DPYD | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	25 studies	46% ± 29%	Explore
endothelial cell	23 studies	43% ± 16%	Explore
classical monocyte	21 studies	32% ± 9%	Explore
monocyte	18 studies	39% ± 30%	Explore
oligodendrocyte	16 studies	76% ± 16%	Explore
fibroblast	15 studies	50% ± 20%	Explore
non-classical monocyte	13 studies	24% ± 10%	Explore
myeloid cell	12 studies	45% ± 26%	Explore
microglial cell	11 studies	47% ± 20%	Explore
glutamatergic neuron	11 studies	64% ± 24%	Explore
CD4-positive, alpha-beta T cell	11 studies	26% ± 14%	Explore
pericyte	10 studies	38% ± 16%	Explore
regulatory T cell	10 studies	27% ± 14%	Explore
dendritic cell	9 studies	44% ± 23%	Explore
adipocyte	9 studies	51% ± 17%	Explore
smooth muscle cell	9 studies	37% ± 13%	Explore
conventional dendritic cell	8 studies	25% ± 11%	Explore
GABAergic neuron	8 studies	41% ± 21%	Explore
oligodendrocyte precursor cell	8 studies	30% ± 13%	Explore
mucosal invariant T cell	8 studies	25% ± 14%	Explore
natural killer cell	8 studies	34% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	26% ± 15%	Explore
mast cell	8 studies	38% ± 15%	Explore
mesothelial cell	8 studies	51% ± 18%	Explore
endothelial cell of lymphatic vessel	8 studies	31% ± 17%	Explore
astrocyte	7 studies	40% ± 24%	Explore
CD8-positive, alpha-beta T cell	7 studies	28% ± 13%	Explore
T cell	7 studies	47% ± 21%	Explore
neuron	6 studies	45% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	28% ± 15%	Explore
type I pneumocyte	6 studies	48% ± 16%	Explore
type II pneumocyte	6 studies	70% ± 19%	Explore
hepatocyte	5 studies	66% ± 25%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	25% ± 13%	Explore
B cell	5 studies	29% ± 12%	Explore
cardiac muscle cell	5 studies	34% ± 7%	Explore
mature NK T cell	5 studies	28% ± 19%	Explore
alveolar macrophage	5 studies	61% ± 34%	Explore
basal cell	5 studies	43% ± 18%	Explore
club cell	5 studies	51% ± 22%	Explore
cholangiocyte	4 studies	56% ± 21%	Explore
epithelial cell	4 studies	31% ± 12%	Explore
capillary endothelial cell	4 studies	32% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	34% ± 18%	Explore
ciliated cell	4 studies	41% ± 13%	Explore
leukocyte	4 studies	60% ± 20%	Explore
interneuron	4 studies	34% ± 27%	Explore
gamma-delta T cell	4 studies	16% ± 1%	Explore
hepatic stellate cell	3 studies	50% ± 20%	Explore
endothelial cell of artery	3 studies	27% ± 9%	Explore
glial cell	3 studies	39% ± 17%	Explore
mononuclear phagocyte	3 studies	58% ± 27%	Explore
vein endothelial cell	3 studies	42% ± 14%	Explore
Mueller cell	3 studies	24% ± 7%	Explore
intermediate monocyte	3 studies	36% ± 15%	Explore
endothelial cell of vascular tree	3 studies	50% ± 12%	Explore
myofibroblast cell	3 studies	37% ± 10%	Explore
respiratory goblet cell	3 studies	58% ± 18%	Explore
lymphocyte	3 studies	56% ± 14%	Explore
muscle cell	3 studies	31% ± 12%	Explore
neutrophil	3 studies	46% ± 34%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	21% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	29% ± 17%	Explore
mural cell	3 studies	33% ± 13%	Explore
mucus secreting cell	3 studies	42% ± 7%	Explore
innate lymphoid cell	3 studies	33% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	51% ± 20%	Explore
peripheral blood	9 studies	21% ± 3%	Explore
lung	6 studies	51% ± 17%	Explore
heart	5 studies	41% ± 14%	Explore
liver	4 studies	37% ± 16%	Explore
kidney	4 studies	21% ± 4%	Explore
adipose	4 studies	51% ± 28%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	1944.45	651 / 653	97%	18.39	584 / 605
lung	100%	4014.01	578 / 578	94%	20.98	1087 / 1155
breast	100%	2818.73	459 / 459	93%	12.94	1036 / 1118
liver	100%	2504.50	225 / 226	92%	17.67	375 / 406
esophagus	100%	2196.00	1443 / 1445	86%	12.83	157 / 183
kidney	94%	1012.25	84 / 89	90%	14.08	815 / 901
uterus	100%	2385.40	170 / 170	84%	15.24	386 / 459
adrenal gland	98%	1982.37	253 / 258	86%	9.46	197 / 230
prostate	99%	1549.69	242 / 245	81%	7.51	409 / 502
pancreas	83%	673.74	271 / 328	93%	16.52	166 / 178
skin	96%	2397.51	1731 / 1809	68%	9.63	323 / 472
bladder	100%	2381.10	21 / 21	61%	9.08	305 / 504
ovary	100%	2597.17	180 / 180	60%	4.34	260 / 430
stomach	93%	1308.34	335 / 359	63%	7.68	180 / 286
intestine	100%	2080.06	962 / 966	52%	5.27	275 / 527
brain	36%	282.15	957 / 2642	68%	11.00	479 / 705
adipose	100%	3553.36	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2474.15	1335 / 1335	0%	0	0 / 0
spleen	100%	2910.41	241 / 241	0%	0	0 / 0
peripheral blood	97%	3589.15	897 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	17.16	41 / 45
heart	88%	956.89	758 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	79%	12.32	23 / 29
muscle	63%	402.19	508 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	11%	0.63	9 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006212	Biological process	uracil catabolic process
GO_0006145	Biological process	purine nucleobase catabolic process
GO_0006248	Biological process	CMP catabolic process
GO_0006249	Biological process	dCMP catabolic process
GO_0006214	Biological process	thymidine catabolic process
GO_0006208	Biological process	pyrimidine nucleobase catabolic process
GO_0046050	Biological process	UMP catabolic process
GO_0046079	Biological process	dUMP catabolic process
GO_0019483	Biological process	beta-alanine biosynthetic process
GO_0006210	Biological process	thymine catabolic process
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0042803	Molecular function	protein homodimerization activity
GO_0002058	Molecular function	uracil binding
GO_0050660	Molecular function	flavin adenine dinucleotide binding
GO_0017113	Molecular function	dihydropyrimidine dehydrogenase (NADP+) activity
GO_0050661	Molecular function	NADP binding
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding
GO_0051539	Molecular function	4 iron, 4 sulfur cluster binding

IV. Literature review

[source]

Gene name	DPYD
Protein name	Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)
Synonyms
Description	FUNCTION: Involved in pyrimidine base degradation . Catalyzes the reduction of uracil and thymine . Also involved the degradation of the chemotherapeutic drug 5-fluorouracil . .
Accessions	ENST00000370192.8 [Q12882-1] ENST00000306031.5 [Q12882-2] Q12882

DPYD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review