DNAJB11 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	22% ± 5%	Explore
plasma cell	16 studies	41% ± 14%	Explore
endothelial cell	16 studies	27% ± 8%	Explore
macrophage	13 studies	25% ± 10%	Explore
fibroblast	12 studies	25% ± 10%	Explore
plasmablast	11 studies	51% ± 24%	Explore
CD8-positive, alpha-beta T cell	11 studies	18% ± 2%	Explore
plasmacytoid dendritic cell	10 studies	30% ± 11%	Explore
conventional dendritic cell	9 studies	26% ± 11%	Explore
basal cell	8 studies	25% ± 9%	Explore
T cell	7 studies	21% ± 4%	Explore
classical monocyte	7 studies	24% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	20% ± 4%	Explore
monocyte	7 studies	20% ± 3%	Explore
epithelial cell	7 studies	39% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	19% ± 2%	Explore
connective tissue cell	6 studies	23% ± 5%	Explore
ciliated cell	6 studies	32% ± 11%	Explore
endothelial cell of vascular tree	6 studies	20% ± 5%	Explore
non-classical monocyte	5 studies	20% ± 4%	Explore
mature NK T cell	5 studies	17% ± 1%	Explore
IgG plasma cell	5 studies	27% ± 12%	Explore
pericyte	5 studies	21% ± 4%	Explore
endothelial cell of lymphatic vessel	5 studies	24% ± 8%	Explore
secretory cell	5 studies	20% ± 4%	Explore
gamma-delta T cell	5 studies	25% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 6%	Explore
hematopoietic precursor cell	4 studies	28% ± 9%	Explore
IgA plasma cell	4 studies	33% ± 12%	Explore
smooth muscle cell	4 studies	20% ± 4%	Explore
precursor B cell	4 studies	19% ± 3%	Explore
myeloid cell	4 studies	26% ± 10%	Explore
dendritic cell	4 studies	36% ± 15%	Explore
goblet cell	4 studies	26% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 4%	Explore
mast cell	4 studies	22% ± 5%	Explore
leukocyte	3 studies	26% ± 5%	Explore
naive B cell	3 studies	19% ± 2%	Explore
mononuclear phagocyte	3 studies	31% ± 13%	Explore
CD4-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
myofibroblast cell	3 studies	24% ± 3%	Explore
endothelial cell of artery	3 studies	18% ± 2%	Explore
vein endothelial cell	3 studies	16% ± 0%	Explore
abnormal cell	3 studies	22% ± 6%	Explore
regulatory T cell	3 studies	18% ± 2%	Explore
type I pneumocyte	3 studies	23% ± 6%	Explore
oligodendrocyte	3 studies	17% ± 1%	Explore
neuron	3 studies	29% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	24% ± 5%	Explore
peripheral blood	5 studies	21% ± 4%	Explore
brain	5 studies	22% ± 3%	Explore
kidney	4 studies	18% ± 3%	Explore
intestine	4 studies	24% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3194.30	578 / 578	100%	32.23	1155 / 1155
ovary	100%	1720.79	180 / 180	100%	24.21	430 / 430
pancreas	100%	2942.48	328 / 328	100%	21.83	178 / 178
stomach	100%	2318.27	359 / 359	100%	22.85	286 / 286
uterus	100%	2341.19	170 / 170	100%	37.40	459 / 459
esophagus	100%	1998.80	1444 / 1445	100%	25.47	183 / 183
breast	100%	2503.42	459 / 459	100%	21.76	1117 / 1118
intestine	100%	2421.23	966 / 966	100%	23.47	526 / 527
bladder	100%	2432.19	21 / 21	100%	25.02	503 / 504
liver	100%	4011.76	226 / 226	100%	23.85	405 / 406
thymus	100%	4519.54	653 / 653	100%	19.68	603 / 605
prostate	100%	2170.21	245 / 245	99%	16.39	499 / 502
skin	100%	2796.58	1808 / 1809	99%	24.43	469 / 472
brain	99%	1513.67	2619 / 2642	100%	14.59	705 / 705
kidney	100%	2491.22	89 / 89	99%	13.39	889 / 901
adrenal gland	100%	2214.79	258 / 258	94%	12.25	217 / 230
adipose	100%	2681.61	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.39	29 / 29
spleen	100%	3656.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	32.96	45 / 45
ureter	0%	0	0 / 0	100%	6.49	1 / 1
blood vessel	100%	2321.89	1332 / 1335	0%	0	0 / 0
heart	99%	2226.88	849 / 861	0%	0	0 / 0
muscle	98%	1093.89	783 / 803	0%	0	0 / 0
peripheral blood	95%	1929.53	879 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	93%	8.26	74 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006457	Biological process	protein folding
GO_0032781	Biological process	positive regulation of ATP-dependent activity
GO_0016556	Biological process	mRNA modification
GO_0050768	Biological process	negative regulation of neurogenesis
GO_0051604	Biological process	protein maturation
GO_0005615	Cellular component	extracellular space
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0101031	Cellular component	protein folding chaperone complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0034663	Cellular component	endoplasmic reticulum chaperone complex
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0051787	Molecular function	misfolded protein binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding
GO_0051082	Molecular function	unfolded protein binding

IV. Literature review

[source]

Gene name	DNAJB11
Protein name	DnaJ homolog subfamily B member 11 (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4)
Synonyms	PSEC0121 HDJ9 EDJ UNQ537/PRO1080 ERJ3
Description	FUNCTION: As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins . Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed . May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity . It is necessary for maturation and correct trafficking of PKD1 . .
Accessions	A0A7P0T9E8 ENST00000680338.1 ENST00000439351.5 ENST00000265028.8 Q9UBS4

DNAJB11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review