ESYT2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	29 studies	43% ± 22%	Explore
fibroblast	17 studies	29% ± 13%	Explore
pericyte	15 studies	33% ± 15%	Explore
ciliated cell	12 studies	30% ± 11%	Explore
glutamatergic neuron	12 studies	41% ± 24%	Explore
smooth muscle cell	12 studies	38% ± 10%	Explore
astrocyte	12 studies	29% ± 10%	Explore
oligodendrocyte precursor cell	9 studies	28% ± 11%	Explore
oligodendrocyte	9 studies	26% ± 8%	Explore
type I pneumocyte	8 studies	32% ± 13%	Explore
macrophage	8 studies	31% ± 12%	Explore
microglial cell	8 studies	28% ± 14%	Explore
epithelial cell	8 studies	41% ± 20%	Explore
adipocyte	8 studies	36% ± 12%	Explore
T cell	8 studies	30% ± 9%	Explore
GABAergic neuron	8 studies	47% ± 22%	Explore
natural killer cell	7 studies	28% ± 10%	Explore
myeloid cell	7 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	23% ± 7%	Explore
CD4-positive, alpha-beta T cell	6 studies	25% ± 5%	Explore
interneuron	6 studies	48% ± 24%	Explore
capillary endothelial cell	6 studies	34% ± 19%	Explore
dendritic cell	6 studies	28% ± 11%	Explore
mast cell	6 studies	28% ± 11%	Explore
endothelial cell of lymphatic vessel	6 studies	31% ± 14%	Explore
type II pneumocyte	6 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
neuron	5 studies	37% ± 10%	Explore
cardiac muscle cell	5 studies	26% ± 5%	Explore
vein endothelial cell	5 studies	38% ± 26%	Explore
monocyte	5 studies	28% ± 5%	Explore
club cell	5 studies	32% ± 11%	Explore
basal cell	5 studies	34% ± 22%	Explore
squamous epithelial cell	4 studies	39% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	28% ± 4%	Explore
hematopoietic precursor cell	4 studies	32% ± 14%	Explore
granule cell	4 studies	31% ± 4%	Explore
retinal ganglion cell	4 studies	30% ± 17%	Explore
endothelial cell of artery	4 studies	27% ± 9%	Explore
mesothelial cell	4 studies	26% ± 7%	Explore
lymphocyte	4 studies	36% ± 15%	Explore
endothelial cell of vascular tree	4 studies	40% ± 23%	Explore
respiratory goblet cell	4 studies	39% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	30% ± 9%	Explore
GABAergic interneuron	3 studies	34% ± 5%	Explore
myofibroblast cell	3 studies	38% ± 10%	Explore
plasma cell	3 studies	27% ± 4%	Explore
Mueller cell	3 studies	46% ± 18%	Explore
amacrine cell	3 studies	35% ± 12%	Explore
gamma-delta T cell	3 studies	27% ± 2%	Explore
muscle cell	3 studies	45% ± 31%	Explore
abnormal cell	3 studies	26% ± 7%	Explore
connective tissue cell	3 studies	23% ± 7%	Explore
hematopoietic stem cell	3 studies	24% ± 5%	Explore
adventitial cell	3 studies	29% ± 7%	Explore
alveolar macrophage	3 studies	30% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	21% ± 4%	Explore
regulatory T cell	3 studies	21% ± 4%	Explore
goblet cell	3 studies	46% ± 29%	Explore
renal principal cell	3 studies	28% ± 5%	Explore
mural cell	3 studies	61% ± 6%	Explore
mucus secreting cell	3 studies	35% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	35% ± 18%	Explore
lung	7 studies	24% ± 8%	Explore
heart	4 studies	29% ± 5%	Explore
eye	4 studies	34% ± 21%	Explore
peripheral blood	3 studies	28% ± 6%	Explore
adipose	3 studies	28% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	12249.08	1445 / 1445	100%	74.09	183 / 183
stomach	100%	5257.36	358 / 359	100%	65.61	286 / 286
intestine	100%	9270.02	966 / 966	100%	66.73	525 / 527
breast	100%	10058.50	459 / 459	100%	85.73	1113 / 1118
lung	99%	8488.70	575 / 578	100%	78.47	1154 / 1155
uterus	100%	10068.51	170 / 170	99%	62.07	455 / 459
ovary	100%	14066.47	180 / 180	99%	59.55	426 / 430
kidney	100%	4623.57	89 / 89	99%	85.57	892 / 901
bladder	100%	9830.38	21 / 21	99%	56.39	497 / 504
prostate	100%	7000.42	244 / 245	99%	51.30	497 / 502
thymus	100%	8001.73	652 / 653	99%	60.90	597 / 605
skin	100%	9422.13	1808 / 1809	98%	86.82	464 / 472
brain	98%	4688.69	2577 / 2642	99%	41.82	701 / 705
adrenal gland	100%	8451.68	258 / 258	97%	53.88	222 / 230
pancreas	95%	3414.80	312 / 328	98%	72.44	175 / 178
liver	86%	2179.53	194 / 226	87%	26.79	354 / 406
adipose	100%	11837.10	1204 / 1204	0%	0	0 / 0
blood vessel	100%	18802.97	1335 / 1335	0%	0	0 / 0
spleen	100%	3735.16	241 / 241	0%	0	0 / 0
muscle	100%	7696.00	802 / 803	0%	0	0 / 0
heart	99%	6535.15	855 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	49.89	44 / 45
eye	0%	0	0 / 0	89%	40.61	71 / 80
lymph node	0%	0	0 / 0	79%	27.19	23 / 29
peripheral blood	65%	2684.94	606 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0061817	Biological process	endoplasmic reticulum-plasma membrane tethering
GO_0006897	Biological process	endocytosis
GO_0006869	Biological process	lipid transport
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0140268	Cellular component	endoplasmic reticulum-plasma membrane contact site
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0044232	Cellular component	organelle membrane contact site
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0045296	Molecular function	cadherin binding
GO_0008429	Molecular function	phosphatidylethanolamine binding
GO_0031210	Molecular function	phosphatidylcholine binding
GO_0005509	Molecular function	calcium ion binding
GO_0005544	Molecular function	calcium-dependent phospholipid binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0035091	Molecular function	phosphatidylinositol binding

IV. Literature review

[source]

Gene name	ESYT2
Protein name	Extended synaptotagmin 2 Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) Extended synaptotagmin 2 (Family with sequence similarity 62 (C2 domain containing) member B, isoform CRA_b)
Synonyms	hCG_20178 FAM62B KIAA1228
Description	FUNCTION: Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) . .
Accessions	ENST00000275418.13 ENST00000251527.10 H7BXI1 ENST00000652148.1 [A0FGR8-2] A0FGR8 A0A499FIX8

ESYT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review