DYRK1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090312Biological processpositive regulation of protein deacetylation
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0033120Biological processpositive regulation of RNA splicing
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0031115Biological processnegative regulation of microtubule polymerization
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0006338Biological processchromatin remodeling
GO_0007623Biological processcircadian rhythm
GO_0034205Biological processamyloid-beta formation
GO_0038083Biological processpeptidyl-tyrosine autophosphorylation
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0090310Biological processnegative regulation of DNA methylation-dependent heterochromatin formation
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0006468Biological processprotein phosphorylation
GO_0036289Biological processpeptidyl-serine autophosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0007399Biological processnervous system development
GO_0043518Biological processnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO_0005856Cellular componentcytoskeleton
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0008353Molecular functionRNA polymerase II CTD heptapeptide repeat kinase activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0140857Molecular functionhistone H3T45 kinase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDYRK1A
Protein nameDual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Dual specificity tyrosine phosphorylation regulated kinase 1A (Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Protein kinase minibrain homolog)
Dual specificity tyrosine phosphorylation regulated kinase 1A
SynonymsDYRK1A_var1
DYRK
MNB
MNBH
DYRK1A_var2
DescriptionFUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities . Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 . Plays an important role in double-strand breaks (DSBs) repair following DNA damage . Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) . Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A . May play a role in a signaling pathway regulating nuclear functions of cell proliferation . Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). .

AccessionsA0A2R8Y6L5
ENST00000338785.8 [Q13627-5]
ENST00000644942.1 [Q13627-1]
A0A2R8Y6I6
ENST00000426672.6
ENST00000455097.6
ENST00000643854.1
A0A2R8YDF3
ENST00000645774.1
A0A2R8YEY4
E7EMI5
Q13627
ENST00000645424.1 [Q13627-4]
N0GVR9
A0A2R8Y443
ENST00000646548.1 [Q13627-2]
ENST00000398956.2 [Q13627-3]
ENST00000647504.1
ENST00000647188.2 [Q13627-2]
ENST00000646523.1
ENST00000643624.1 [Q13627-2]
ENST00000647425.1 [Q13627-2]
ENST00000398960.7 [Q13627-1]
ENST00000643551.1
ENST00000642309.1