DHX15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0051607Biological processdefense response to virus
GO_0043279Biological processresponse to alkaloid
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042742Biological processdefense response to bacterium
GO_0009636Biological processresponse to toxic substance
GO_0140374Biological processantiviral innate immune response
GO_0005730Cellular componentnucleolus
GO_0005622Cellular componentintracellular anatomical structure
GO_0005681Cellular componentspliceosomal complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0071008Cellular componentU2-type post-mRNA release spliceosomal complex
GO_0005689Cellular componentU12-type spliceosomal complex
GO_0005634Cellular componentnucleus
GO_0004386Molecular functionhelicase activity
GO_0003724Molecular functionRNA helicase activity
GO_0008186Molecular functionATP-dependent activity, acting on RNA
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0003725Molecular functiondouble-stranded RNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameDHX15
Protein nameATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)
SynonymsDBP1
DDX15
DescriptionFUNCTION: RNA helicase involved in mRNA processing and antiviral innate immunity . Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA . In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns . Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome . Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) . Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses . The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu . Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity). .

AccessionsENST00000336812.5
O43143