ETF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	22 studies	22% ± 7%	Explore
classical monocyte	18 studies	26% ± 9%	Explore
fibroblast	15 studies	24% ± 8%	Explore
endothelial cell	14 studies	24% ± 5%	Explore
monocyte	13 studies	27% ± 9%	Explore
conventional dendritic cell	12 studies	28% ± 11%	Explore
non-classical monocyte	11 studies	27% ± 11%	Explore
basal cell	11 studies	30% ± 12%	Explore
epithelial cell	9 studies	34% ± 20%	Explore
B cell	8 studies	19% ± 5%	Explore
T cell	8 studies	21% ± 10%	Explore
natural killer cell	8 studies	24% ± 6%	Explore
plasmacytoid dendritic cell	8 studies	26% ± 10%	Explore
dendritic cell	7 studies	35% ± 18%	Explore
type I pneumocyte	7 studies	29% ± 8%	Explore
pericyte	7 studies	20% ± 4%	Explore
mononuclear phagocyte	6 studies	23% ± 7%	Explore
ciliated cell	6 studies	36% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 3%	Explore
mast cell	5 studies	22% ± 7%	Explore
smooth muscle cell	5 studies	21% ± 3%	Explore
neutrophil	5 studies	23% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	21% ± 4%	Explore
CD4-positive, alpha-beta T cell	5 studies	25% ± 11%	Explore
memory B cell	5 studies	20% ± 3%	Explore
connective tissue cell	5 studies	18% ± 2%	Explore
myeloid cell	5 studies	38% ± 8%	Explore
gamma-delta T cell	5 studies	27% ± 8%	Explore
endothelial cell of vascular tree	5 studies	22% ± 3%	Explore
type II pneumocyte	4 studies	22% ± 8%	Explore
pancreatic A cell	4 studies	28% ± 8%	Explore
naive B cell	4 studies	20% ± 3%	Explore
hematopoietic precursor cell	4 studies	31% ± 14%	Explore
lymphocyte	4 studies	20% ± 9%	Explore
mucosal invariant T cell	4 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	4 studies	25% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	24% ± 7%	Explore
regulatory T cell	4 studies	23% ± 7%	Explore
endothelial cell of lymphatic vessel	3 studies	19% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	26% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	24% ± 6%	Explore
abnormal cell	3 studies	23% ± 5%	Explore
placental villous trophoblast	3 studies	36% ± 23%	Explore
club cell	3 studies	26% ± 8%	Explore
retinal pigment epithelial cell	3 studies	26% ± 8%	Explore
tissue-resident macrophage	3 studies	23% ± 8%	Explore
secretory cell	3 studies	32% ± 10%	Explore
vein endothelial cell	3 studies	26% ± 6%	Explore
muscle cell	3 studies	22% ± 3%	Explore
GABAergic neuron	3 studies	33% ± 5%	Explore
glutamatergic neuron	3 studies	42% ± 7%	Explore
goblet cell	3 studies	27% ± 11%	Explore
transit amplifying cell	3 studies	27% ± 11%	Explore
erythroblast	3 studies	29% ± 12%	Explore
astrocyte	3 studies	21% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	25% ± 7%	Explore
lung	7 studies	27% ± 11%	Explore
uterus	5 studies	21% ± 8%	Explore
brain	5 studies	29% ± 5%	Explore
placenta	4 studies	21% ± 5%	Explore
pancreas	3 studies	30% ± 11%	Explore
bone marrow	3 studies	18% ± 3%	Explore
eye	3 studies	24% ± 6%	Explore
breast	3 studies	22% ± 6%	Explore
liver	3 studies	29% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8747.39	1445 / 1445	100%	91.86	183 / 183
intestine	100%	6972.71	966 / 966	100%	91.29	527 / 527
lung	100%	8533.13	578 / 578	100%	92.20	1155 / 1155
ovary	100%	5027.68	180 / 180	100%	63.51	430 / 430
stomach	100%	5954.16	359 / 359	100%	81.64	286 / 286
uterus	100%	5767.21	170 / 170	100%	104.45	459 / 459
breast	100%	7392.53	459 / 459	100%	116.98	1117 / 1118
bladder	100%	7156.29	21 / 21	100%	83.71	503 / 504
prostate	100%	5935.96	245 / 245	100%	80.31	501 / 502
pancreas	100%	3326.20	327 / 328	100%	80.53	178 / 178
brain	99%	3536.30	2620 / 2642	100%	76.39	705 / 705
thymus	100%	5453.23	651 / 653	99%	83.10	601 / 605
skin	100%	10512.03	1809 / 1809	99%	118.01	467 / 472
kidney	100%	4898.04	89 / 89	99%	74.56	891 / 901
liver	99%	3276.95	223 / 226	100%	52.05	404 / 406
adrenal gland	100%	7164.70	258 / 258	96%	74.46	221 / 230
adipose	100%	8313.84	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7558.01	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	100.54	29 / 29
muscle	100%	8775.20	803 / 803	0%	0	0 / 0
spleen	100%	4704.48	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	120.06	45 / 45
ureter	0%	0	0 / 0	100%	18.09	1 / 1
eye	0%	0	0 / 0	96%	76.77	77 / 80
peripheral blood	96%	5366.67	894 / 929	0%	0	0 / 0
heart	95%	5005.33	820 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006479	Biological process	protein methylation
GO_0002184	Biological process	cytoplasmic translational termination
GO_0000184	Biological process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0006415	Biological process	translational termination
GO_0006449	Biological process	regulation of translational termination
GO_0018444	Cellular component	translation release factor complex
GO_0022626	Cellular component	cytosolic ribosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0043022	Molecular function	ribosome binding
GO_1990825	Molecular function	sequence-specific mRNA binding
GO_0004045	Molecular function	aminoacyl-tRNA hydrolase activity
GO_0008079	Molecular function	translation termination factor activity
GO_0005515	Molecular function	protein binding
GO_0003747	Molecular function	translation release factor activity
GO_0016149	Molecular function	translation release factor activity, codon specific
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	ETF1
Protein name	Eukaryotic peptide chain release factor subunit 1 Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)
Synonyms	SUP45L1 ERF1 RF1
Description	FUNCTION: Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons . The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site . ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA . Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA . Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons . Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes . .
Accessions	ENST00000503014.5 ENST00000512198.1 I3L492 P62495 D6RCB3 ENST00000572514.5 ENST00000507939.5 ENST00000499810.6 [P62495-2] D6RJE8 ENST00000360541.10 [P62495-1] B7Z7P8

ETF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review