ERAP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008217Biological processregulation of blood pressure
GO_0002250Biological processadaptive immune response
GO_0002474Biological processantigen processing and presentation of peptide antigen via MHC class I
GO_0043171Biological processpeptide catabolic process
GO_0006508Biological processproteolysis
GO_0019885Biological processantigen processing and presentation of endogenous peptide antigen via MHC class I
GO_0005615Cellular componentextracellular space
GO_0005737Cellular componentcytoplasm
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0042277Molecular functionpeptide binding
GO_0004175Molecular functionendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0008237Molecular functionmetallopeptidase activity
GO_0070006Molecular functionmetalloaminopeptidase activity
GO_0004177Molecular functionaminopeptidase activity

IV. Literature review

[source]
Gene nameERAP2
Protein nameEndoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP)
Endoplasmic reticulum aminopeptidase 2
SynonymsLRAP
DescriptionFUNCTION: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. .

AccessionsENST00000510373.6 [Q6P179-1]
ENST00000513084.5 [Q6P179-2]
ENST00000437043.8 [Q6P179-1]
ENST00000510373.5
D6RF46
H0YAL8
ENST00000512869.1
D6RGW0
ENST00000510309.1 [Q6P179-4]
ENST00000508077.1
ENST00000379904.8 [Q6P179-3]
H0Y9X9
ENST00000507346.1
Q6P179