENST00000602138.1
M0QX80
ENST00000600651.5
M0QXB5
M0QY80
A0A0S2Z580
ENST00000594342.5
O95571