EPRS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032869Biological processcellular response to insulin stimulus
GO_0006433Biological processprolyl-tRNA aminoacylation
GO_0006424Biological processglutamyl-tRNA aminoacylation
GO_0006418Biological processtRNA aminoacylation for protein translation
GO_0017148Biological processnegative regulation of translation
GO_0140212Biological processregulation of long-chain fatty acid import into cell
GO_0071346Biological processcellular response to type II interferon
GO_0097452Cellular componentGAIT complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0017101Cellular componentaminoacyl-tRNA synthetase multienzyme complex
GO_0042803Molecular functionprotein homodimerization activity
GO_0051020Molecular functionGTPase binding
GO_0004827Molecular functionproline-tRNA ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0004818Molecular functionglutamate-tRNA ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0035613Molecular functionRNA stem-loop binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEPRS1
Protein nameglutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase)
Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]
Glutamyl-prolyl-tRNA synthetase 1
SynonymsQARS
PIG32
EPRS
PARS
QPRS
GLNS
EARS
DescriptionFUNCTION: Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) . Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts . Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan . .

AccessionsV9GYZ6
Q3KQZ8
ENST00000477030.2
ENST00000609181.5
V9GZ76
P07814
ENST00000366923.8